BGC0000087: lasalocid biosynthetic gene cluster from Streptomyces lasaliensis
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 110,927 nt. (total: 110,927 nt).
This entry is originally from NCBI GenBank FM173265.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000087
Short description lasalocid biosynthetic gene cluster from Streptomyces lasaliensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
FM173265.1
via
Compounds
  • lasalocid
Species Streptomyces lasaliensis [taxonomy]
References
Chemical products information
lasalocid Evidence:
Copy SMILES
C34H53Na1O8
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAQ64671.1
 317 - 1129 (-) hypothetical protein
    copy AA seq
    copy Nt seq
    • CAQ64672.1
    		 1471 - 2379 (-) Ku70/Ku80 protein
      copy AA seq
      copy Nt seq
      • CAQ64673.1
      		 2632 - 3312 (-) putative secreted protein
        copy AA seq
        copy Nt seq
        • CAQ64674.1
        		 3605 - 5002 (-) putative MFS-type efflux protein
          copy AA seq
          copy Nt seq
          • pseudo5478_6051
          		 5479 - 6051 (+)
            copy AA seq
            copy Nt seq
            • CAQ64676.1
            		 6061 - 7269 (-) IS10 transposase
              copy AA seq
              copy Nt seq
              • pseudo7374_7788
              		 7375 - 7788 (+)
                copy AA seq
                copy Nt seq
                • pseudo7897_9088
                		 7898 - 9088 (+)
                  copy AA seq
                  copy Nt seq
                  • pseudo9093_9519
                  		 9094 - 9519 (+)
                    copy AA seq
                    copy Nt seq
                    • CAQ64680.1
                    • las1
                    		 9538 - 10287 (-) thioesterase
                      copy AA seq
                      copy Nt seq
                      • CAQ64681.1
                      • las2
                      		 10490 - 12046 (-) putative resistance protein, transporter
                        copy AA seq
                        copy Nt seq
                        • CAQ64682.1
                        • las3
                        		 12178 - 12663 (+) putative transcriptional regulator
                          copy AA seq
                          copy Nt seq
                          • CAQ64683.1
                          • las4
                          		 13216 - 15954 (+) LuxR-family transcriptional regulator
                            copy AA seq
                            copy Nt seq
                            • CAQ64684.1
                            • las5
                            		 15965 - 17329 (+) crotonyl-CoA reductase
                              copy AA seq
                              copy Nt seq
                              • CAQ64685.1
                              • las6
                              		 17453 - 19174 (-) 3-hydroxyacyl-CoA dehydrogenase
                                copy AA seq
                                copy Nt seq
                                • CAQ64686.1
                                • lasAI
                                		 19470 - 34430 (+) lasalocid modular polyketide synthase
                                  copy AA seq
                                  copy Nt seq
                                  • CAQ64687.1
                                  • lasAII
                                  		 34479 - 50888 (+) lasalocid modular polyketide synthase
                                    copy AA seq
                                    copy Nt seq
                                    • CAQ64688.1
                                    • lasAIII
                                    		 50932 - 54258 (+) lasalocid modular polyketide synthase
                                      copy AA seq
                                      copy Nt seq
                                      • CAQ64689.1
                                      • lasAIV
                                      		 54322 - 59265 (+) lasalocid modular polyketide synthase
                                        copy AA seq
                                        copy Nt seq
                                        • CAQ64690.1
                                        • lasAV
                                        		 59390 - 70429 (+) lasalocid modular polyketide synthase
                                          copy AA seq
                                          copy Nt seq
                                          • CAQ64691.1
                                          • lasAVI
                                          		 70541 - 76174 (+) lasalocid modular polyketide synthase
                                            copy AA seq
                                            copy Nt seq
                                            • CAQ64692.1
                                            • lasAVII
                                            		 76171 - 80106 (+) lasalocid modular polyketide synthase
                                              copy AA seq
                                              copy Nt seq
                                              • CAQ64693.1
                                              • las7
                                              		 80229 - 80597 (-) hypothetical protein
                                                copy AA seq
                                                copy Nt seq
                                                • CAQ64694.1
                                                • lasC
                                                		 80792 - 82210 (+) tetronomycin epoxidase
                                                  copy AA seq
                                                  copy Nt seq
                                                  • CAQ64695.1
                                                  • lasB
                                                  		 82223 - 83071 (+) epoxide hydrolase
                                                    copy AA seq
                                                    copy Nt seq
                                                    • CAQ64696.1
                                                    		 83421 - 84350 (+) serine-type D-Ala-D-Ala carboxypeptidase
                                                      copy AA seq
                                                      copy Nt seq
                                                      • CAQ64697.1
                                                      		 84406 - 85167 (-) hypothetical protein
                                                        copy AA seq
                                                        copy Nt seq
                                                        • CAQ64698.1
                                                        		 85247 - 85972 (+) hypothetical protein
                                                          copy AA seq
                                                          copy Nt seq
                                                          • CAQ64699.1
                                                          		 86050 - 86265 (-) hypothetical protein
                                                            copy AA seq
                                                            copy Nt seq
                                                            • CAQ64700.1
                                                            		 86553 - 87341 (+) hypothetical protein
                                                              copy AA seq
                                                              copy Nt seq
                                                              • CAQ64701.1
                                                              		 87418 - 88023 (-) TetR family transcriptional regulator
                                                                copy AA seq
                                                                copy Nt seq
                                                                • CAQ64702.1
                                                                		 88177 - 88923 (+) probable glucose dehydrogenase
                                                                  copy AA seq
                                                                  copy Nt seq
                                                                  • CAQ64703.1
                                                                  		 89074 - 89643 (+) hypothetical protein
                                                                    copy AA seq
                                                                    copy Nt seq
                                                                    • CAQ64704.1
                                                                    		 89789 - 90247 (+) hypothetical protein
                                                                      copy AA seq
                                                                      copy Nt seq
                                                                      • CAQ64705.1
                                                                      		 90282 - 91271 (-) peptidase U61 LD-carboxypeptidase A
                                                                        copy AA seq
                                                                        copy Nt seq
                                                                        • CAQ64706.1
                                                                        		 91714 - 91944 (+) hypothetical protein
                                                                          copy AA seq
                                                                          copy Nt seq
                                                                          • CAQ64707.1
                                                                          		 92100 - 92255 (-) hypothetical protein
                                                                            copy AA seq
                                                                            copy Nt seq
                                                                            • CAQ64708.1
                                                                            		 92919 - 93482 (-) TetR family transcriptional regulator
                                                                              copy AA seq
                                                                              copy Nt seq
                                                                              • CAQ64709.1
                                                                              		 93475 - 94311 (-) hydrolase
                                                                                copy AA seq
                                                                                copy Nt seq
                                                                                • CAQ64710.1
                                                                                		 94763 - 95233 (+) hypothetical protein
                                                                                  copy AA seq
                                                                                  copy Nt seq
                                                                                  • CAQ64711.1
                                                                                  		 95386 - 95733 (+) hypothetical protein
                                                                                    copy AA seq
                                                                                    copy Nt seq
                                                                                    • CAQ64712.1
                                                                                    		 96014 - 96328 (-) hypothetical protein
                                                                                      copy AA seq
                                                                                      copy Nt seq
                                                                                      • CAQ64713.1
                                                                                      		 96688 - 97188 (-) cupin domain protein
                                                                                        copy AA seq
                                                                                        copy Nt seq
                                                                                        • CAQ64714.1
                                                                                        		 97517 - 98020 (-) MarR family transcriptional regulator
                                                                                          copy AA seq
                                                                                          copy Nt seq
                                                                                          • CAQ64715.1
                                                                                          		 98348 - 99292 (+) alcohol dehydrogenase zinc-binding domain protein
                                                                                            copy AA seq
                                                                                            copy Nt seq
                                                                                            • CAQ64716.1
                                                                                            		 99585 - 100478 (-) AraC family transcriptional regulator
                                                                                              copy AA seq
                                                                                              copy Nt seq
                                                                                              • CAQ64717.1
                                                                                              		 101038 - 104343 (+) glycoside hydrolase family 2, sugar binding
                                                                                                copy AA seq
                                                                                                copy Nt seq
                                                                                                • CAQ64718.1
                                                                                                		 104531 - 105610 (+) sugar ABC transporter, solute-binding protein
                                                                                                  copy AA seq
                                                                                                  copy Nt seq
                                                                                                  • CAQ64719.1
                                                                                                  • rbsA
                                                                                                  		 105689 - 107377 (+) sugar uptake ABC transporter, ATP-binding protein
                                                                                                    copy AA seq
                                                                                                    copy Nt seq
                                                                                                    • CAQ64720.1
                                                                                                    		 107374 - 108342 (+) sugar uptake ABC transporter, permease protein
                                                                                                      copy AA seq
                                                                                                      copy Nt seq
                                                                                                      • CAQ64721.1
                                                                                                      • rbsC
                                                                                                      		 108339 - 109364 (+) sugar ABC transporter, permease protein
                                                                                                        copy AA seq
                                                                                                        copy Nt seq
                                                                                                        • CAQ64722.1
                                                                                                        		 109429 - 110445 (+) LacI-family transcriptional regulator
                                                                                                          copy AA seq
                                                                                                          copy Nt seq
                                                                                                          • CAQ64723.1
                                                                                                          • adpA
                                                                                                          		 110467 - >110925 (-) AraC family transcriptional regulator
                                                                                                            copy AA seq
                                                                                                            copy Nt seq
                                                                                                            Biosynthesis information
                                                                                                            Annotation changelog

                                                                                                            Entry version: 4

                                                                                                            Date
                                                                                                            Changes
                                                                                                            Submitters
                                                                                                            Reviewers
                                                                                                            2022-10-07
                                                                                                            Update chemical activity to schema version 2.11
                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                            Entry version: 3

                                                                                                            Date
                                                                                                            Changes
                                                                                                            Submitters
                                                                                                            Reviewers
                                                                                                            2022-09-15
                                                                                                            Removed gene annotations, including 'extra' genes, which duplicated NCBI annotations
                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                            2022-09-15
                                                                                                            Updated bioactivity data
                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                            Entry version: 2

                                                                                                            Date
                                                                                                            Changes
                                                                                                            Submitters
                                                                                                            Reviewers
                                                                                                            2019-10-16
                                                                                                            Migrated from v1.4
                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                            2019-10-16
                                                                                                            Updated reference publication(s) (MIBiG Annotathon)
                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                            Entry version: 1

                                                                                                            Date
                                                                                                            Changes
                                                                                                            Submitters
                                                                                                            Reviewers
                                                                                                            2015-06-12
                                                                                                            Submitted
                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                            Detailed domain annotation
                                                                                                            Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                                                                            A domain glossary is available here, and an explanation of the visualisation is available here.
                                                                                                            Selected features only
                                                                                                            Show module domains
                                                                                                            Similar known gene clusters from MIBiG 4.0
                                                                                                            Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                                                                            Click on reference genes to show details of similarities to genes within the current region.
                                                                                                            Click on an accession to open that entry in the MiBIG database.