BGC0001141: 4-epi-15-epi-brefeldin A biosynthetic gene cluster from Penicillium brefeldianum
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Location: 1 - 37,663 nt. (total: 37,663 nt).
This entry is originally from NCBI GenBank KJ728786.1.

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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001141
Short description 4-epi-15-epi-brefeldin A biosynthetic gene cluster from Penicillium brefeldianum
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: KJ728786.1
Compounds
  • 4-epi-15-epi-brefeldin A
Species Penicillium brefeldianum [taxonomy]
References
Chemical products information
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4-epi-15-epi-brefeldin A
Molecular Formula C16H5O4
Chemical database entries NPAtlas  
List of genes involved in compound(s) production
Identifiers Position Product Functions Extra
  • AIA58894.1
263 2905 + putative F-box domain protein
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  • AIA58903.1
3699 4681 - thiohydrolase
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  • AIA58895.1
5541 7257 + putative cytochrome P450
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  • AIA58896.1
7855 9494 + putative cytochrome P450
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  • AIA58897.1
10514 12193 + putative cytochrome P450
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  • AIA58898.1
12965 14473 - putative cytochrome P450
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  • AIA58899.1
16191 23507 + HRPKS
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  • AIA58900.1
24185 25201 - putative large tegument protein UL36
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  • AIA58901.1
29688 34538 - putative WD-40 protein
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  • AIA58902.1
36036 37660 + putative kinesin
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? yes
Release type
  • Macrolactonization
Polyketide-synthases
Genes Properties Modules
aia58903
+
AIA58899
+
aia58899
Synthase subclass: Iterative type I
Thioesterases:
  • aia58903 (Unknown)
Iterative PKS type: Highly reducing, Unknown
Iteration counts: 7
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Activity assay
Genes: AIA58899
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Annotation changelog
MIBiG version Notes
2.0
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
Detailed domain annotation
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