BGC0000102 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000102 (Micromonospora griseorubida)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	58,343	High	mycinamicin II	PKS

BGC0000102 - Region 1 - T1PKS

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Location: 1 - 58,343 nt. (total: 58,343 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 58,344
Label		BGC0000102

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

mycAV: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

mycCI: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

mydC: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: aminotransferase glycosyltransferase methyltransferase transferase

mycB: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

mycD: glycosyltransferase

smcogs: SMCOG1102: glycosyltransferase

mydA: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

mydD: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

mydE: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

mydG: methyltransferase

smcogs: SMCOG1248: methyltransferase

Lyases: dehydratase

mydB: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

mydI: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

mycAI: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

mycAII: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

mycAIII: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

mycAIV: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000102.5	1.00	PKS	mycinamicin II	Micromonospora griseorubida
BGC0000018.5	0.78	PKS	angolamycin	Streptomyces eurythermus
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000041.3	0.68	PKS	oronofacic acid	Pseudomonas syringae
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0000166.5	0.66	PKS	tylactone	Streptomyces fradiae
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000102.5	1.00	PKS	mycinamicin II	Micromonospora griseorubida
BGC0000018.5	0.78	PKS	angolamycin	Streptomyces eurythermus
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000041.3	0.68	PKS	oronofacic acid	Pseudomonas syringae
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0000166.5	0.66	PKS	tylactone	Streptomyces fradiae
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 58343:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk - Me-ohmal - ccmal) + (ccmal) + (Me-ccmal - Me-redmal) + (Me-ohmal) + (ccmal)
Non-colinear ordering:: mycAI + mycAII + mycAIII + mycAIV + mycAV

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

mycAI: pk - mmal - mal

PKS_AT (507..806): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 208.3
Methylmalonyl-CoA: 208.2
Methoxymalonyl-CoA: 163.7
2-Methylbutyryl-CoA: 130.6
trans-1,2-CPDA: 122.9
Propionyl-CoA: 94.7
Malonyl-CoA: 91.0
Isobutyryl-CoA: 87.0
CHC-CoA: 85.5
Benzoyl-CoA: 70.3
Acetyl-CoA: 48.8
fatty_acid: 27.7
inactive: 21.6
3-Methylbutyryl-CoA: 16.8

PKS_AT (1530..1817): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 79.2%; Malonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 168.2
Ethylmalonyl-CoA: 134.0
Methoxymalonyl-CoA: 117.9
2-Methylbutyryl-CoA: 91.5
trans-1,2-CPDA: 86.3
CHC-CoA: 82.3
Propionyl-CoA: 71.8
Malonyl-CoA: 53.3
Isobutyryl-CoA: 41.8
Benzoyl-CoA: 25.0
fatty_acid: 23.4
Acetyl-CoA: 21.4
3-Methylbutyryl-CoA: 20.1
inactive: 0.0

PKS_AT (3006..3306): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.0
inactive: 107.7
Methoxymalonyl-CoA: 68.4
Methylmalonyl-CoA: 65.6
Propionyl-CoA: 45.7
Isobutyryl-CoA: 25.3
Ethylmalonyl-CoA: 22.6
2-Methylbutyryl-CoA: 21.8
CHC-CoA: 18.7
Acetyl-CoA: 17.8
fatty_acid: 15.3
Benzoyl-CoA: 13.6
trans-1,2-CPDA: 13.1
3-Methylbutyryl-CoA: 4.9

mycAII: mal

PKS_AT (574..869): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 195.0
inactive: 92.8
Methoxymalonyl-CoA: 73.4
Methylmalonyl-CoA: 64.7
Isobutyryl-CoA: 37.3
Ethylmalonyl-CoA: 31.2
Propionyl-CoA: 30.2
Acetyl-CoA: 22.0
2-Methylbutyryl-CoA: 21.7
CHC-CoA: 19.9
Benzoyl-CoA: 19.2
trans-1,2-CPDA: 11.8
fatty_acid: 11.1
3-Methylbutyryl-CoA: 0.0

mycAIII: mmal - mmal

PKS_AT (592..892): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 79.2%; Malonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 175.9
Ethylmalonyl-CoA: 151.5
Methoxymalonyl-CoA: 129.8
CHC-CoA: 98.3
2-Methylbutyryl-CoA: 89.3
trans-1,2-CPDA: 88.4
Propionyl-CoA: 77.6
Malonyl-CoA: 58.3
Isobutyryl-CoA: 46.6
Benzoyl-CoA: 37.0
3-Methylbutyryl-CoA: 28.9
Acetyl-CoA: 28.0
fatty_acid: 25.0
inactive: 9.4

PKS_AT (2037..2337): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 79.2%; Malonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 174.0
Ethylmalonyl-CoA: 146.4
Methoxymalonyl-CoA: 128.5
CHC-CoA: 96.6
2-Methylbutyryl-CoA: 87.5
trans-1,2-CPDA: 87.4
Propionyl-CoA: 77.1
Malonyl-CoA: 63.0
Isobutyryl-CoA: 44.5
Benzoyl-CoA: 32.8
3-Methylbutyryl-CoA: 29.3
fatty_acid: 26.3
Acetyl-CoA: 21.5
inactive: 0.0

mycAIV: mmal

PKS_AT (579..880): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 79.2%; Malonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 168.4
Ethylmalonyl-CoA: 139.3
Methoxymalonyl-CoA: 124.3
CHC-CoA: 88.3
trans-1,2-CPDA: 87.1
2-Methylbutyryl-CoA: 86.9
Propionyl-CoA: 78.4
Malonyl-CoA: 61.3
Isobutyryl-CoA: 43.8
Benzoyl-CoA: 28.9
Acetyl-CoA: 28.0
fatty_acid: 25.3
3-Methylbutyryl-CoA: 22.7
inactive: 10.7

mycAV: mal

PKS_AT (570..869): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 206.8
inactive: 104.2
Methoxymalonyl-CoA: 69.3
Methylmalonyl-CoA: 60.0
Propionyl-CoA: 40.2
2-Methylbutyryl-CoA: 22.5
Ethylmalonyl-CoA: 21.8
Acetyl-CoA: 18.8
CHC-CoA: 14.3
Benzoyl-CoA: 13.9
Isobutyryl-CoA: 11.1
fatty_acid: 10.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor