BGC0000094: methymycin biosynthetic gene cluster from Streptomyces venezuelae
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Location: 1 - 37,948 nt. (total: 37,948 nt).
This entry is originally from NCBI GenBank AF079138.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000094
Short description methymycin biosynthetic gene cluster from Streptomyces venezuelae
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: partial
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
  • saccharide (hybrid/tailoring)
Loci
AF079138.1
via Enzymatic assays
Compounds
  • methymycin
Species Streptomyces venezuelae [taxonomy]
References
Chemical products information
methymycin Evidence:
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C25H43N1O7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAC69327.1
  • pikR2
 154 - 1122 (+) rRNA methyltransferase PikR2
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    • AAC69328.1
    • pikR1
    		 1283 - 2293 (-) rRNA methyltransferase PikR1
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      • AAC69329.1
      • pikAI
      		 2912 - 16753 (+) type I polyketide synthase PikAI
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        • AAC69330.1
        • pikAII
        		 16858 - 28077 (+) type I polyketide synthase PikAII
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          • AAC69331.1
          • pikAIII
          		 28161 - 32849 (+) type I polyketide synthase PikAIII
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            • AAC69332.1
            • pikAIV
            		 32952 - 36992 (+) type I polyketide synthase PikAIV
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              • AAC69333.1
              • pikAV
              		 36989 - 37834 (+) thioesterase II PikAV
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                Biosynthesis information

                Biosynthetic modules

                Name
                0
                Type
                pks-modular
                Genes
                pikAI
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                Name
                1
                Type
                pks-modular
                Genes
                pikAI
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                Name
                2
                Type
                pks-modular
                Genes
                pikAI
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                Name
                3
                Type
                pks-modular
                Genes
                pikAII
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                Name
                4
                Type
                pks-modular
                Genes
                pikAII
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                Name
                5
                Type
                pks-modular
                Genes
                pikAIII
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                Name
                6
                Type
                pks-modular
                Genes
                pikAIV
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                Annotation changelog

                Entry version: 4

                Date
                Changes
                Submitters
                Reviewers
                2022-10-07
                Update chemical activity to schema version 2.11
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 3

                Date
                Changes
                Submitters
                Reviewers
                2022-09-15
                Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 2

                Date
                Changes
                Submitters
                Reviewers
                2019-10-16
                Migrated from v1.4
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2019-10-16
                Updated compound(s) information (NPAtlas curation)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 1

                Date
                Changes
                Submitters
                Reviewers
                2015-06-12
                Submitted
                • (ID: RIBLHRV4YSJAGJ5EVZV4GS2Z)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                Detailed domain annotation
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