BGC0000093: meilingmycin biosynthetic gene cluster from Streptomyces nanchangensis
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Location: 1 - 185,250 nt. (total: 185,250 nt).
This entry is originally from NCBI GenBank FJ952082.1.

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core biosynthetic genes
additional biosynthetic genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000093
Short description meilingmycin biosynthetic gene cluster from Streptomyces nanchangensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
FJ952082.1
via
Compounds
  • meilingmycin
  • Meilingmycin A
  • Meilingmycin B
  • Meilingmycin E
  • Meilingmycin D
  • Meilingmycin C
Species Streptomyces nanchangensis [taxonomy]
References
Chemical products information
meilingmycin Evidence: NMR [1]
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C36H52O8
Chemical database entries
PubCHEM
Meilingmycin A Evidence: NMR [1]
(no structure information available)
Meilingmycin B Evidence: NMR [1]
(no structure information available)
Meilingmycin E Evidence: NMR [1]
(no structure information available)
Meilingmycin D Evidence: NMR [1]
(no structure information available)
Meilingmycin C Evidence: NMR [1]
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADC45511.1
 1 - 1337 (-) Na+/H+ antiporter
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    • ADC45512.1
    		 1603 - 2280 (-) intracellular protease/amidase
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      • ADC45513.1
      		 2432 - 3331 (+) LysR-family transcriptional regulator
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        • ADC45514.1
        		 3487 - 4683 (+) cytochrome P450
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          • ADC45515.1
          • pks2
          		 4699 - 10563 (-) modular polyketide synthase
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            • ADC45516.1
            • pks1
            		 10556 - 17425 (-) modular polyketide synthase
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              • ADC45517.1
              		 17671 - 19389 (+) AMP-dependent synthetase and ligase
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                • ADC45518.1
                		 19386 - 20252 (+) hypothetical protein
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                  • ADC45519.1
                  		 20249 - 20779 (+) thioesterase
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                    • ADC45520.1
                    		 20776 - 21066 (+) acyl carrier protein
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                      • ADC45521.1
                      		 21063 - 21932 (+) cyclopropane-fatty-acyl-phospholipid synthase
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                        • ADC45522.1
                        		 21929 - 22801 (+) acyl-[acyl-carrier protein] desaturase
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                          • ADC45523.1
                          		 22816 - 24429 (-) secreted amidase
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                            • ADC45524.1
                            		 24504 - 25007 (-) hypothetical protein
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                              • ADC45525.1
                              		 25161 - 27209 (+) alpha-glucuronidase
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                                • ADC45526.1
                                		 27238 - 31071 (-) hypothetical protein
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                                  • ADC45527.1
                                  		 31153 - 32580 (-) gluconate transporter
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                                    • ADC45528.1
                                    		 32668 - 33654 (-) hypothetical protein
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                                      • ADC45529.1
                                      		 33753 - 35426 (+) two-component system histidine kinase
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                                        • ADC45530.1
                                        		 35423 - 36115 (+) two-component system response regulator
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                                          • ADC45531.1
                                          		 36139 - 37263 (-) hypothetical protein
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                                            • ADC45532.1
                                            		 37274 - 37849 (-) heavy metal translocating P-type ATPase
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                                              • ADC45533.1
                                              		 38044 - 39195 (+) hypothetical protein
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                                                • ADC45534.1
                                                • meiA2
                                                		 39452 - 57415 (+) modular polyketide synthase
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                                                  • AAM97313.1
                                                  • meiC
                                                  		 57429 - 58421 (+) post-polyketide modification protein
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                                                    • AAM97314.1
                                                    • meiE
                                                    		 58480 - 59859 (-) cytochrome P450 hydroxylase
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                                                      • ADC45535.1
                                                      • meiA4
                                                      		 59936 - 75769 (-) modular polyketide synthase
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                                                        • ADC45536.1
                                                        		 76029 - 76829 (+) reductase
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                                                          • AAP13848.2
                                                          • meiF
                                                          		 76867 - 77679 (-) C5-ketoreductase
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                                                            • ADC45537.1
                                                            		 77846 - 78601 (-) hypothetical protein
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                                                              • ADC45538.1
                                                              • meiA3
                                                              		 78606 - 96074 (-) modular polyketide synthase
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                                                                • ADC45539.1
                                                                • meiR
                                                                		 96121 - 99015 (-) LuxR-family transcriptional regulator
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                                                                  • ADC45540.1
                                                                  		 99318 - 100469 (+) hypothetical protein
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                                                                    • ADC45541.1
                                                                    		 100671 - 102113 (+) beta-lactamase-like protein
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                                                                      • ADC45542.1
                                                                      		 102173 - 103669 (-) Na+/solute symporter
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                                                                        • ADC45543.1
                                                                        		 103666 - 103896 (-) hypothetical protein
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                                                                          • ADC45544.1
                                                                          		 104276 - 104656 (+) hypothetical protein
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                                                                            • ADC45545.1
                                                                            		 104656 - 105486 (+) hydroxypyruvate isomerase
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                                                                              • ADC45546.1
                                                                              		 105556 - 106452 (+) 2-hydroxy-3-oxopropionate reductase
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                                                                                • ADC45547.1
                                                                                		 106518 - 108287 (+) glyoxylate carboligase
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                                                                                  • ADC45548.1
                                                                                  		 108318 - 109508 (-) mandelate racemase
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                                                                                    • ADC45549.1
                                                                                    		 109505 - 110284 (-) 5-carboxymethyl-2-hydroxymuconate delta-isomerase
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                                                                                      • ADC45550.1
                                                                                      		 110464 - 111825 (-) anion/cation symporter
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                                                                                        • ADC45551.1
                                                                                        		 112100 - 112885 (+) dimethylmenaquinone methyltransferase
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                                                                                          • ADC45552.1
                                                                                          		 112882 - 113391 (+) hypothetical protein
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                                                                                            • ADC45553.1
                                                                                            		 113420 - 114931 (+) aldehyde dehydrogenase
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                                                                                              • ADC45554.1
                                                                                              		 114915 - 115772 (-) aldose 1-epimerase
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                                                                                                • ADC45555.1
                                                                                                		 115938 - 117386 (+) sugar transporter
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                                                                                                  • ADC45556.1
                                                                                                  		 117383 - 118279 (+) 2-hydroxycyclohexanecarboxyl-CoA dehyrogenase
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                                                                                                    • ADC45557.1
                                                                                                    		 118276 - 119445 (+) isomerase
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                                                                                                      • ADC45558.1
                                                                                                      		 119490 - 120278 (-) transcriptional regulator
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                                                                                                        • ADC45559.1
                                                                                                        		 120722 - 121447 (-) acetyl-xylan esterase
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                                                                                                          • ADC45560.1
                                                                                                          		 121600 - 122463 (-) citrate lyase beta subunit
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                                                                                                            • ADC45561.1
                                                                                                            		 122516 - 123400 (-) hypothetical protein
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                                                                                                              • ADC45562.1
                                                                                                              		 123478 - 124077 (-) sulfopyruvate decarboxylase beta subunit
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                                                                                                                • ADC45563.1
                                                                                                                		 124077 - 124613 (-) sulfopyruvate decarboxylase alpha subunit
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                                                                                                                  • ADC45564.1
                                                                                                                  		 124725 - 125549 (-) hydrolase
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                                                                                                                    • ADC45565.1
                                                                                                                    		 125629 - 126582 (-) LysR-family transcriptional regulator
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                                                                                                                      • ADC45566.1
                                                                                                                      		 126703 - 127887 (+) L-carnitine dehydratase
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                                                                                                                        • ADC45567.1
                                                                                                                        		 127932 - 129095 (+) acyl-CoA dehydrogenase
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                                                                                                                          • ADC45568.1
                                                                                                                          		 129165 - 132380 (-) rhamnosidase
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                                                                                                                            • ADC45569.1
                                                                                                                            		 132620 - 132940 (-) hypothetical protein
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                                                                                                                              • ADC45570.1
                                                                                                                              		 133101 - 133751 (-) transcriptional regulator
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                                                                                                                                • ADC45571.1
                                                                                                                                		 133941 - 134603 (+) hypothetical protein
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                                                                                                                                  • ADC45572.1
                                                                                                                                  		 134605 - 135198 (-) TetR-family transcriptional regulator
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                                                                                                                                    • ADC45573.1
                                                                                                                                    		 135388 - 136407 (+) aldoketoreductase
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                                                                                                                                      • ADC45574.1
                                                                                                                                      		 136478 - 137323 (+) flavin-dependent oxidoreductase
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                                                                                                                                        • ADC45575.1
                                                                                                                                        		 137355 - 138866 (-) hydrolase
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                                                                                                                                          • ADC45576.1
                                                                                                                                          		 139224 - 140276 (+) hypothetical protein
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                                                                                                                                            • ADC45577.1
                                                                                                                                            		 140258 - 141583 (+) hypothetical protein
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                                                                                                                                              • ADC45578.1
                                                                                                                                              		 141628 - 142818 (+) lysine/ornithine decarboxylase
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                                                                                                                                                • ADC45579.1
                                                                                                                                                		 142827 - 143357 (+) hypothetical protein
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                                                                                                                                                  • ADC45580.1
                                                                                                                                                  		 143354 - 144553 (+) transmembrane transport protein
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                                                                                                                                                    • ADC45581.1
                                                                                                                                                    		 144519 - 145820 (-) glycoside hydrolase
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                                                                                                                                                      • ADC45582.1
                                                                                                                                                      		 145963 - 148932 (-) hypothetical protein
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                                                                                                                                                        • ADC45583.1
                                                                                                                                                        		 149148 - 150152 (+) sugar-binding transcriptional regulator
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                                                                                                                                                          • ADC45584.1
                                                                                                                                                          		 150307 - 152142 (+) monooxygenase
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                                                                                                                                                            • ADC45585.1
                                                                                                                                                            		 152139 - 153836 (+) hypothetical protein
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                                                                                                                                                              • ADC45586.1
                                                                                                                                                              • meiA1
                                                                                                                                                              		 154052 - 167044 (+) modular polyketide synthase
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                                                                                                                                                                • ADC45587.1
                                                                                                                                                                • meiD
                                                                                                                                                                		 167087 - 167947 (+) C5-O-methyltransferase
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                                                                                                                                                                  • ADC45588.1
                                                                                                                                                                  		 167960 - 171655 (-) hydrolase
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                                                                                                                                                                    • ADC45589.1
                                                                                                                                                                    		 171713 - 172498 (-) short-chain dehydrogenase/reductase SDR
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                                                                                                                                                                      • ADC45590.1
                                                                                                                                                                      		 172569 - 174362 (-) beta-glucuronidase precursor
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                                                                                                                                                                        • ADC45591.1
                                                                                                                                                                        		 174404 - 175621 (-) beta-glucosidase
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                                                                                                                                                                          • ADC45592.1
                                                                                                                                                                          		 175618 - 176493 (-) ABC transporter
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                                                                                                                                                                            • ADC45593.1
                                                                                                                                                                            		 176490 - 178325 (-) ABC transporter
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                                                                                                                                                                              • ADC45594.1
                                                                                                                                                                              		 178322 - 179278 (-) transporter
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                                                                                                                                                                                • ADC45595.1
                                                                                                                                                                                		 179275 - 180837 (-) extracellular solute-binding protein
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                                                                                                                                                                                  • ADC45596.1
                                                                                                                                                                                  		 181085 - 181693 (+) TetR-family transcriptional regulator
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                                                                                                                                                                                    • ADC45597.1
                                                                                                                                                                                    		 181698 - 182726 (-) LacI-family transcriptional regulator
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                                                                                                                                                                                      • ADC45598.1
                                                                                                                                                                                      		 182934 - 183905 (+) carbohydrate kinase
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                                                                                                                                                                                        • ADC45599.1
                                                                                                                                                                                        		 183922 - 184824 (+) hypothetical protein
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                                                                                                                                                                                          Biosynthesis information
                                                                                                                                                                                          Annotation changelog

                                                                                                                                                                                          Entry version: next

                                                                                                                                                                                          Date
                                                                                                                                                                                          Changes
                                                                                                                                                                                          Submitters
                                                                                                                                                                                          Reviewers
                                                                                                                                                                                          2024-05-14
                                                                                                                                                                                          MIBiG v4 annotathon
                                                                                                                                                                                          • (ID: 2QMTKRHHEW7SVXJII2W6QJDH)
                                                                                                                                                                                          • (ID: P75FRHHCFPTCPYSP65VDVPHW)
                                                                                                                                                                                          • (ID: MGLE5JJ3S32DQA3YR5WPYH4W)
                                                                                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                                                                          Entry version: 4

                                                                                                                                                                                          Date
                                                                                                                                                                                          Changes
                                                                                                                                                                                          Submitters
                                                                                                                                                                                          Reviewers
                                                                                                                                                                                          2022-10-07
                                                                                                                                                                                          Update chemical activity to schema version 2.11
                                                                                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                                                                          Entry version: 3

                                                                                                                                                                                          Date
                                                                                                                                                                                          Changes
                                                                                                                                                                                          Submitters
                                                                                                                                                                                          Reviewers
                                                                                                                                                                                          2022-09-15
                                                                                                                                                                                          Updated bioactivity data
                                                                                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                                                                          Entry version: 2

                                                                                                                                                                                          Date
                                                                                                                                                                                          Changes
                                                                                                                                                                                          Submitters
                                                                                                                                                                                          Reviewers
                                                                                                                                                                                          2019-10-16
                                                                                                                                                                                          Migrated from v1.4
                                                                                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                                                          2019-10-16
                                                                                                                                                                                          Updated compound(s) information (NPAtlas curation)
                                                                                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                                                                          Entry version: 1

                                                                                                                                                                                          Date
                                                                                                                                                                                          Changes
                                                                                                                                                                                          Submitters
                                                                                                                                                                                          Reviewers
                                                                                                                                                                                          2015-06-12
                                                                                                                                                                                          Submitted
                                                                                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                                                          Detailed domain annotation
                                                                                                                                                                                          Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
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