Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000086.1:
Cluster 1Polyketide181959

BGC0000086, lasalocid biosynthetic gene cluster from Streptomyces lasaliensis. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: lasalocid
PubChem ID: 2724110
SMILES string: Copy to clipboard
Molecular formula: C34H53NaO8
Average molecular mass: 612.78 Da

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide synthase subclass:
Type I

Gene cluster description

lasalocid (BGC0000086). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank AB449340. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

Literature references

1. Shichijo Y et al. (2008) Epoxide hydrolase Lsd19 for polyether formation in the biosynthesis of lasalocid A: direct experimental evidence on polyene-polyepoxide hypothesis in polyether biosynthesis. J Am Chem Soc 130(37):12230-1. doi: 10.1021/ja8040543. Epub 2008 Aug
2. Migita A et al. (2009) Identification of a gene cluster of polyether antibiotic lasalocid from Streptomyces lasaliensis. Biosci Biotechnol Biochem 73(1):169-76. doi: 10.1271/bbb.80631. Epub