BGC0000070: griseofulvin biosynthetic gene cluster from Penicillium aethiopicum
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Location: 1 - 55,000 nt. (total: 55,000 nt).
This entry is originally from NCBI GenBank GU574478.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000070
Short description griseofulvin biosynthetic gene cluster from Penicillium aethiopicum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Iterative type I)
Loci
GU574478.1
via Knock-out studies, Enzymatic assays, Heterologous expression, Gene expression correlated with compound production
Compounds
  • griseofulvin
  • epidechlorogriseofulvin
Species Penicillium aethiopicum [taxonomy]
References
Chemical products information
griseofulvin [synonyms: grisovin, fulvicin, spirofulvin, griseofulvinum, grisactin] Evidence: Mass spectrometry [1], [2]
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C17H17Cl1O6
Chemical database entries
PubCHEM
NPAtlas
epidechlorogriseofulvin Evidence: Mass spectrometry [1], [2]
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C17H18O6
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADI24961.1
 326 - 1571 (+) unknown
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    • ADI24962.1
    		 1937 - 3246 (-) unknown
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      • ADI24963.1
      		 3547 - 4311 (-) unknown
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        • ADI24964.1
        		 6360 - 8546 (+) unknown
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          • ADI24952.1
          		 9820 - 11067 (-) GsfR2
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            • ADI24951.1
            		 11558 - 12585 (+) ketoreductase
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              • ADI24950.1
              		 13037 - 15154 (-) GsfR1
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                • ADI24949.1
                		 16116 - 18146 (+) GsfJ
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                  • ADI24948.1
                  		 18939 - 20914 (+) halogenase
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                    • ADI24953.1
                    		 21525 - 27196 (+) NR-PKS (SAT-KS-AT-PT-ACP)
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                      • ADI24954.1
                      		 27654 - 29095 (-) (3-OH) O-methyltransferase
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                        • ADI24955.1
                        		 29983 - 31173 (-) (9-OH), O-methyltransferase
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                          • ADI24956.1
                          		 31596 - 32896 (+) (5-OH), O-methyltransferase
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                            • ADI24957.1
                            		 33259 - 34392 (-) short-chain dehydrogenase/reductase
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                              • ADI24958.2
                              		 35027 - 36729 (+) cytochrome P450
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                                • ADI24959.1
                                		 36846 - 37878 (-) GsfG
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                                  • ADI24960.1
                                  		 40829 - 41717 (+) GsfH
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                                    • ADI24965.1
                                    		 42603 - 44954 (-) unknown
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                                      • ADI24966.1
                                      		 48793 - 49599 (-) unknown
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                                        • ADI24967.1
                                        		 50369 - 51714 (+) unknown
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                                          • ADI24968.1
                                          		 52308 - 54575 (+) unknown
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                                            Biosynthesis information
                                            Annotation changelog

                                            Entry version: next

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2024-06-05
                                            MIBiG v4 annotathon
                                            • (ID: D44UGPXERIZAXNCG2VXZP5I3)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 4

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-10-07
                                            Update chemical activity to schema version 2.11
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 3

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-09-15
                                            Corrected gene identifiers
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 2

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2019-10-16
                                            Migrated from v1.4
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2019-10-16
                                            Updated compound(s) information (NPAtlas curation)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 1

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2015-06-12
                                            Submitted
                                            • (ID: BMUFDHMMOLZWQLUNJMQED2GP)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            Detailed domain annotation
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