BGC0000093 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000093 (Streptomyces nanchangensis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	185,250	LL-F28249α	Polyketide	91%

BGC0000093 - Region 1 - T1PKS

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Location: 1 - 185,250 nt. (total: 185,250 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 185,251
Label		BGC0000093

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000093.1	0.98	Polyketide	meilingmycin	Streptomyces nanchangensis
BGC0000041.1	0.91	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001647.1	0.76	Polyketide	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0001544.1	0.74	NRP, Polyketide	chlorflavonin	Aspergillus campestris IBT 28561
BGC0000122.1	0.69	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0001276.1	0.66	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0000197.1	0.61	Polyketide, Saccharide	aranciamycin	Streptomyces echinatus
BGC0001162.1	0.60	Polyketide	1-heptadecene	Moorea producens JHB
BGC0000160.1	0.59	Polyketide	terreic acid	Aspergillus terreus NIH2624
BGC0001377.1	0.58	Polyketide	uncialamycin	Streptomyces uncialis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000093.1	0.96	Polyketide	meilingmycin	Streptomyces nanchangensis
BGC0000041.1	0.69	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000122.1	0.65	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0001647.1	0.65	Polyketide	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0000160.1	0.65	Polyketide	terreic acid	Aspergillus terreus NIH2624
BGC0000120.1	0.64	Polyketide	patulin	Penicillium expansum
BGC0001276.1	0.64	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001340.1	0.64	Polyketide	byssochlamic acid	Byssochlamys fulva
BGC0001164.1	0.63	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001273.1	0.63	Polyketide	asperlactone	Aspergillus ochraceus

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location <0 - 115772:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ohmal) + (ohmal - Me-ohmal - ccmal) + (mal - ohmal - ohmal - Me-ccmal) + (Me-redmal - ccmal - Me-ccmal) + (Me-ccmal)
Non-colinear ordering:: pks1 + meiA4 + meiA2 + meiA3 + pks2

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location <0 - 37263:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ohmal) + (Me-ccmal)
Non-colinear ordering:: pks1 + pks2

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 20248 - 115772:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ohmal - ohmal - Me-ccmal) + (Me-redmal - ccmal - Me-ccmal) + (ohmal - Me-ohmal - ccmal)
Non-colinear ordering:: meiA2 + meiA3 + meiA4

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 134051 - 185250:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - Me-ohmal - redmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

pks2

PKS_AT (543..834): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 188.1
Ethylmalonyl-CoA: 180.0
Methoxymalonyl-CoA: 162.9
2-Methylbutyryl-CoA: 137.0
trans-1,2-CPDA: 125.3
Propionyl-CoA: 97.1
Malonyl-CoA: 95.6
CHC-CoA: 90.1
Isobutyryl-CoA: 77.9
Benzoyl-CoA: 61.6
fatty_acid: 26.9
Acetyl-CoA: 25.7
inactive: 23.4
3-Methylbutyryl-CoA: 16.2

pks1

PKS_AT (366..661): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 113.4
Methylmalonyl-CoA: 37.4
inactive: 37.2
Methoxymalonyl-CoA: 34.3
Propionyl-CoA: 16.8
Ethylmalonyl-CoA: 14.7
Acetyl-CoA: 13.5
Isobutyryl-CoA: 13.3
Benzoyl-CoA: 11.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (1339..1625): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.9
inactive: 105.9
Methoxymalonyl-CoA: 67.6
Methylmalonyl-CoA: 47.2
Propionyl-CoA: 30.7
fatty_acid: 20.5
Isobutyryl-CoA: 16.6
2-Methylbutyryl-CoA: 16.5
Ethylmalonyl-CoA: 16.4
Acetyl-CoA: 16.3
CHC-CoA: 11.5
Benzoyl-CoA: 11.2
3-Methylbutyryl-CoA: 10.1
trans-1,2-CPDA: 0.0

ADC45517.1

CAL_domain (151..473): pk

minowa: NH2

Prediction, score:

NH2: 67.4
fatty_acid: 19.9
Acetyl-CoA: 14.7
shikimic_acid: 0.0
AHBA: 0.0

meiA2

PKS_AT (564..850): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 66.7%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 164.3
Methoxymalonyl-CoA: 66.6
inactive: 62.0
Methylmalonyl-CoA: 50.8
Ethylmalonyl-CoA: 23.8
Acetyl-CoA: 22.3
Isobutyryl-CoA: 19.1
Propionyl-CoA: 18.4
Benzoyl-CoA: 15.1
fatty_acid: 12.7
CHC-CoA: 11.6
2-Methylbutyryl-CoA: 11.5
trans-1,2-CPDA: 6.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (1576..1862): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 66.7%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 165.2
Methoxymalonyl-CoA: 67.1
inactive: 60.8
Methylmalonyl-CoA: 51.1
Ethylmalonyl-CoA: 25.0
Acetyl-CoA: 23.2
Propionyl-CoA: 19.5
Isobutyryl-CoA: 19.4
fatty_acid: 14.7
Benzoyl-CoA: 14.6
2-Methylbutyryl-CoA: 11.9
CHC-CoA: 11.4
trans-1,2-CPDA: 9.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (3111..3397): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 62.5%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 160.4
Methoxymalonyl-CoA: 65.8
inactive: 59.4
Methylmalonyl-CoA: 49.4
Acetyl-CoA: 26.4
Ethylmalonyl-CoA: 26.2
Propionyl-CoA: 23.5
Isobutyryl-CoA: 22.0
fatty_acid: 19.9
CHC-CoA: 13.2
2-Methylbutyryl-CoA: 13.0
Benzoyl-CoA: 11.3
trans-1,2-CPDA: 8.1
3-Methylbutyryl-CoA: 0.0

PKS_AT (4626..4924): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 194.0
Ethylmalonyl-CoA: 180.2
Methoxymalonyl-CoA: 167.5
2-Methylbutyryl-CoA: 138.9
trans-1,2-CPDA: 115.5
Propionyl-CoA: 111.5
Malonyl-CoA: 100.5
CHC-CoA: 94.6
Isobutyryl-CoA: 71.0
Benzoyl-CoA: 52.0
inactive: 38.4
Acetyl-CoA: 33.3
fatty_acid: 22.6
3-Methylbutyryl-CoA: 13.5

meiA4

PKS_AT (571..872): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 224.7
inactive: 112.6
Methoxymalonyl-CoA: 64.3
Methylmalonyl-CoA: 52.8
Isobutyryl-CoA: 31.6
Propionyl-CoA: 30.6
Benzoyl-CoA: 30.5
Ethylmalonyl-CoA: 24.9
Acetyl-CoA: 18.0
2-Methylbutyryl-CoA: 13.6
fatty_acid: 13.0
trans-1,2-CPDA: 10.2
CHC-CoA: 6.7
3-Methylbutyryl-CoA: 0.0

PKS_AT (2121..2419): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 191.3
Ethylmalonyl-CoA: 189.3
Methoxymalonyl-CoA: 165.1
2-Methylbutyryl-CoA: 134.1
CHC-CoA: 105.9
trans-1,2-CPDA: 105.5
Malonyl-CoA: 99.1
Isobutyryl-CoA: 95.0
Propionyl-CoA: 89.9
Benzoyl-CoA: 53.5
3-Methylbutyryl-CoA: 48.7
Acetyl-CoA: 43.2
fatty_acid: 42.6
inactive: 25.0

PKS_AT (3649..3936): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 200.5
inactive: 89.2
Methoxymalonyl-CoA: 61.3
Methylmalonyl-CoA: 48.9
Isobutyryl-CoA: 35.8
Ethylmalonyl-CoA: 25.5
Propionyl-CoA: 23.8
Acetyl-CoA: 19.2
Benzoyl-CoA: 17.7
CHC-CoA: 13.6
2-Methylbutyryl-CoA: 13.1
fatty_acid: 12.8
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

meiA3

PKS_AT (589..887): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 207.8
Ethylmalonyl-CoA: 201.4
Methoxymalonyl-CoA: 173.3
trans-1,2-CPDA: 152.4
2-Methylbutyryl-CoA: 138.1
Malonyl-CoA: 116.5
Propionyl-CoA: 111.6
CHC-CoA: 91.4
Isobutyryl-CoA: 80.1
Benzoyl-CoA: 67.5
Acetyl-CoA: 42.9
3-Methylbutyryl-CoA: 36.0
inactive: 35.8
fatty_acid: 21.7

PKS_AT (2698..2984): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 66.7%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 166.8
Methoxymalonyl-CoA: 67.3
inactive: 62.3
Methylmalonyl-CoA: 51.8
Ethylmalonyl-CoA: 24.9
Acetyl-CoA: 24.1
Isobutyryl-CoA: 20.8
Propionyl-CoA: 20.4
fatty_acid: 15.1
Benzoyl-CoA: 15.0
CHC-CoA: 11.5
2-Methylbutyryl-CoA: 11.4
trans-1,2-CPDA: 6.7
3-Methylbutyryl-CoA: 0.0

PKS_AT (4491..4789): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 194.0
Ethylmalonyl-CoA: 180.2
Methoxymalonyl-CoA: 167.5
2-Methylbutyryl-CoA: 138.9
trans-1,2-CPDA: 115.5
Propionyl-CoA: 111.5
Malonyl-CoA: 100.5
CHC-CoA: 94.6
Isobutyryl-CoA: 71.0
Benzoyl-CoA: 52.0
inactive: 38.4
Acetyl-CoA: 33.3
fatty_acid: 22.6
3-Methylbutyryl-CoA: 13.5

meiA1

PKS_AT (93..391): mmal

ATSignature: 2-Methylbutyryl-CoA

Top 3 matches:: 2-Methylbutyryl-CoA: 70.8%; Methylmalonyl-CoA: 62.5%; Isobutyryl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 155.4
Ethylmalonyl-CoA: 153.8
2-Methylbutyryl-CoA: 140.2
Methoxymalonyl-CoA: 130.8
trans-1,2-CPDA: 115.2
Propionyl-CoA: 98.5
CHC-CoA: 93.8
Malonyl-CoA: 63.7
Acetyl-CoA: 57.7
Benzoyl-CoA: 53.7
Isobutyryl-CoA: 53.0
3-Methylbutyryl-CoA: 23.1
fatty_acid: 15.8
inactive: 10.0

PKS_AT (1114..1412): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 201.9
Ethylmalonyl-CoA: 191.7
Methoxymalonyl-CoA: 168.9
2-Methylbutyryl-CoA: 147.7
Propionyl-CoA: 120.3
trans-1,2-CPDA: 116.4
Malonyl-CoA: 99.1
CHC-CoA: 96.4
Isobutyryl-CoA: 79.8
Benzoyl-CoA: 63.1
Acetyl-CoA: 49.9
3-Methylbutyryl-CoA: 34.4
fatty_acid: 33.9
inactive: 24.9

PKS_AT (2675..2977): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 136.3
inactive: 54.0
Methoxymalonyl-CoA: 44.9
Methylmalonyl-CoA: 33.7
Propionyl-CoA: 22.8
Acetyl-CoA: 17.2
Ethylmalonyl-CoA: 16.0
2-Methylbutyryl-CoA: 10.0
Isobutyryl-CoA: 5.2
CHC-CoA: 2.7
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0