BGC0000074: herbimycin A biosynthetic gene cluster from Streptomyces hygroscopicus
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 86,941 nt. (total: 86,941 nt).
This entry is originally from NCBI GenBank AY947889.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000074
Short description herbimycin A biosynthetic gene cluster from Streptomyces hygroscopicus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
AY947889.1
via
Compounds
  • herbimycin A
Species Streptomyces hygroscopicus [taxonomy]
References
Chemical products information
herbimycin A Evidence:
Copy SMILES
C30H42N2O9
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAY28209.1
 71 - 2359 (-) unknown
    copy AA seq
    copy Nt seq
    • AAY28210.1
    		 2359 - 2775 (-) unknown
      copy AA seq
      copy Nt seq
      • AAY28211.1
      		 2762 - 3745 (-) unknown
        copy AA seq
        copy Nt seq
        • AAY28212.1
        		 3757 - 5013 (-) unknown
          copy AA seq
          copy Nt seq
          • AAY28213.1
          		 5026 - 6852 (-) unknown
            copy AA seq
            copy Nt seq
            • AAY28214.1
            		 6887 - 8317 (-) putative transmembrane efflux protein
              copy AA seq
              copy Nt seq
              • AAY28215.1
              		 8437 - 9207 (-) unknown
                copy AA seq
                copy Nt seq
                • AAY28216.1
                		 9204 - 10286 (-) FtrD
                  copy AA seq
                  copy Nt seq
                  • AAY28217.1
                  		 10286 - 11362 (-) lipoprotein
                    copy AA seq
                    copy Nt seq
                    • AAY28218.1
                    		 18360 - 19043 (-) unknown
                      copy AA seq
                      copy Nt seq
                      • AAY28219.1
                      		 21063 - 21965 (-) putative secreted protein
                        copy AA seq
                        copy Nt seq
                        • AAY28220.1
                        		 22155 - 22946 (-) putative hydrolase
                          copy AA seq
                          copy Nt seq
                          • AAY28221.1
                          		 23100 - 23984 (+) putative transcriptional regulator
                            copy AA seq
                            copy Nt seq
                            • AAY28222.1
                            		 24036 - 24797 (-) putative transcriptional regulator
                              copy AA seq
                              copy Nt seq
                              • AAY28223.1
                              • hbmL
                              		 24781 - 26277 (+) HbmL
                                copy AA seq
                                copy Nt seq
                                • AAY28224.1
                                • hbmX
                                		 26325 - 26795 (-) HbmX
                                  copy AA seq
                                  copy Nt seq
                                  • AAY28225.1
                                  • hbmAI
                                  		 27677 - 48139 (+) HbmAI
                                    copy AA seq
                                    copy Nt seq
                                    • AAY28226.1
                                    • hbmAII
                                    		 48197 - 58492 (+) HbmAII
                                      copy AA seq
                                      copy Nt seq
                                      • AAY28227.1
                                      • hbmAIII
                                      		 58519 - 70125 (+) HbmAIII
                                        copy AA seq
                                        copy Nt seq
                                        • AAY28228.1
                                        • hbmN
                                        		 70662 - 72719 (-) HbmN
                                          copy AA seq
                                          copy Nt seq
                                          • AAY28229.1
                                          • hbmH
                                          		 72781 - 73893 (-) HbmH
                                            copy AA seq
                                            copy Nt seq
                                            • AAY28230.1
                                            • hbmI
                                            		 73890 - 75002 (-) HbmI
                                              copy AA seq
                                              copy Nt seq
                                              • AAY28231.1
                                              • hbmJ
                                              		 74999 - 75274 (-) HbmJ
                                                copy AA seq
                                                copy Nt seq
                                                • AAY28232.1
                                                • hbmK
                                                		 75271 - 76137 (-) HbmK
                                                  copy AA seq
                                                  copy Nt seq
                                                  • AAY28233.1
                                                  • hbmG
                                                  		 76381 - 77037 (+) HbmG
                                                    copy AA seq
                                                    copy Nt seq
                                                    • AAY28234.1
                                                    • hbmRII
                                                    		 77137 - 79917 (-) HbmRII
                                                      copy AA seq
                                                      copy Nt seq
                                                      • AAY28235.1
                                                      • hbmO
                                                      		 80193 - 81257 (-) HbmO
                                                        copy AA seq
                                                        copy Nt seq
                                                        • AAY28236.1
                                                        • hbmFdx
                                                        		 81334 - 81528 (-) HbmFdx
                                                          copy AA seq
                                                          copy Nt seq
                                                          • AAY28237.1
                                                          • hbmP
                                                          		 81571 - 82764 (-) HbmP
                                                            copy AA seq
                                                            copy Nt seq
                                                            • AAY28238.1
                                                            • hbmRI
                                                            		 82921 - 85764 (-) HbmRI
                                                              copy AA seq
                                                              copy Nt seq
                                                              Biosynthesis information
                                                              Annotation changelog

                                                              Entry version: 4

                                                              Date
                                                              Changes
                                                              Submitters
                                                              Reviewers
                                                              2022-10-07
                                                              Update chemical activity to schema version 2.11
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                              Entry version: 3

                                                              Date
                                                              Changes
                                                              Submitters
                                                              Reviewers
                                                              2022-09-15
                                                              Updated bioactivity data
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                              Entry version: 2

                                                              Date
                                                              Changes
                                                              Submitters
                                                              Reviewers
                                                              2019-10-16
                                                              Migrated from v1.4
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              2019-10-16
                                                              Updated compound(s) information (NPAtlas curation)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                              Entry version: 1

                                                              Date
                                                              Changes
                                                              Submitters
                                                              Reviewers
                                                              2015-06-12
                                                              Submitted
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              Detailed domain annotation
                                                              Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                              A domain glossary is available here, and an explanation of the visualisation is available here.
                                                              Selected features only
                                                              Show module domains
                                                              Similar known gene clusters from MIBiG 4.0
                                                              Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                              Click on reference genes to show details of similarities to genes within the current region.
                                                              Click on an accession to open that entry in the MiBIG database.