BGC0000152 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000152 (Aspergillus nidulans)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	59,725	High	sterigmatocystin	PKS

BGC0000152 - Region 1 - T1PKS

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Location: 1 - 59,725 nt. (total: 59,725 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 59,726
Label		BGC0000152

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

stcB: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

stcF: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

stcL: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

stcS: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

stcU: Biaryl bond formation, Reduction

MITE: MITE0000160Biaryl bond formation, Reduction (identity: 66.50%)
smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

stcV: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: acylase sulfotransferase

stcK: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

stcT: glutathione S-transferase

smcogs: SMCOG1193: glutathione S-transferase

Hydrolases: hydrolase

stcI: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

Ligases: dehydrogenase synthase

stcA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

stcJ: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

stcU: Biaryl bond formation, Reduction

MITE: MITE0000160Biaryl bond formation, Reduction (identity: 66.50%)
smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000152.3	0.85	PKS	sterigmatocystin	Aspergillus nidulans
BGC0002175.3	0.68	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.68	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001258.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002154.2	0.67	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0000011.3	0.64	PKS	Sterigmatocystin, Aflatoxin B1, Aflatoxin B2	Aspergillus ochraceoroseus
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.62	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000152.3	1.00	PKS	sterigmatocystin	Aspergillus nidulans
BGC0002175.3	0.68	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.68	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001258.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002154.2	0.67	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.65	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001275.3	0.65	PKS	6-methylsalicyclic acid	Glarea lozoyensis

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 28582:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

stcA: mal

PKS_AT (887..1185): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 62.5%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 121.0
inactive: 48.0
Methoxymalonyl-CoA: 47.5
Methylmalonyl-CoA: 34.4
Isobutyryl-CoA: 17.7
2-Methylbutyryl-CoA: 15.4
fatty_acid: 11.8
Propionyl-CoA: 10.6
Ethylmalonyl-CoA: 10.1
CHC-CoA: 9.8
trans-1,2-CPDA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

stcK: pk

PKS_AT (1548..1733): pk

ATSignature: (unknown)

No matches above 50%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor