BGC0000126 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000126 (Streptomyces platensis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	74,342	lasalocid	Polyketide	27%

BGC0000126 - Region 1 - T1PKS

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Location: 1 - 74,342 nt. (total: 74,342 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 74,343
Label		BGC0000126

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000126.1	0.81	Polyketide	pladienolide B	Streptomyces platensis
BGC0000067.1	0.35	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001012.1	0.30	NRP, Polyketide	meridamycin	Streptomyces violaceusniger
BGC0001276.1	0.30	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.1	0.30	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001244.1	0.29	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001275.1	0.29	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001164.1	0.29	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001858.1	0.28	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000041.1	0.28	Polyketide	oronofacic acid	Pseudomonas syringae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000126.1	0.94	Polyketide	pladienolide B	Streptomyces platensis
BGC0000067.1	0.68	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001012.1	0.64	NRP, Polyketide	meridamycin	Streptomyces violaceusniger
BGC0001276.1	0.64	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.1	0.63	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001244.1	0.63	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001275.1	0.63	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001164.1	0.63	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001858.1	0.62	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000041.1	0.62	Polyketide	oronofacic acid	Pseudomonas syringae

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 74342:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - Me-ohmal - ccmal - Me-redmal) + (ccmal - Me-ccmal - Me-ohmal - ccmal) + (Me-ohmal - redmal) + (ohmal)
Non-colinear ordering:: pldAI + pldAII + pldAIII + pldAIV

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

pldAI

PKS_AT (540..838): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 215.8
Ethylmalonyl-CoA: 204.2
Methoxymalonyl-CoA: 185.1
2-Methylbutyryl-CoA: 145.8
trans-1,2-CPDA: 130.1
CHC-CoA: 116.3
Propionyl-CoA: 112.2
Malonyl-CoA: 109.6
Benzoyl-CoA: 71.7
Isobutyryl-CoA: 68.6
Acetyl-CoA: 43.7
3-Methylbutyryl-CoA: 38.6
inactive: 36.4
fatty_acid: 31.3

PKS_AT (1556..1854): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 202.6
Ethylmalonyl-CoA: 187.5
Methoxymalonyl-CoA: 171.3
2-Methylbutyryl-CoA: 144.3
trans-1,2-CPDA: 110.5
CHC-CoA: 108.5
Malonyl-CoA: 101.1
Propionyl-CoA: 95.8
Isobutyryl-CoA: 67.8
Benzoyl-CoA: 58.7
Acetyl-CoA: 45.9
inactive: 36.3
fatty_acid: 36.3
3-Methylbutyryl-CoA: 35.8

PKS_AT (3122..3422): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 91.7%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 220.3
inactive: 122.0
Methoxymalonyl-CoA: 71.3
Methylmalonyl-CoA: 66.7
Isobutyryl-CoA: 40.9
Benzoyl-CoA: 32.9
Propionyl-CoA: 31.7
Acetyl-CoA: 30.3
Ethylmalonyl-CoA: 27.1
trans-1,2-CPDA: 19.7
2-Methylbutyryl-CoA: 14.2
CHC-CoA: 11.6
fatty_acid: 11.4
3-Methylbutyryl-CoA: 0.0

PKS_AT (4907..5205): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 212.3
Ethylmalonyl-CoA: 195.9
Methoxymalonyl-CoA: 181.8
2-Methylbutyryl-CoA: 146.9
trans-1,2-CPDA: 124.0
CHC-CoA: 114.1
Propionyl-CoA: 112.6
Malonyl-CoA: 104.6
Isobutyryl-CoA: 68.1
Benzoyl-CoA: 63.6
Acetyl-CoA: 46.3
3-Methylbutyryl-CoA: 45.6
inactive: 30.8
fatty_acid: 27.4

pldAII

PKS_AT (590..892): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 91.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.4
inactive: 107.0
Methylmalonyl-CoA: 63.7
Methoxymalonyl-CoA: 62.7
Isobutyryl-CoA: 45.3
Ethylmalonyl-CoA: 34.5
Propionyl-CoA: 30.2
Benzoyl-CoA: 27.7
2-Methylbutyryl-CoA: 23.7
Acetyl-CoA: 18.3
CHC-CoA: 16.4
fatty_acid: 8.6
trans-1,2-CPDA: 7.1
3-Methylbutyryl-CoA: 6.5

PKS_AT (2384..2681): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.1
Ethylmalonyl-CoA: 193.1
Methoxymalonyl-CoA: 181.2
2-Methylbutyryl-CoA: 142.6
trans-1,2-CPDA: 124.3
CHC-CoA: 111.3
Propionyl-CoA: 110.8
Malonyl-CoA: 108.8
Isobutyryl-CoA: 67.5
Benzoyl-CoA: 63.7
Acetyl-CoA: 48.0
3-Methylbutyryl-CoA: 45.8
inactive: 32.7
fatty_acid: 27.4

PKS_AT (4204..4502): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 212.3
Ethylmalonyl-CoA: 195.9
Methoxymalonyl-CoA: 181.8
2-Methylbutyryl-CoA: 146.9
trans-1,2-CPDA: 124.0
CHC-CoA: 114.1
Propionyl-CoA: 112.6
Malonyl-CoA: 104.6
Isobutyryl-CoA: 68.1
Benzoyl-CoA: 63.6
Acetyl-CoA: 46.3
3-Methylbutyryl-CoA: 45.6
inactive: 30.8
fatty_acid: 27.4

PKS_AT (5757..6056): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 200.4
inactive: 92.1
Methoxymalonyl-CoA: 61.8
Methylmalonyl-CoA: 60.5
Isobutyryl-CoA: 43.1
Ethylmalonyl-CoA: 34.3
Propionyl-CoA: 30.8
Benzoyl-CoA: 29.3
2-Methylbutyryl-CoA: 27.9
CHC-CoA: 19.2
fatty_acid: 14.8
Acetyl-CoA: 14.7
trans-1,2-CPDA: 7.7
3-Methylbutyryl-CoA: 4.3

pldAIII

PKS_AT (569..864): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 218.5
Ethylmalonyl-CoA: 210.2
Methoxymalonyl-CoA: 183.3
2-Methylbutyryl-CoA: 168.2
trans-1,2-CPDA: 126.3
Malonyl-CoA: 120.5
Propionyl-CoA: 110.2
CHC-CoA: 110.0
Isobutyryl-CoA: 90.9
Benzoyl-CoA: 69.3
Acetyl-CoA: 48.9
3-Methylbutyryl-CoA: 34.9
fatty_acid: 30.3
inactive: 22.4

PKS_AT (2124..2424): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 70.8%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 222.1
inactive: 95.8
Methoxymalonyl-CoA: 65.5
Methylmalonyl-CoA: 55.9
Propionyl-CoA: 36.7
Ethylmalonyl-CoA: 33.5
2-Methylbutyryl-CoA: 28.9
Acetyl-CoA: 24.2
Isobutyryl-CoA: 23.9
Benzoyl-CoA: 17.9
CHC-CoA: 17.6
trans-1,2-CPDA: 11.6
fatty_acid: 11.2
3-Methylbutyryl-CoA: 0.0

pldAIV

PKS_AT (591..893): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.8
inactive: 94.9
Methoxymalonyl-CoA: 67.9
Methylmalonyl-CoA: 65.4
Isobutyryl-CoA: 35.8
Propionyl-CoA: 35.4
Benzoyl-CoA: 26.2
Ethylmalonyl-CoA: 22.1
2-Methylbutyryl-CoA: 14.8
fatty_acid: 13.1
Acetyl-CoA: 11.8
trans-1,2-CPDA: 9.4
CHC-CoA: 7.8
3-Methylbutyryl-CoA: 0.0