BGC0000088 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000088 (Aspergillus terreus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	55,428	monacolin K	Polyketide	88%

BGC0000088 - Region 1 - T1PKS

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Location: 1 - 55,428 nt. (total: 55,428 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 55,429
Label		BGC0000088

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000088.1	0.67	Polyketide	monacolin K	Aspergillus terreus
BGC0001909.1	0.32	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001858.1	0.30	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001277.1	0.29	Terpene	nivalenol, vomitoxin, 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, neosolaniol, calonectrin, apotrichodiol, isotrichotriol, 15-deacetylcalonectrin, T-2 toxin, 3-acetyl T-2 toxin, trichodiene	Fusarium graminearum
BGC0000685.1	0.28	Terpene	brassicicene C	Alternaria brassicicola ATCC 96836
BGC0000098.1	0.27	Polyketide	monacolin K	Monascus pilosus
BGC0001604.1	0.25	Terpene	gibberellin	Fusarium fujikuroi
BGC0001995.1	0.25	Terpene	heptelidic acid	Aspergillus oryzae RIB40
BGC0001141.1	0.24	Polyketide	4-epi-15-epi-brefeldin A	Penicillium brefeldianum
BGC0000003.1	0.23	Polyketide	AF-toxin	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000088.1	0.87	Polyketide	monacolin K	Aspergillus terreus
BGC0001909.1	0.65	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001858.1	0.63	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001277.1	0.62	Terpene	nivalenol, vomitoxin, 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, neosolaniol, calonectrin, apotrichodiol, isotrichotriol, 15-deacetylcalonectrin, T-2 toxin, 3-acetyl T-2 toxin, trichodiene	Fusarium graminearum
BGC0000685.1	0.61	Terpene	brassicicene C	Alternaria brassicicola ATCC 96836
BGC0000098.1	0.60	Polyketide	monacolin K	Monascus pilosus
BGC0001604.1	0.59	Terpene	gibberellin	Fusarium fujikuroi
BGC0001995.1	0.59	Terpene	heptelidic acid	Aspergillus oryzae RIB40
BGC0001141.1	0.57	Polyketide	4-epi-15-epi-brefeldin A	Penicillium brefeldianum
BGC0000003.1	0.56	Polyketide	AF-toxin	Alternaria alternata

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 8529 - 55428:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

lovF

PKS_AT (544..869): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 92.0
Methoxymalonyl-CoA: 52.9
Methylmalonyl-CoA: 52.8
Isobutyryl-CoA: 35.0
Propionyl-CoA: 19.3
inactive: 18.9
Benzoyl-CoA: 13.0
fatty_acid: 12.7
3-Methylbutyryl-CoA: 9.1
Ethylmalonyl-CoA: 5.7
2-Methylbutyryl-CoA: 3.8
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0