BGC0000059: filipin biosynthetic gene cluster from Streptomyces avermitilis MA-4680 = NBRC 14893
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Location: 486,648 - 567,017 nt. (total: 80,370 nt).
This entry is originally from NCBI GenBank BA000030.3.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000059
Short description filipin biosynthetic gene cluster from Streptomyces avermitilis MA-4680 = NBRC 14893
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
BA000030.3
486648 - 567017
via
Compounds
  • filipin
Species Streptomyces avermitilis MA-4680 = NBRC 14893 [taxonomy]
References
Chemical products information
filipin Evidence:
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C35H58O11
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SAV_407
  • BAC68117.1
  • pteH
 486648 - 487415 (-) thioesterase
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    • SAV_408
    • BAC68118.1
    • pteG
    		 487512 - 489155 (-) putative cholesterol oxidase
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      • SAV_409
      • BAC68119.1
      • pteF
      		 489621 - 490319 (-) putative LuxR-family transcriptional regulator
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        • SAV_410
        • BAC68120.2
        • pteR
        		 490599 - 494192 (+) DnrI/RedD/AfsR-family transcriptional regulator
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          • SAV_411
          • BAC68121.1
          • pteE
          		 494248 - 494442 (-) ferredoxin
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            • SAV_412
            • BAC68122.2
            • pteD
            		 494487 - 495701 (-) cytochrome P450 hydroxylase
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              • SAV_413
              • BAC68123.1
              • pteC
              		 496283 - 497482 (-) cytochrome P450 hydroxylase
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                • SAV_414
                • BAC68124.1
                • pteB
                		 497529 - 498785 (-) putative dehydrogenase
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                  • SAV_415
                  • BAC68125.1
                  • pteA5
                  		 498846 - 508904 (-) modular polyketide synthase
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                    • SAV_416
                    • BAC68126.1
                    • pteA4
                    		 508951 - 527388 (-) modular polyketide synthase
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                      • SAV_417
                      • BAC68127.1
                      • pteA3
                      		 527468 - 532975 (-) modular polyketide synthase
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                        • SAV_418
                        • BAC68128.1
                        • pteA2
                        		 533011 - 543705 (-) modular polyketide synthase
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                          • SAV_419
                          • BAC68129.1
                          • pteA1
                          		 543777 - 567017 (-) modular polyketide synthase
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                            Biosynthesis information
                            Annotation changelog

                            Entry version: 4

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-10-07
                            Update chemical activity to schema version 2.11
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Updated bioactivity data
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Migrated from v1.4
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2015-06-12
                            Submitted
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            Detailed domain annotation
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