BGC0000077 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000077 (Hypomyces subiculosus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	42,765	High	hypothemycin	PKS

BGC0000077 - Region 1 - T1PKS

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Location: 1 - 42,765 nt. (total: 42,765 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 42,766
Label		BGC0000077

Tailoring functions

Oxidoreductases: oxidase oxygenase

Hpm1: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

hpm9: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

Transferases: methyltransferase sulfotransferase

hpm2: glutathione S-transferase

smcogs: SMCOG1193: glutathione S-transferase

hpm5: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Ligases: synthase

hpm3: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

hpm8: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000077.3	1.00	PKS	hypothemycin	Hypomyces subiculosus
BGC0000076.3	1.00	PKS	hypothemycin	Hypomyces subiculosus
BGC0002175.3	0.76	PKS	YWA1	Aspergillus oryzae RIB40
BGC0002154.2	0.76	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001258.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000107.3	0.76	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001257.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001284.4	0.76	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000077.3	1.00	PKS	hypothemycin	Hypomyces subiculosus
BGC0000076.3	1.00	PKS	hypothemycin	Hypomyces subiculosus
BGC0002175.3	0.76	PKS	YWA1	Aspergillus oryzae RIB40
BGC0002154.2	0.76	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001258.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000107.3	0.76	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001257.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001284.4	0.76	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 42765:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (pk)
Non-colinear ordering:: hpm3 + hpm8

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

hpm3: mal

PKS_AT (888..1183): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 58.3%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 102.0
inactive: 67.1
Methoxymalonyl-CoA: 64.0
Methylmalonyl-CoA: 52.3
Isobutyryl-CoA: 37.6
Benzoyl-CoA: 25.8
Ethylmalonyl-CoA: 25.4
Propionyl-CoA: 24.5
2-Methylbutyryl-CoA: 23.1
Acetyl-CoA: 22.1
fatty_acid: 18.2
3-Methylbutyryl-CoA: 17.0
CHC-CoA: 16.5
trans-1,2-CPDA: 14.8

hpm8: pk

PKS_AT (551..862): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; Methylmalonyl-CoA: 70.8%; 2-Methylbutyryl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 84.3
Methoxymalonyl-CoA: 77.0
Malonyl-CoA: 59.7
Ethylmalonyl-CoA: 53.1
Isobutyryl-CoA: 45.7
Benzoyl-CoA: 30.5
Propionyl-CoA: 29.8
2-Methylbutyryl-CoA: 19.8
trans-1,2-CPDA: 19.2
fatty_acid: 18.2
CHC-CoA: 15.3
inactive: 11.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor