BGC0000098 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000098 (Monascus pilosus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	45,000	High	monacolin K	PKS

BGC0000098 - Region 1 - T1PKS

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Location: 1 - 45,000 nt. (total: 45,000 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 45,001
Label		BGC0000098

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase reductase

mkC: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

mkE: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

mkG: hydroxymethylglutaryl-CoA reductase

smcogs: SMCOG1187: hydroxymethylglutaryl-CoA reductase

Hydrolases: hydrolase

mkF: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Ligases: synthase

mkA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

mkB: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000098.3	1.25	PKS	monacolin K	Monascus pilosus
BGC0002192.3	0.79	PKS	FR901512	fungal sp. No.14919
BGC0002191.2	0.74	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001254.3	0.72	PKS	ACT-Toxin II	Alternaria alternata
BGC0000088.4	0.70	PKS	lovastatin	Aspergillus terreus
BGC0001268.4	0.65	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001275.3	0.62	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.62	PKS	asperlactone	Aspergillus ochraceus
BGC0001160.5	0.56	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.56	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000098.3	0.99	PKS	monacolin K	Monascus pilosus
BGC0002192.3	0.80	PKS	FR901512	fungal sp. No.14919
BGC0002191.2	0.75	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001254.3	0.75	PKS	ACT-Toxin II	Alternaria alternata
BGC0000088.4	0.73	PKS	lovastatin	Aspergillus terreus
BGC0000039.3	0.72	PKS	compactin	Penicillium citrinum
BGC0001268.4	0.70	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 45000:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal) + (Me-pk)
Non-colinear ordering:: mkB + mkA

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 29615:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 11418 - 45000:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

mkB: mal

PKS_AT (544..869): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 81.5
Methoxymalonyl-CoA: 57.8
Methylmalonyl-CoA: 57.3
Isobutyryl-CoA: 28.0
Propionyl-CoA: 26.3
Benzoyl-CoA: 16.1
inactive: 9.8
2-Methylbutyryl-CoA: 9.0
Ethylmalonyl-CoA: 7.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

mkA: pk

PKS_AT (602..924): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Methylmalonyl-CoA: 62.5%; Ethylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 73.7
Methoxymalonyl-CoA: 56.1
Ethylmalonyl-CoA: 54.8
Isobutyryl-CoA: 26.8
Propionyl-CoA: 25.7
Malonyl-CoA: 25.3
2-Methylbutyryl-CoA: 22.6
fatty_acid: 19.9
trans-1,2-CPDA: 18.2
Benzoyl-CoA: 14.8
CHC-CoA: 9.6
inactive: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor