BGC0000086 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000086 (Streptomyces lasalocidi)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	81,959	lasalocid	Polyketide	33%

BGC0000086 - Region 1 - T1PKS

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Location: 1 - 81,959 nt. (total: 81,959 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 81,960
Label		BGC0000086

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000086.1	0.83	Polyketide	lasalocid	Streptomyces lasaliensis
BGC0000087.1	0.44	Polyketide	lasalocid	Streptomyces lasaliensis
BGC0000041.1	0.35	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001273.1	0.31	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001244.1	0.31	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001276.1	0.30	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0000122.1	0.30	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0001648.1	0.30	Polyketide	lasalocid	Streptomyces sp.
BGC0001275.1	0.30	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001988.1	0.29	Polyketide	neosartorin	Aspergillus novofumigatus IBT 16806

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000086.1	0.94	Polyketide	lasalocid	Streptomyces lasaliensis
BGC0000087.1	0.75	Polyketide	lasalocid	Streptomyces lasaliensis
BGC0000041.1	0.68	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001273.1	0.64	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001244.1	0.64	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001276.1	0.64	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0000122.1	0.64	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0001648.1	0.64	Polyketide	lasalocid	Streptomyces sp.
BGC0001275.1	0.63	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001988.1	0.63	Polyketide	neosartorin	Aspergillus novofumigatus IBT 16806

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 81959:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - pk - redmal) + (Me-mal) + (pk - Me-redmal - pk) + (Me-ohmal) + (redmal - ohmal) + (Me-ccmal) + (mal)
Non-colinear ordering:: lsd11 + lsd13 + lsd12 + lsd14 + lsd15 + lsd16 + lsd17

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

lsd11

PKS_AT (443..742): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 232.3
inactive: 106.5
Methoxymalonyl-CoA: 83.3
Methylmalonyl-CoA: 66.9
Propionyl-CoA: 52.9
Isobutyryl-CoA: 43.2
Ethylmalonyl-CoA: 30.0
2-Methylbutyryl-CoA: 29.3
Benzoyl-CoA: 22.7
fatty_acid: 20.6
Acetyl-CoA: 20.3
CHC-CoA: 14.7
3-Methylbutyryl-CoA: 13.0
trans-1,2-CPDA: 0.0

PKS_AT (1489..1780): pk

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Methylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 184.0
Ethylmalonyl-CoA: 174.0
Methoxymalonyl-CoA: 148.4
2-Methylbutyryl-CoA: 119.6
trans-1,2-CPDA: 114.4
CHC-CoA: 104.0
Malonyl-CoA: 96.8
Propionyl-CoA: 90.6
Isobutyryl-CoA: 66.8
Benzoyl-CoA: 32.1
fatty_acid: 30.5
inactive: 27.7
Acetyl-CoA: 26.1
3-Methylbutyryl-CoA: 21.3

PKS_AT (3292..3578): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 189.8
inactive: 87.2
Methoxymalonyl-CoA: 49.0
Methylmalonyl-CoA: 34.4
Propionyl-CoA: 27.2
Acetyl-CoA: 17.7
fatty_acid: 17.5
Benzoyl-CoA: 14.7
trans-1,2-CPDA: 14.0
Isobutyryl-CoA: 12.3
2-Methylbutyryl-CoA: 9.4
CHC-CoA: 7.1
Ethylmalonyl-CoA: 6.0
3-Methylbutyryl-CoA: 0.0

lsd12

PKS_AT (526..817): pk

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Methylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 187.0
Ethylmalonyl-CoA: 175.0
Methoxymalonyl-CoA: 152.0
2-Methylbutyryl-CoA: 118.5
trans-1,2-CPDA: 116.8
CHC-CoA: 105.1
Malonyl-CoA: 97.8
Propionyl-CoA: 90.6
Isobutyryl-CoA: 64.8
Benzoyl-CoA: 34.7
fatty_acid: 30.8
inactive: 30.6
Acetyl-CoA: 27.0
3-Methylbutyryl-CoA: 26.9

PKS_AT (2283..2580): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.7
Ethylmalonyl-CoA: 186.2
Methoxymalonyl-CoA: 160.7
2-Methylbutyryl-CoA: 133.6
trans-1,2-CPDA: 124.5
CHC-CoA: 97.3
Propionyl-CoA: 95.5
Malonyl-CoA: 80.7
Isobutyryl-CoA: 58.1
Benzoyl-CoA: 45.4
3-Methylbutyryl-CoA: 23.5
Acetyl-CoA: 17.5
fatty_acid: 16.4
inactive: 13.9

PKS_AT (4349..4640): pk

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Methylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 186.2
Ethylmalonyl-CoA: 174.2
Methoxymalonyl-CoA: 151.1
2-Methylbutyryl-CoA: 123.7
trans-1,2-CPDA: 111.6
CHC-CoA: 106.7
Malonyl-CoA: 99.3
Propionyl-CoA: 90.6
Isobutyryl-CoA: 68.0
Benzoyl-CoA: 34.2
inactive: 32.8
fatty_acid: 31.2
Acetyl-CoA: 24.8
3-Methylbutyryl-CoA: 24.5

lsd13

PKS_AT (569..866): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 197.1
Ethylmalonyl-CoA: 183.6
Methoxymalonyl-CoA: 156.0
2-Methylbutyryl-CoA: 131.7
trans-1,2-CPDA: 122.6
Propionyl-CoA: 94.1
CHC-CoA: 93.9
Malonyl-CoA: 78.9
Isobutyryl-CoA: 58.2
Benzoyl-CoA: 44.5
3-Methylbutyryl-CoA: 22.0
Acetyl-CoA: 18.9
fatty_acid: 15.4
inactive: 12.3

lsd14

PKS_AT (567..864): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.8
Ethylmalonyl-CoA: 178.6
Methoxymalonyl-CoA: 153.7
2-Methylbutyryl-CoA: 130.4
trans-1,2-CPDA: 121.5
Propionyl-CoA: 93.8
CHC-CoA: 92.0
Malonyl-CoA: 79.4
Isobutyryl-CoA: 53.7
Benzoyl-CoA: 42.3
3-Methylbutyryl-CoA: 24.5
Acetyl-CoA: 22.5
fatty_acid: 16.4
inactive: 11.2

lsd15

PKS_AT (564..850): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 180.5
inactive: 81.5
Methoxymalonyl-CoA: 43.8
Methylmalonyl-CoA: 29.9
Propionyl-CoA: 22.4
Acetyl-CoA: 15.2
fatty_acid: 12.5
2-Methylbutyryl-CoA: 12.1
Benzoyl-CoA: 11.9
Isobutyryl-CoA: 11.7
trans-1,2-CPDA: 9.8
CHC-CoA: 0.5
Ethylmalonyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2654..2939): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 180.2
inactive: 81.2
Methoxymalonyl-CoA: 42.4
Methylmalonyl-CoA: 30.7
Propionyl-CoA: 23.0
Acetyl-CoA: 15.2
fatty_acid: 12.5
2-Methylbutyryl-CoA: 12.1
CHC-CoA: 12.0
Benzoyl-CoA: 11.9
Isobutyryl-CoA: 11.7
trans-1,2-CPDA: 11.3
Ethylmalonyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

lsd16

PKS_AT (605..902): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 196.4
Ethylmalonyl-CoA: 182.0
Methoxymalonyl-CoA: 155.0
2-Methylbutyryl-CoA: 138.1
trans-1,2-CPDA: 121.6
Propionyl-CoA: 96.9
CHC-CoA: 93.7
Malonyl-CoA: 81.3
Isobutyryl-CoA: 55.4
Benzoyl-CoA: 50.2
3-Methylbutyryl-CoA: 25.4
fatty_acid: 21.6
Acetyl-CoA: 18.1
inactive: 14.7

lsd17

PKS_AT (525..804): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 184.5
inactive: 82.7
Methoxymalonyl-CoA: 43.7
Methylmalonyl-CoA: 30.1
Propionyl-CoA: 23.1
Acetyl-CoA: 14.9
fatty_acid: 13.9
Benzoyl-CoA: 12.1
Isobutyryl-CoA: 12.0
trans-1,2-CPDA: 9.7
2-Methylbutyryl-CoA: 8.9
CHC-CoA: 6.0
Ethylmalonyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0