BGC0000084 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000084 (Streptomyces sp. CS684)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	102,840	monensin	Polyketide	55%

BGC0000084 - Region 1 - T1PKS

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Location: 1 - 102,840 nt. (total: 102,840 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 102,841
Label		BGC0000084

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000084.1	0.84	Polyketide	laidlomycin	Streptomyces sp. CS684
BGC0001670.1	0.40	Polyketide	monensin	Streptomyces cinnamonensis
BGC0001164.1	0.33	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000068.1	0.33	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0000041.1	0.32	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000120.1	0.31	Polyketide	patulin	Penicillium expansum
BGC0001913.1	0.31	Polyketide	phomoidride	fungal sp. ATCC 74256
BGC0001340.1	0.31	Polyketide	byssochlamic acid	Byssochlamys fulva
BGC0000122.1	0.31	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0001273.1	0.31	Polyketide	asperlactone	Aspergillus ochraceus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000084.1	0.95	Polyketide	laidlomycin	Streptomyces sp. CS684
BGC0001670.1	0.72	Polyketide	monensin	Streptomyces cinnamonensis
BGC0001164.1	0.66	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000068.1	0.66	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0000041.1	0.65	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000120.1	0.65	Polyketide	patulin	Penicillium expansum
BGC0001913.1	0.65	Polyketide	phomoidride	fungal sp. ATCC 74256
BGC0001340.1	0.64	Polyketide	byssochlamic acid	Byssochlamys fulva
BGC0000122.1	0.64	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0001273.1	0.64	Polyketide	asperlactone	Aspergillus ochraceus

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 102840:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-mal) + (Me-redmal) + (ccmal - Me-redmal) + (Me-ccmal - redmal) + (Me-ccmal - redmal) + (ohmal) + (Me-ohmal - Me-ccmal) + (Me-ohmal)
Non-colinear ordering:: ladSI + ladSII + ladSIII + ladSIV + ladSV + ladSVI + ladSVIII + ladSVII

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ladSI

PKS_AT (541..845): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 193.2
inactive: 96.6
Methoxymalonyl-CoA: 68.2
Methylmalonyl-CoA: 50.9
Isobutyryl-CoA: 36.6
Propionyl-CoA: 29.6
Benzoyl-CoA: 23.8
Ethylmalonyl-CoA: 17.2
Acetyl-CoA: 13.9
CHC-CoA: 10.0
2-Methylbutyryl-CoA: 9.8
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (1551..1845): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 207.2
Ethylmalonyl-CoA: 197.5
Methoxymalonyl-CoA: 170.8
2-Methylbutyryl-CoA: 143.7
trans-1,2-CPDA: 125.2
Propionyl-CoA: 120.2
CHC-CoA: 117.4
Malonyl-CoA: 108.1
Isobutyryl-CoA: 75.9
Benzoyl-CoA: 52.1
fatty_acid: 47.5
Acetyl-CoA: 45.9
3-Methylbutyryl-CoA: 34.1
inactive: 25.3

ladSII

PKS_AT (564..858): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 203.4
Ethylmalonyl-CoA: 196.8
Methoxymalonyl-CoA: 165.8
2-Methylbutyryl-CoA: 136.4
trans-1,2-CPDA: 123.4
Propionyl-CoA: 122.2
CHC-CoA: 114.5
Malonyl-CoA: 108.3
Isobutyryl-CoA: 68.3
Acetyl-CoA: 57.8
fatty_acid: 56.0
Benzoyl-CoA: 43.8
3-Methylbutyryl-CoA: 38.5
inactive: 29.6

ladSIII

PKS_AT (586..887): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 220.2
inactive: 108.5
Methoxymalonyl-CoA: 54.5
Methylmalonyl-CoA: 52.1
Isobutyryl-CoA: 30.6
Propionyl-CoA: 26.7
Benzoyl-CoA: 20.5
2-Methylbutyryl-CoA: 20.1
Acetyl-CoA: 19.2
Ethylmalonyl-CoA: 18.7
CHC-CoA: 8.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2373..2667): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 202.1
Ethylmalonyl-CoA: 198.6
Methoxymalonyl-CoA: 164.4
2-Methylbutyryl-CoA: 135.3
Propionyl-CoA: 120.0
trans-1,2-CPDA: 118.1
CHC-CoA: 104.6
Malonyl-CoA: 103.9
Isobutyryl-CoA: 72.2
Acetyl-CoA: 58.8
fatty_acid: 52.0
Benzoyl-CoA: 44.5
3-Methylbutyryl-CoA: 32.0
inactive: 23.2

ladSIV

PKS_AT (568..862): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 201.5
Ethylmalonyl-CoA: 196.4
Methoxymalonyl-CoA: 163.4
2-Methylbutyryl-CoA: 132.5
trans-1,2-CPDA: 116.5
Propionyl-CoA: 116.4
Malonyl-CoA: 105.4
CHC-CoA: 104.8
Isobutyryl-CoA: 71.6
Acetyl-CoA: 59.0
fatty_acid: 52.4
Benzoyl-CoA: 47.9
3-Methylbutyryl-CoA: 33.1
inactive: 26.3

PKS_AT (2301..2584): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.5
inactive: 101.4
Methoxymalonyl-CoA: 75.4
Methylmalonyl-CoA: 70.9
Propionyl-CoA: 46.7
fatty_acid: 45.4
Isobutyryl-CoA: 44.4
Ethylmalonyl-CoA: 34.6
Acetyl-CoA: 34.5
trans-1,2-CPDA: 27.3
Benzoyl-CoA: 25.2
CHC-CoA: 19.5
2-Methylbutyryl-CoA: 19.2
3-Methylbutyryl-CoA: 10.7

ladSV

PKS_AT (563..857): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 201.8
Ethylmalonyl-CoA: 198.7
Methoxymalonyl-CoA: 165.3
2-Methylbutyryl-CoA: 136.5
Propionyl-CoA: 119.6
trans-1,2-CPDA: 115.7
CHC-CoA: 105.4
Malonyl-CoA: 103.5
Isobutyryl-CoA: 73.0
Acetyl-CoA: 59.4
fatty_acid: 53.5
Benzoyl-CoA: 45.7
3-Methylbutyryl-CoA: 33.4
inactive: 23.9

PKS_AT (2318..2601): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.0
inactive: 101.2
Methoxymalonyl-CoA: 73.5
Methylmalonyl-CoA: 68.3
Propionyl-CoA: 48.0
fatty_acid: 43.7
Isobutyryl-CoA: 36.1
Acetyl-CoA: 35.6
Ethylmalonyl-CoA: 32.3
trans-1,2-CPDA: 25.6
Benzoyl-CoA: 25.0
CHC-CoA: 21.2
2-Methylbutyryl-CoA: 20.7
3-Methylbutyryl-CoA: 10.4

ladSVI

PKS_AT (569..863): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.6
inactive: 100.7
Methoxymalonyl-CoA: 74.3
Methylmalonyl-CoA: 71.0
Isobutyryl-CoA: 47.8
Propionyl-CoA: 46.3
fatty_acid: 44.2
Ethylmalonyl-CoA: 33.9
Acetyl-CoA: 33.9
trans-1,2-CPDA: 27.3
Benzoyl-CoA: 24.0
CHC-CoA: 19.4
2-Methylbutyryl-CoA: 19.0
3-Methylbutyryl-CoA: 10.9

ladSVIII

PKS_AT (560..854): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 195.5
Ethylmalonyl-CoA: 194.4
Methoxymalonyl-CoA: 155.8
2-Methylbutyryl-CoA: 124.5
trans-1,2-CPDA: 118.7
Propionyl-CoA: 117.9
CHC-CoA: 112.2
Malonyl-CoA: 93.2
Isobutyryl-CoA: 78.9
Benzoyl-CoA: 50.3
Acetyl-CoA: 46.4
fatty_acid: 43.8
3-Methylbutyryl-CoA: 34.3
inactive: 24.0

PKS_AT (2102..2397): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 212.5
Ethylmalonyl-CoA: 207.4
Methoxymalonyl-CoA: 173.8
2-Methylbutyryl-CoA: 145.1
trans-1,2-CPDA: 128.4
Propionyl-CoA: 122.8
Malonyl-CoA: 111.3
CHC-CoA: 110.7
Isobutyryl-CoA: 76.3
Benzoyl-CoA: 53.8
Acetyl-CoA: 47.8
fatty_acid: 46.9
3-Methylbutyryl-CoA: 41.8
inactive: 23.9

ladSVII

PKS_AT (564..858): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.8
Ethylmalonyl-CoA: 197.8
Methoxymalonyl-CoA: 164.7
2-Methylbutyryl-CoA: 130.9
trans-1,2-CPDA: 122.4
Propionyl-CoA: 113.7
CHC-CoA: 105.6
Malonyl-CoA: 95.5
Isobutyryl-CoA: 79.6
Acetyl-CoA: 56.7
Benzoyl-CoA: 50.9
fatty_acid: 41.7
3-Methylbutyryl-CoA: 33.2
inactive: 20.6