BGC0000149 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000149 (Sorangium cellulosum)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	90,501	High	spirangien O	PKS:Type I

BGC0000149 - Region 1 - T1PKS

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Location: 1 - 90,501 nt. (total: 90,501 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 90,502
Label		BGC0000149

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

spiE: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

spiL: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Transferases: acylase methyltransferase

spiB: methyltransferase

smcogs: SMCOG1089: methyltransferase

spiD: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

spiH: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

spiK: methyltransferase

smcogs: SMCOG1089: methyltransferase

Hydrolases: esterase

spiA: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: synthase

spiF: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

spiG: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

spiI: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

spiJ: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000149.5	1.00	PKS	spirangien O	Sorangium cellulosum
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0000041.3	0.66	PKS	oronofacic acid	Pseudomonas syringae
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0000067.5	0.65	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000149.5	1.00	PKS	spirangien O	Sorangium cellulosum
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0000041.3	0.66	PKS	oronofacic acid	Pseudomonas syringae
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0000067.5	0.65	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 90501:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal) + (Me-ohmal - Me-ccmal) + (ccmal) + (ohmal - Me-redmal - Me-ohmal) + (Me-ohmal - ohmal - ccmal) + (ohmal - ccmal) + (ccmal - ohmal)
Non-colinear ordering:: spiD + spiE + spiF + spiG + spiH + spiI + spiJ

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

spiD: mmal - mmal - mmal

PKS_AT (684..972): mmal

ATSignature: Propionyl-CoA

Top 3 matches:: Propionyl-CoA: 100.0%; Methylmalonyl-CoA: 75.0%; Malonyl-CoA: 70.8%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 112.6
Methoxymalonyl-CoA: 92.7
Malonyl-CoA: 91.5
Ethylmalonyl-CoA: 69.3
Isobutyryl-CoA: 62.8
Propionyl-CoA: 49.5
Benzoyl-CoA: 47.7
2-Methylbutyryl-CoA: 45.8
Acetyl-CoA: 28.5
CHC-CoA: 26.8
inactive: 26.1
trans-1,2-CPDA: 18.1
fatty_acid: 16.5
3-Methylbutyryl-CoA: 3.5

PKS_AT (1135..1433): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 215.9
Ethylmalonyl-CoA: 212.4
Methoxymalonyl-CoA: 189.1
2-Methylbutyryl-CoA: 169.9
trans-1,2-CPDA: 145.4
Propionyl-CoA: 125.8
Malonyl-CoA: 111.5
CHC-CoA: 109.3
Isobutyryl-CoA: 87.4
Benzoyl-CoA: 66.2
Acetyl-CoA: 59.8
inactive: 49.7
fatty_acid: 46.7
3-Methylbutyryl-CoA: 42.3

PKS_AT (2898..3196): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.9
Ethylmalonyl-CoA: 201.6
Methoxymalonyl-CoA: 184.3
2-Methylbutyryl-CoA: 157.8
trans-1,2-CPDA: 142.1
Propionyl-CoA: 114.4
Malonyl-CoA: 109.0
CHC-CoA: 98.9
Isobutyryl-CoA: 89.3
Benzoyl-CoA: 67.4
Acetyl-CoA: 59.6
inactive: 45.2
3-Methylbutyryl-CoA: 43.6
fatty_acid: 34.2

spiE: mmal - mmal

PKS_AT (560..859): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.8
Ethylmalonyl-CoA: 205.6
Methoxymalonyl-CoA: 186.0
2-Methylbutyryl-CoA: 170.6
trans-1,2-CPDA: 134.0
Propionyl-CoA: 123.1
Malonyl-CoA: 107.7
CHC-CoA: 99.4
Isobutyryl-CoA: 89.5
Benzoyl-CoA: 68.1
Acetyl-CoA: 63.8
3-Methylbutyryl-CoA: 47.3
fatty_acid: 38.2
inactive: 33.2

PKS_AT (2121..2422): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 208.7
Ethylmalonyl-CoA: 205.0
Methoxymalonyl-CoA: 178.1
2-Methylbutyryl-CoA: 161.8
trans-1,2-CPDA: 141.9
Propionyl-CoA: 122.2
Malonyl-CoA: 109.6
CHC-CoA: 98.2
Isobutyryl-CoA: 78.4
Benzoyl-CoA: 60.6
Acetyl-CoA: 57.8
fatty_acid: 48.5
inactive: 46.0
3-Methylbutyryl-CoA: 42.1

spiF: mal

PKS_AT (565..867): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 219.1
inactive: 119.9
Methoxymalonyl-CoA: 70.9
Methylmalonyl-CoA: 55.8
Isobutyryl-CoA: 35.8
Propionyl-CoA: 26.2
Benzoyl-CoA: 18.9
Acetyl-CoA: 17.8
Ethylmalonyl-CoA: 17.1
fatty_acid: 9.3
2-Methylbutyryl-CoA: 6.0
CHC-CoA: 1.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

spiG: mal - mmal - mmal

PKS_AT (572..876): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 230.0
inactive: 125.8
Methoxymalonyl-CoA: 72.7
Methylmalonyl-CoA: 59.0
Isobutyryl-CoA: 30.8
Propionyl-CoA: 28.3
2-Methylbutyryl-CoA: 24.5
Acetyl-CoA: 20.4
Benzoyl-CoA: 18.8
Ethylmalonyl-CoA: 17.5
fatty_acid: 8.6
CHC-CoA: 7.4
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2136..2434): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.9
Ethylmalonyl-CoA: 201.6
Methoxymalonyl-CoA: 184.3
2-Methylbutyryl-CoA: 157.8
trans-1,2-CPDA: 142.1
Propionyl-CoA: 114.4
Malonyl-CoA: 109.0
CHC-CoA: 98.9
Isobutyryl-CoA: 89.3
Benzoyl-CoA: 67.4
Acetyl-CoA: 59.6
inactive: 45.2
3-Methylbutyryl-CoA: 43.6
fatty_acid: 34.2

PKS_AT (4238..4537): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.8
Ethylmalonyl-CoA: 205.6
Methoxymalonyl-CoA: 186.0
2-Methylbutyryl-CoA: 170.6
trans-1,2-CPDA: 134.0
Propionyl-CoA: 123.1
Malonyl-CoA: 107.7
CHC-CoA: 99.4
Isobutyryl-CoA: 89.5
Benzoyl-CoA: 68.1
Acetyl-CoA: 63.8
3-Methylbutyryl-CoA: 47.3
fatty_acid: 38.2
inactive: 33.2

spiH: mmal - mal - mal

PKS_AT (556..854): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 207.7
Ethylmalonyl-CoA: 202.3
Methoxymalonyl-CoA: 175.6
2-Methylbutyryl-CoA: 154.7
trans-1,2-CPDA: 123.7
Propionyl-CoA: 111.1
Malonyl-CoA: 107.8
CHC-CoA: 101.7
Isobutyryl-CoA: 82.1
Benzoyl-CoA: 60.0
Acetyl-CoA: 56.4
fatty_acid: 43.9
3-Methylbutyryl-CoA: 41.5
inactive: 37.4

PKS_AT (2109..2409): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 232.7
inactive: 125.3
Methoxymalonyl-CoA: 72.0
Methylmalonyl-CoA: 66.6
Propionyl-CoA: 46.5
Isobutyryl-CoA: 38.4
2-Methylbutyryl-CoA: 30.1
Benzoyl-CoA: 22.2
Ethylmalonyl-CoA: 19.0
Acetyl-CoA: 17.8
CHC-CoA: 12.5
fatty_acid: 10.2
trans-1,2-CPDA: 6.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (3670..3971): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 216.3
inactive: 118.6
Methoxymalonyl-CoA: 61.8
Methylmalonyl-CoA: 49.0
Propionyl-CoA: 31.7
Isobutyryl-CoA: 29.6
Benzoyl-CoA: 17.6
Acetyl-CoA: 15.1
Ethylmalonyl-CoA: 11.8
2-Methylbutyryl-CoA: 5.4
CHC-CoA: 3.0
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

spiI: mal - mal

PKS_AT (571..874): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 222.9
inactive: 122.3
Methoxymalonyl-CoA: 69.3
Methylmalonyl-CoA: 61.7
Propionyl-CoA: 35.8
Isobutyryl-CoA: 31.4
Ethylmalonyl-CoA: 26.7
Benzoyl-CoA: 18.6
2-Methylbutyryl-CoA: 18.4
Acetyl-CoA: 16.1
CHC-CoA: 9.1
fatty_acid: 8.8
trans-1,2-CPDA: 5.3
3-Methylbutyryl-CoA: 0.0

PKS_AT (2144..2445): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 216.3
inactive: 118.6
Methoxymalonyl-CoA: 61.8
Methylmalonyl-CoA: 49.0
Propionyl-CoA: 31.7
Isobutyryl-CoA: 29.6
Benzoyl-CoA: 17.6
Acetyl-CoA: 15.1
Ethylmalonyl-CoA: 11.8
2-Methylbutyryl-CoA: 5.4
CHC-CoA: 3.0
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

spiJ: mal - mal

PKS_AT (567..870): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 222.9
inactive: 122.3
Methoxymalonyl-CoA: 69.3
Methylmalonyl-CoA: 61.7
Propionyl-CoA: 35.8
Isobutyryl-CoA: 31.4
Ethylmalonyl-CoA: 26.7
Benzoyl-CoA: 18.6
2-Methylbutyryl-CoA: 18.4
Acetyl-CoA: 16.1
CHC-CoA: 9.1
fatty_acid: 8.8
trans-1,2-CPDA: 5.3
3-Methylbutyryl-CoA: 0.0

PKS_AT (2356..2658): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 202.0
inactive: 116.9
Methoxymalonyl-CoA: 64.1
Methylmalonyl-CoA: 50.6
Propionyl-CoA: 28.1
Isobutyryl-CoA: 25.1
Ethylmalonyl-CoA: 22.3
Acetyl-CoA: 19.0
Benzoyl-CoA: 15.9
2-Methylbutyryl-CoA: 14.4
CHC-CoA: 11.2
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor