BGC0000059 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000059 (Streptomyces avermitilis MA-4680 = NBRC 14893)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	80,370	pentamycin	Polyketide	86%

BGC0000059 - Region 1 - T1PKS

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Location: 1 - 80,370 nt. (total: 80,370 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 80,371
Label		BGC0000059

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000059.1	0.85	Polyketide	filipin	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0002032.1	0.54	Polyketide	pentamycin	Streptomyces sp. S816
BGC0000041.1	0.35	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000043.1	0.32	Polyketide	curacin A	Moorea producens 19L
BGC0000113.1	0.32	Polyketide	niddamycin	Streptomyces caelestis
BGC0000018.1	0.32	Polyketide	angolamycin	Streptomyces eurythermus
BGC0001164.1	0.31	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000067.1	0.31	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001854.1	0.30	Polyketide	tricholignan A	Trichoderma harzianum
BGC0001276.1	0.29	Polyketide	6-methylsalicyclic acid	Aspergillus terreus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000059.1	0.95	Polyketide	filipin	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0002032.1	0.81	Polyketide	pentamycin	Streptomyces sp. S816
BGC0000041.1	0.68	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000043.1	0.65	Polyketide	curacin A	Moorea producens 19L
BGC0000113.1	0.65	Polyketide	niddamycin	Streptomyces caelestis
BGC0000018.1	0.65	Polyketide	angolamycin	Streptomyces eurythermus
BGC0001164.1	0.65	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000067.1	0.64	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001854.1	0.64	Polyketide	tricholignan A	Trichoderma harzianum
BGC0001276.1	0.63	Polyketide	6-methylsalicyclic acid	Aspergillus terreus

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 80370:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ohmal - ccmal - ccmal - ccmal) + (ohmal - ohmal - ohmal - ohmal) + (ccmal) + (ccmal - pk) + (ohmal - pk)
Non-colinear ordering:: SAV_419 + SAV_416 + SAV_417 + SAV_418 + SAV_415

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

SAV_415

PKS_AT (563..838): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.4
inactive: 103.9
Methoxymalonyl-CoA: 71.0
Methylmalonyl-CoA: 64.7
Propionyl-CoA: 38.4
Ethylmalonyl-CoA: 35.4
CHC-CoA: 26.0
Benzoyl-CoA: 23.9
Acetyl-CoA: 22.9
Isobutyryl-CoA: 20.2
trans-1,2-CPDA: 17.7
2-Methylbutyryl-CoA: 15.2
fatty_acid: 10.4
3-Methylbutyryl-CoA: 0.0

PKS_AT (2068..2365): pk

ATSignature: Methoxymalonyl-CoA

Top 3 matches:: Methoxymalonyl-CoA: 79.2%; Ethylmalonyl-CoA: 75.0%; Methylmalonyl-CoA: 75.0%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 196.2
Methylmalonyl-CoA: 186.9
Methoxymalonyl-CoA: 174.1
2-Methylbutyryl-CoA: 135.1
trans-1,2-CPDA: 131.2
Propionyl-CoA: 114.2
CHC-CoA: 98.8
Isobutyryl-CoA: 96.6
Malonyl-CoA: 92.5
Benzoyl-CoA: 72.9
Acetyl-CoA: 53.7
fatty_acid: 51.5
3-Methylbutyryl-CoA: 36.3
inactive: 29.4

SAV_416

PKS_AT (559..839): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.9
inactive: 114.8
Methylmalonyl-CoA: 62.2
Methoxymalonyl-CoA: 61.7
Propionyl-CoA: 40.3
2-Methylbutyryl-CoA: 30.0
Ethylmalonyl-CoA: 29.0
Isobutyryl-CoA: 28.7
Benzoyl-CoA: 27.9
Acetyl-CoA: 21.6
CHC-CoA: 20.7
trans-1,2-CPDA: 20.1
fatty_acid: 11.6
3-Methylbutyryl-CoA: 0.0

PKS_AT (2072..2347): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 214.5
inactive: 112.0
Methoxymalonyl-CoA: 56.5
Methylmalonyl-CoA: 56.4
Propionyl-CoA: 33.6
Ethylmalonyl-CoA: 23.7
Isobutyryl-CoA: 23.1
Acetyl-CoA: 21.9
Benzoyl-CoA: 21.6
2-Methylbutyryl-CoA: 21.1
CHC-CoA: 18.6
fatty_acid: 14.7
trans-1,2-CPDA: 8.8
3-Methylbutyryl-CoA: 0.0

PKS_AT (3576..3859): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 200.1
inactive: 106.0
Methoxymalonyl-CoA: 60.0
Methylmalonyl-CoA: 52.6
Propionyl-CoA: 26.3
Isobutyryl-CoA: 18.4
Ethylmalonyl-CoA: 17.0
Benzoyl-CoA: 15.9
Acetyl-CoA: 12.8
2-Methylbutyryl-CoA: 10.6
trans-1,2-CPDA: 10.5
CHC-CoA: 4.5
3-Methylbutyryl-CoA: 4.1
fatty_acid: 0.0

PKS_AT (5103..5378): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 215.1
inactive: 111.0
Methoxymalonyl-CoA: 60.6
Methylmalonyl-CoA: 58.3
Propionyl-CoA: 31.9
Acetyl-CoA: 30.1
Ethylmalonyl-CoA: 26.6
Benzoyl-CoA: 24.5
Isobutyryl-CoA: 23.3
2-Methylbutyryl-CoA: 19.1
CHC-CoA: 16.0
fatty_acid: 10.8
trans-1,2-CPDA: 8.8
3-Methylbutyryl-CoA: 0.0

SAV_417

PKS_AT (575..854): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 212.1
inactive: 118.8
Methoxymalonyl-CoA: 62.7
Methylmalonyl-CoA: 57.5
Propionyl-CoA: 38.9
Ethylmalonyl-CoA: 29.3
2-Methylbutyryl-CoA: 28.6
Isobutyryl-CoA: 23.1
Benzoyl-CoA: 21.7
Acetyl-CoA: 18.7
trans-1,2-CPDA: 17.3
CHC-CoA: 13.8
fatty_acid: 9.5
3-Methylbutyryl-CoA: 0.0

SAV_418

PKS_AT (585..862): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.2
inactive: 105.4
Methoxymalonyl-CoA: 62.6
Methylmalonyl-CoA: 54.6
Propionyl-CoA: 40.1
Acetyl-CoA: 27.6
Benzoyl-CoA: 25.4
2-Methylbutyryl-CoA: 23.6
Ethylmalonyl-CoA: 20.3
trans-1,2-CPDA: 16.9
Isobutyryl-CoA: 12.9
CHC-CoA: 12.2
fatty_acid: 11.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (2310..2605): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 87.5%; Malonyl-CoA: 83.3%; Methoxymalonyl-CoA: 83.3%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 197.5
Methylmalonyl-CoA: 188.3
Methoxymalonyl-CoA: 158.6
2-Methylbutyryl-CoA: 137.6
trans-1,2-CPDA: 129.9
Propionyl-CoA: 102.8
CHC-CoA: 84.3
Malonyl-CoA: 80.5
Isobutyryl-CoA: 79.0
Benzoyl-CoA: 58.5
Acetyl-CoA: 45.8
3-Methylbutyryl-CoA: 25.6
fatty_acid: 16.4
inactive: 15.2

SAV_419

PKS_AT (552..851): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 222.8
inactive: 121.1
Methoxymalonyl-CoA: 65.8
Methylmalonyl-CoA: 54.5
Isobutyryl-CoA: 32.5
Propionyl-CoA: 32.4
Acetyl-CoA: 20.2
Ethylmalonyl-CoA: 15.4
Benzoyl-CoA: 14.6
2-Methylbutyryl-CoA: 10.2
CHC-CoA: 9.9
trans-1,2-CPDA: 9.8
fatty_acid: 9.7
3-Methylbutyryl-CoA: 0.0

PKS_AT (1578..1858): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 211.6
inactive: 114.8
Methoxymalonyl-CoA: 61.0
Methylmalonyl-CoA: 57.5
Propionyl-CoA: 32.6
Acetyl-CoA: 30.6
Ethylmalonyl-CoA: 28.7
Isobutyryl-CoA: 24.4
Benzoyl-CoA: 22.2
CHC-CoA: 20.6
2-Methylbutyryl-CoA: 19.9
trans-1,2-CPDA: 8.7
fatty_acid: 7.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (3081..3361): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.5
inactive: 105.4
Methoxymalonyl-CoA: 49.0
Methylmalonyl-CoA: 45.1
Propionyl-CoA: 26.9
Benzoyl-CoA: 21.0
2-Methylbutyryl-CoA: 17.2
Ethylmalonyl-CoA: 15.7
Isobutyryl-CoA: 15.3
CHC-CoA: 13.6
Acetyl-CoA: 12.3
trans-1,2-CPDA: 10.9
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (4815..5095): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 203.2
inactive: 114.4
Methoxymalonyl-CoA: 57.1
Methylmalonyl-CoA: 51.9
Ethylmalonyl-CoA: 27.9
Propionyl-CoA: 26.0
Benzoyl-CoA: 22.6
Acetyl-CoA: 22.4
Isobutyryl-CoA: 21.4
2-Methylbutyryl-CoA: 18.9
CHC-CoA: 16.7
trans-1,2-CPDA: 13.8
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (6501..6771): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.6
inactive: 107.5
Methoxymalonyl-CoA: 57.0
Methylmalonyl-CoA: 53.9
Acetyl-CoA: 36.7
Propionyl-CoA: 30.5
Ethylmalonyl-CoA: 26.9
Isobutyryl-CoA: 18.6
2-Methylbutyryl-CoA: 17.8
Benzoyl-CoA: 17.4
CHC-CoA: 13.9
trans-1,2-CPDA: 12.9
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0