Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000153.1:
Cluster 1NRP / Polyketide166808

BGC0000153, stigmatellin biosynthetic gene cluster from Stigmatella aurantiaca. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Stigmatellin A
SMILES string: Copy to clipboard
Molecular formula: C30H42O7
Exact molecular mass: 515.3003 Da ([M+H]+)
Molecular activity: Antifungal

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
None
Release / cyclization type:
Other

Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Modular type I
Starter unit:
Acetyl-CoA
Thioesterase type:
None
Release / cyclization type:
Other

Modular polyketide synthases:
stiA (CAD19085.1)
Module 1
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group

stiB (CAD19086.1)
Module 2
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group

stiC (CAD19087.1)
Module 3
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group

stiD (CAD19088.1)
Module 4
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: Methylation

stiD (CAD19088.1)
Module 5
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group
Scaffold-modifying domain: Methylation

stiF (CAD19089.1)
Module 6
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group

stiG (CAD19090.1)
Module 7
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference

stiH (CAD19091.1)
Module 8
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group
Module is iterated
Evidence for iteration: Unknown

stiH (CAD19092.1)
Module 9
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Module is iterated
Evidence for iteration: Unknown

Gene cluster description

stigmatellin (BGC0000153). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank AJ421825, positions 1-66808. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:No
Contact for this cluster:Daniel Krug (HIPS)

Literature references

1. Beyer S et al. (1999) Metabolic diversity in myxobacteria: identification of the myxalamid and the stigmatellin biosynthetic gene cluster of Stigmatella aurantiaca Sg a15 and a combined polyketide-(poly)peptide gene cluster from the epothilone producing strain Sorangium cellulosum So ce90. Biochim Biophys Acta 1445(2):185-95.