BGC0000084: laidlomycin biosynthetic gene cluster from Streptomyces sp. CS684
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Location: 1 - 102,840 nt. (total: 102,840 nt).
This entry is originally from NCBI GenBank JQ793783.1.

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core biosynthetic genes
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resistance
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000084
Short description laidlomycin biosynthetic gene cluster from Streptomyces sp. CS684
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
JQ793783.1
via
Compounds
  • laidlomycin
Species Streptomyces sp. CS684 [taxonomy]
References
Chemical products information
laidlomycin Evidence:
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C37H62O12
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFL48545.1
 114 - 698 (+) hypothetical protein
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    • AFL48544.1
    		 1095 - 2804 (-) putative cytochrome c oxidase
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      • AFL48547.1
      		 3136 - 5487 (-) putative histidine kinase sensor
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        • AFL48546.1
        		 5867 - 8620 (+) putative magnesium/manganese-dependent protein phosphatase
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          • AFL48521.1
          • ladA
          		 9021 - 11429 (-) beta-ketosynthase
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            • AFL48522.1
            • ladBI
            		 11522 - 12424 (-) Epoxide hydrolase
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              • AFL48523.1
              • ladT
              		 12705 - 14240 (+) laidlomycin efflux protein
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                • AFL48548.1
                • ladRI
                		 14254 - 14829 (+) Transcription regulator (TetR family)
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                  • AFL48524.1
                  • ladD
                  		 15060 - 15848 (-) Thioesterase
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                    • AFL48525.1
                    • ladSI
                    		 16118 - 23410 (+) laidlomycin polyketide synthase (loading module and module 1)
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                      • AFL48526.1
                      • ladSII
                      		 23417 - 29932 (+) laidlomycin polyketide synthase (module 2)
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                        • AFL48527.1
                        • ladSIII
                        		 29985 - 41879 (+) laidlomycin polyketide synthase (module 3 and module 4)
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                          • AFL48529.1
                          • ladSIV
                          		 41965 - 53637 (+) laidlomycin polyketide synthase (module 5 and module 6)
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                            • AFL48528.1
                            • ladSV
                            		 53687 - 65374 (+) laidlomycin polyketide synthase (module 7 and module 8)
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                              • AFL48520.1
                              • ladSVI
                              		 65392 - 70269 (+) laidlomycin polyketide synthase (module 9)
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                                • AFL48550.1
                                • ladBII
                                		 70432 - 71877 (-) epoxide hydrolase
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                                  • AFL48530.1
                                  • ladCI
                                  		 71874 - 72311 (-) epoxidase
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                                    • AFL48531.1
                                    • ladCII
                                    		 72336 - 72770 (-) Epoxidase
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                                      • AFL48532.1
                                      • ladSVIII
                                      		 72767 - 83737 (-) laidlomycin polyketide synthase (module 11 and module 12)
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                                        • AFL48533.1
                                        • ladSVII
                                        		 83802 - 88688 (-) laidlomycin polyketide synthase (module 10)
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                                          • AFL48549.1
                                          • ladE
                                          		 88923 - 90233 (+) cytochrome P450 hydroxylase
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                                            • AFL48534.1
                                            • ladRII
                                            		 90315 - 91100 (-) transcription regulator (SARP family)
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                                              • AFL48535.1
                                              • ladF
                                              		 91872 - 92300 (+) hypothetical protein
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                                                • AFL48536.1
                                                • ladG
                                                		 92698 - 93945 (-) putative acyl transferase
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                                                  • AFL48537.1
                                                  		 94049 - 94714 (-) putative membrane protein
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                                                    • AFL48538.1
                                                    		 95176 - 96501 (+) putative major facilitator superfamily transporter
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                                                      • AFL48539.1
                                                      		 96627 - 98033 (+) putative succinic semialdehyde dehydrogenase
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                                                        • AFL48540.1
                                                        		 98254 - 99468 (+) hypothetical protein
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                                                          • AFL48541.1
                                                          		 99495 - 99962 (-) hypothetical protein
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                                                            • AFL48542.1
                                                            		 100172 - 101158 (-) putative dihydroxyacetone kinase
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                                                              • AFL48543.1
                                                              		 101360 - 102391 (+) putative peptide transporter (ATP-binding subunit)
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                                                                • AFL48551.1
                                                                		 102589 - >102840 (+) peptide transporter (peptide-binding subunit)
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                                                                  Biosynthesis information
                                                                  Annotation changelog

                                                                  Entry version: 4

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2022-10-07
                                                                  Update chemical activity to schema version 2.11
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 3

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2022-09-15
                                                                  Updated bioactivity data
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 2

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2019-10-16
                                                                  Migrated from v1.4
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  2019-10-16
                                                                  Updated compound(s) information (NPAtlas curation)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 1

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2015-06-12
                                                                  Submitted
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  Detailed domain annotation
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