BGC0000143 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000143 (Streptomyces albus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	25,809	cyphomycin	Polyketide	12%

BGC0000143 - Region 1 - T1PKS

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Location: 1 - 25,809 nt. (total: 25,809 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 25,810
Label		BGC0000143

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000143.1	0.77	Polyketide	salinomycin	Streptomyces albus
BGC0001858.1	0.28	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001164.1	0.28	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001068.1	0.24	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000056.1	0.23	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0000041.1	0.23	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001909.1	0.23	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001162.1	0.23	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001235.1	0.21	NRP, Polyketide	antalid	Polyangium spumosum
BGC0001892.1	0.20	Polyketide	botcinic acid	Botrytis cinerea B05.10

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000143.1	0.92	Polyketide	salinomycin	Streptomyces albus
BGC0001858.1	0.62	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001164.1	0.61	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001068.1	0.58	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000056.1	0.57	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0000041.1	0.57	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001909.1	0.56	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001162.1	0.56	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001235.1	0.54	NRP, Polyketide	antalid	Polyangium spumosum
BGC0001892.1	0.52	Polyketide	botcinic acid	Botrytis cinerea B05.10

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 25809:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ohmal) + (ohmal - ohmal)
Non-colinear ordering:: salA + ABG02264.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

salA

PKS_AT (689..970): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 223.2
inactive: 101.4
Methoxymalonyl-CoA: 63.3
Methylmalonyl-CoA: 60.0
Propionyl-CoA: 28.8
Isobutyryl-CoA: 17.7
Acetyl-CoA: 17.4
Benzoyl-CoA: 16.9
2-Methylbutyryl-CoA: 13.4
Ethylmalonyl-CoA: 10.8
CHC-CoA: 10.6
fatty_acid: 9.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

ABG02264.1

PKS_AT (565..853): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 225.0
inactive: 94.2
Methoxymalonyl-CoA: 53.0
Methylmalonyl-CoA: 49.5
Propionyl-CoA: 20.9
Isobutyryl-CoA: 19.0
Acetyl-CoA: 18.1
Benzoyl-CoA: 18.0
2-Methylbutyryl-CoA: 9.9
Ethylmalonyl-CoA: 7.4
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2124..2406): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 218.1
inactive: 95.6
Methoxymalonyl-CoA: 63.2
Methylmalonyl-CoA: 61.9
Propionyl-CoA: 28.5
Acetyl-CoA: 19.5
Isobutyryl-CoA: 18.2
Benzoyl-CoA: 17.7
2-Methylbutyryl-CoA: 13.3
CHC-CoA: 12.8
Ethylmalonyl-CoA: 12.4
fatty_acid: 9.6
trans-1,2-CPDA: 8.9
3-Methylbutyryl-CoA: 0.0