BGC0000148: A83543A biosynthetic gene cluster from Saccharopolyspora spinosa
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Location: 1 - 80,161 nt. (total: 80,161 nt).
This entry is originally from NCBI GenBank AY007564.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000148
Short description A83543A biosynthetic gene cluster from Saccharopolyspora spinosa
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
AY007564.1
via
Compounds
  • A83543A
  • Spinosyn D
Species Saccharopolyspora spinosa [taxonomy]
References
Chemical products information
A83543A [synonyms: Spinosyn A, Lepicidin A, A 83543A] Evidence: NMR [1]
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C41H65N1O10
Chemical database entries
NPAtlas
Spinosyn D [synonyms: A 83543D, A83543D] Evidence: NMR [1]
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C42H67N1O10
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAG23282.1
 1135 - 1971 (-) probable lysR-type transcriptional regulator
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    • AAG23281.1
    		 2024 - 2791 (+) probable keto acyl reductase
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      • AAG23280.1
      • spnS
      		 3416 - 4165 (-) probable N-dimethyltransferase
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        • AAG23279.1
        • spnR
        		 4168 - 5325 (-) probable aminotransferase
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          • AAG23278.1
          • spnQ
          		 5363 - 6751 (-) probable NDP-hexose-3,4-dehydratase
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            • AAG23277.1
            • spnP
            		 7083 - 8450 (+) probable NDP-forosamyltransferase
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              • AAG23276.1
              • spnO
              		 8967 - 10427 (+) probable NDP-hexose-2,3-dehydratase
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                • AAG23275.1
                • spnN
                		 10436 - 11434 (+) probable NDP-hexose-3-ketoreductase
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                  • AAG23274.1
                  • spnM
                  		 11530 - 12492 (-) SpnM
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                    • AAG23273.1
                    • spnL
                    		 12696 - 13547 (-) methyltransferase-like protein
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                      • AAG23272.1
                      • spnK
                      		 13592 - 14785 (-) probable O-methyltransferase
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                        • AAG23271.1
                        • spnJ
                        		 14799 - 16418 (-) putative oxidoreductase
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                          • AAG23270.1
                          • spnI
                          		 16556 - 17743 (+) probable O-methyltransferase
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                            • AAG23269.1
                            • spnH
                            		 17749 - 18501 (-) probable O-methyltransferase
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                              • AAG23268.1
                              • spnG
                              		 18541 - 19713 (-) probable NDP-rhamnosyltransferase
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                                • AAG23267.1
                                • spnF
                                		 20168 - 20995 (+) methyltransferase-like protein
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                                  • AAG23264.1
                                  • spnA
                                  		 21111 - 28898 (+) polyketide synthase loading and extender module 1
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                                    • AAG23265.1
                                    • spnB
                                    		 28916 - 35374 (+) polyketide synthase extender module 2
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                                      • AAG23266.1
                                      • spnC
                                      		 35419 - 44931 (+) polyketide synthase extender modules 3-4
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                                        • AAG23263.1
                                        • spnD
                                        		 44966 - 59752 (+) polyketide synthase extender modules 5-7
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                                          • AAG23262.1
                                          • spnE
                                          		 59803 - 76569 (+) polyketide synthase extender modules 8-10
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                                            • AAG23284.1
                                            		 76932 - 77528 (+) unknown
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                                              • AAG23283.1
                                              		 77729 - 79984 (-) probable exodeoxyribonuclease V
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                                                Biosynthesis information
                                                Annotation changelog

                                                Entry version: next

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2024-04-23
                                                MIBiG v4 annotathon
                                                • (ID: XAURD3NWSTT6JKUTSXNK26RB)
                                                • (ID: U45G63MLSP33JST2JZS23R4V)
                                                • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 2

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2019-10-16
                                                Migrated from v1.4
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2019-10-16
                                                Updated compound(s) information (NPAtlas curation)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 1

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2015-06-12
                                                Submitted
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                Detailed domain annotation
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