BGC0000105 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000105 (Streptomyces nanchangensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	132,544	High	nanchangmycin	PKS

BGC0000105 - Region 1 - T1PKS

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Location: 1 - 132,544 nt. (total: 132,544 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 132,545
Label		BGC0000105

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

nanA8: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

nanO: monooxygenase FAD-binding

smcogs: SMCOG1246: monooxygenase FAD-binding

nanP: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: acetyltransferase acylase aminotransferase glycosyltransferase transferase

nanA1: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

nanA11: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

nanA3: acetyl-CoA acetyltransferase

smcogs: SMCOG1124: acetyl-CoA acetyltransferase

nanG1: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

nanG3: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

nanG5: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

nanG6: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

Hydrolases: hydrolase

nanE: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Lyases: dehydratase

nanG2: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

nanG4: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

nanA2: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

nanA4: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

nanA5: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

nanA6: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

nanA7: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

nanA9: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000105.5	1.00	PKS	nanchangmycin	Streptomyces nanchangensis
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002559.2	0.74	PKS	lenoremycin	Streptomyces hygroscopicus
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001160.5	0.66	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.66	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000105.5	1.00	PKS	nanchangmycin	Streptomyces nanchangensis
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002559.2	0.74	PKS	lenoremycin	Streptomyces hygroscopicus
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001160.5	0.66	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.66	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 120138:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-ccmal) + (Me-redmal) + (ccmal - Me-redmal) + (Me-ccmal - redmal) + (Me-ccmal - redmal) + (ohmal) + (Me-ohmal) + (Me-redmal) + (Me-ohmal - Me-ccmal)
Non-colinear ordering:: nanA1 + nanA2 + nanA3 + nanA4 + nanA5 + nanA6 + nanA7 + nanA11 + nanA8

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

nanA1: mal - mmal

PKS_AT (559..862): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 91.7%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 213.7
inactive: 103.1
Methoxymalonyl-CoA: 65.8
Methylmalonyl-CoA: 55.0
Propionyl-CoA: 30.3
Isobutyryl-CoA: 28.3
Ethylmalonyl-CoA: 22.3
Acetyl-CoA: 22.1
Benzoyl-CoA: 19.1
fatty_acid: 15.1
CHC-CoA: 12.6
3-Methylbutyryl-CoA: 6.1
2-Methylbutyryl-CoA: 3.1
trans-1,2-CPDA: 0.0

PKS_AT (1587..1887): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 203.4
Ethylmalonyl-CoA: 191.8
Methoxymalonyl-CoA: 159.4
2-Methylbutyryl-CoA: 150.1
trans-1,2-CPDA: 137.0
Propionyl-CoA: 116.4
Malonyl-CoA: 96.0
CHC-CoA: 93.0
Isobutyryl-CoA: 71.0
Benzoyl-CoA: 61.2
Acetyl-CoA: 47.9
fatty_acid: 46.5
3-Methylbutyryl-CoA: 32.4
inactive: 29.3

nanA2: mmal

PKS_AT (577..874): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 217.6
Ethylmalonyl-CoA: 211.6
Methoxymalonyl-CoA: 172.0
2-Methylbutyryl-CoA: 146.1
trans-1,2-CPDA: 130.5
Propionyl-CoA: 128.6
Malonyl-CoA: 107.5
CHC-CoA: 93.7
Isobutyryl-CoA: 64.4
Acetyl-CoA: 53.4
fatty_acid: 50.9
Benzoyl-CoA: 48.4
inactive: 32.8
3-Methylbutyryl-CoA: 30.5

nanA3: mal - mmal

PKS_AT (576..873): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 216.9
inactive: 113.8
Methoxymalonyl-CoA: 63.5
Methylmalonyl-CoA: 59.6
Ethylmalonyl-CoA: 31.4
Propionyl-CoA: 30.5
Isobutyryl-CoA: 28.2
Acetyl-CoA: 23.1
Benzoyl-CoA: 21.2
CHC-CoA: 18.2
2-Methylbutyryl-CoA: 12.8
fatty_acid: 8.5
trans-1,2-CPDA: 7.8
3-Methylbutyryl-CoA: 0.0

PKS_AT (2407..2707): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.1
Ethylmalonyl-CoA: 194.4
Methoxymalonyl-CoA: 165.4
2-Methylbutyryl-CoA: 157.8
trans-1,2-CPDA: 132.0
Propionyl-CoA: 117.5
CHC-CoA: 98.8
Malonyl-CoA: 88.7
Isobutyryl-CoA: 70.4
Benzoyl-CoA: 50.5
Acetyl-CoA: 38.7
3-Methylbutyryl-CoA: 37.0
inactive: 27.5
fatty_acid: 26.5

nanA4: mmal - mal

PKS_AT (598..898): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 214.5
Ethylmalonyl-CoA: 200.9
Methoxymalonyl-CoA: 168.1
2-Methylbutyryl-CoA: 149.3
trans-1,2-CPDA: 134.3
Propionyl-CoA: 107.5
CHC-CoA: 103.5
Malonyl-CoA: 102.4
Isobutyryl-CoA: 68.9
Benzoyl-CoA: 49.4
Acetyl-CoA: 45.2
fatty_acid: 29.5
inactive: 26.2
3-Methylbutyryl-CoA: 24.4

PKS_AT (2361..2655): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 171.9
inactive: 78.6
Methoxymalonyl-CoA: 62.7
Methylmalonyl-CoA: 59.2
Isobutyryl-CoA: 36.9
fatty_acid: 36.8
Propionyl-CoA: 24.3
Ethylmalonyl-CoA: 23.4
trans-1,2-CPDA: 21.1
Acetyl-CoA: 18.2
2-Methylbutyryl-CoA: 13.5
CHC-CoA: 12.3
Benzoyl-CoA: 10.7
3-Methylbutyryl-CoA: 0.0

nanA5: mmal - mal

PKS_AT (585..885): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 79.2%; Malonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 197.4
Ethylmalonyl-CoA: 181.0
Methoxymalonyl-CoA: 157.5
2-Methylbutyryl-CoA: 128.3
trans-1,2-CPDA: 121.4
Malonyl-CoA: 102.8
Propionyl-CoA: 101.9
CHC-CoA: 81.9
Isobutyryl-CoA: 81.0
Benzoyl-CoA: 63.8
Acetyl-CoA: 54.0
3-Methylbutyryl-CoA: 35.2
inactive: 29.3
fatty_acid: 23.5

PKS_AT (2355..2657): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 178.2
inactive: 67.9
Methoxymalonyl-CoA: 57.6
Methylmalonyl-CoA: 52.2
Isobutyryl-CoA: 29.4
fatty_acid: 26.6
Acetyl-CoA: 26.5
Ethylmalonyl-CoA: 23.7
Propionyl-CoA: 23.5
trans-1,2-CPDA: 18.1
2-Methylbutyryl-CoA: 15.0
CHC-CoA: 14.2
Benzoyl-CoA: 9.1
3-Methylbutyryl-CoA: 0.0

nanA6: mal

PKS_AT (565..867): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 179.1
inactive: 69.7
Methoxymalonyl-CoA: 59.6
Methylmalonyl-CoA: 53.1
Isobutyryl-CoA: 33.3
Acetyl-CoA: 27.4
fatty_acid: 26.4
Ethylmalonyl-CoA: 24.1
Propionyl-CoA: 23.3
trans-1,2-CPDA: 18.1
2-Methylbutyryl-CoA: 15.8
CHC-CoA: 14.2
Benzoyl-CoA: 9.1
3-Methylbutyryl-CoA: 0.0

nanA7: mmal

PKS_AT (568..869): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 201.8
Ethylmalonyl-CoA: 190.3
Methoxymalonyl-CoA: 163.9
2-Methylbutyryl-CoA: 143.6
trans-1,2-CPDA: 125.1
Propionyl-CoA: 109.0
CHC-CoA: 83.6
Malonyl-CoA: 83.4
Isobutyryl-CoA: 79.8
Benzoyl-CoA: 56.1
Acetyl-CoA: 43.3
fatty_acid: 37.3
3-Methylbutyryl-CoA: 32.7
inactive: 25.4

nanA11: mmal

PKS_AT (560..857): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 224.2
Ethylmalonyl-CoA: 211.8
Methoxymalonyl-CoA: 188.0
2-Methylbutyryl-CoA: 146.2
trans-1,2-CPDA: 134.1
CHC-CoA: 120.0
Malonyl-CoA: 113.6
Propionyl-CoA: 104.6
Isobutyryl-CoA: 91.2
Benzoyl-CoA: 78.7
3-Methylbutyryl-CoA: 53.3
Acetyl-CoA: 49.1
fatty_acid: 37.9
inactive: 30.5

nanA8: mmal - mmal

PKS_AT (581..875): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.4
Ethylmalonyl-CoA: 201.6
Methoxymalonyl-CoA: 169.6
2-Methylbutyryl-CoA: 161.6
trans-1,2-CPDA: 132.1
Propionyl-CoA: 124.5
Malonyl-CoA: 114.0
CHC-CoA: 106.8
Isobutyryl-CoA: 90.0
Acetyl-CoA: 66.7
Benzoyl-CoA: 64.1
3-Methylbutyryl-CoA: 44.4
inactive: 40.0
fatty_acid: 34.3

PKS_AT (2134..2428): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.4
Ethylmalonyl-CoA: 201.6
Methoxymalonyl-CoA: 169.6
2-Methylbutyryl-CoA: 161.6
trans-1,2-CPDA: 132.1
Propionyl-CoA: 124.5
Malonyl-CoA: 114.0
CHC-CoA: 106.8
Isobutyryl-CoA: 90.0
Acetyl-CoA: 66.7
Benzoyl-CoA: 64.1
3-Methylbutyryl-CoA: 44.4
inactive: 40.0
fatty_acid: 34.3

Link to PARAS substrate predictor