BGC0000149: spirangien O biosynthetic gene cluster from Sorangium cellulosum
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Location: 1 - 90,501 nt. (total: 90,501 nt).
This entry is originally from NCBI GenBank AM407731.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000149
Short description spirangien O biosynthetic gene cluster from Sorangium cellulosum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
AM407731.1
1580 - 90501
via Knock-out studies
Compounds
  • spirangien O
Species Sorangium cellulosum [taxonomy]
References
Chemical products information
spirangien O Evidence:
Copy SMILES
C41H66O9
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • pseudo1188_1581
 1189 - 1581 (+)
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    • CAL58678.1
    • spiA
    		 1581 - 2372 (-) type II thioesterase
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      • CAL58679.1
      • spiB
      		 2442 - 3404 (-) O-methyltransferase
      • Tailoring
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      • CAL58680.1
      • spiC
      		 4103 - 5536 (+) cytochrome P450
      • Tailoring
      • Knock-out
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      • CAL58681.1
      • spiD
      		 5550 - 19151 (+) polyketide synthase
      • Scaffold biosynthesis
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      • CAL58682.1
      • spiE
      		 19148 - 29428 (+) polyketide synthase
      • Scaffold biosynthesis
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      • CAL58683.1
      • spiF
      		 29434 - 34386 (+) polyketide synthase
      • Scaffold biosynthesis
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      • CAL58684.1
      • spiG
      		 34751 - 50746 (+) polyketide synthase
      • Scaffold biosynthesis
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      • CAL58685.1
      • spiH
      		 50766 - 65783 (+) polyketide synthase
      • Scaffold biosynthesis
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      • CAL58686.1
      • spiI
      		 65780 - 76321 (+) polyketide synthase
      • Scaffold biosynthesis
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      • CAL58687.1
      • spiJ
      		 76314 - 87053 (+) polyketide synthase
      • Scaffold biosynthesis
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      • CAL58688.1
      • spiK
      		 87133 - 87924 (+) O-methyltransferase
      • Tailoring
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      • CAL58689.1
      • spiL
      		 88037 - 89407 (+) cytochrome P450 dependent monooxygenase
      • Tailoring
      • Knock-out
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      • CAL58690.1
      • spiZ
      		 89490 - 90128 (-) transcription factor
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        Biosynthesis information

        Biosynthetic modules

        Name
        1
        Type
        pks-modular
        Genes
        spiD
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
        Name
        2
        Type
        pks-modular
        Genes
        spiD
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
        Name
        3
        Type
        pks-modular
        Genes
        spiE
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
        Name
        4
        Type
        pks-modular
        Genes
        spiE
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
        Name
        5
        Type
        pks-modular
        Genes
        spiF
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
        Name
        6
        Type
        pks-modular
        Genes
        spiF
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
        Name
        7
        Type
        pks-modular
        Genes
        spiG
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
        Name
        8
        Type
        pks-modular
        Genes
        spiG
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
        Name
        9
        Type
        pks-modular
        Genes
        spiH
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
        Name
        10
        Type
        pks-modular
        Genes
        spiH
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
        Name
        11
        Type
        pks-modular
        Genes
        spiH
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
        Name
        12
        Type
        pks-modular
        Genes
        spiI
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
        Name
        13
        Type
        pks-modular
        Genes
        spiI
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
        Name
        14
        Type
        pks-modular
        Genes
        spiJ
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
        Name
        15
        Type
        pks-modular
        Genes
        spiJ
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
        Annotation changelog

        Entry version: 4

        Date
        Changes
        Submitters
        Reviewers
        2022-10-07
        Update chemical activity to schema version 2.11
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 3

        Date
        Changes
        Submitters
        Reviewers
        2022-09-15
        Remove leading/trailing whitespace in gene identifiers
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2022-09-15
        Removed gene annotations, including 'extra' genes, which duplicated NCBI annotations
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2022-09-15
        Updated bioactivity data
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 2

        Date
        Changes
        Submitters
        Reviewers
        2019-10-16
        Migrated from v1.4
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2019-10-16
        Updated compound(s) information (NPAtlas curation)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 1

        Date
        Changes
        Submitters
        Reviewers
        2015-06-12
        Submitted
        • (ID: 7SR74ARK6JXRBGJRGO2LUHE7)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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