BGC0000153 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000153 (Stigmatella aurantiaca Sg a15)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	66,808	ajudazol A	NRP + Polyketide:Modular type I	61%

BGC0000153 - Region 1 - T1PKS

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Location: 1 - 66,808 nt. (total: 66,808 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 66,809
Label		BGC0000153

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000153.1	0.75	NRP, Polyketide	stigmatellin	Stigmatella aurantiaca Sg a15
BGC0001273.1	0.32	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001244.1	0.30	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001276.1	0.30	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.1	0.30	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000170.1	0.29	Polyketide	yanuthone D	Aspergillus niger ATCC 1015
BGC0001858.1	0.29	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000120.1	0.28	Polyketide	patulin	Penicillium expansum
BGC0000068.1	0.26	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0000160.1	0.26	Polyketide	terreic acid	Aspergillus terreus NIH2624

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000153.1	0.91	NRP, Polyketide	stigmatellin	Stigmatella aurantiaca Sg a15
BGC0001273.1	0.65	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001244.1	0.64	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001276.1	0.64	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.1	0.64	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000170.1	0.63	Polyketide	yanuthone D	Aspergillus niger ATCC 1015
BGC0001858.1	0.62	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000120.1	0.62	Polyketide	patulin	Penicillium expansum
BGC0000068.1	0.60	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0000160.1	0.60	Polyketide	terreic acid	Aspergillus terreus NIH2624

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 66808:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (ohmal) + (OMe-Me-ohmal) + (redmal) + (Me-mal) + (ohmal) + (ccmal) + (OMe-Me-ohmal)
Non-colinear ordering:: stiJ + stiB + stiD + stiF + stiG + stiH + stiC + stiE

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

stiA

PKS_AT (606..903): pk

ATSignature: Acetyl-CoA

Top 3 matches:: Acetyl-CoA: 100.0%; CE-Malonyl-CoA: 58.3%; Methylmalonyl-CoA: 58.3%

minowa: Acetyl-CoA

Prediction, score:

Acetyl-CoA: 230.5
Methylmalonyl-CoA: 125.9
Methoxymalonyl-CoA: 104.0
Isobutyryl-CoA: 103.5
Ethylmalonyl-CoA: 100.6
Malonyl-CoA: 78.8
Propionyl-CoA: 77.7
Benzoyl-CoA: 75.4
trans-1,2-CPDA: 65.4
2-Methylbutyryl-CoA: 62.6
3-Methylbutyryl-CoA: 52.4
fatty_acid: 35.3
CHC-CoA: 34.1
inactive: 21.0

PKS_AT (1047..1343): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 79.2%; Methoxymalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 188.9
Ethylmalonyl-CoA: 159.4
Methoxymalonyl-CoA: 139.7
Isobutyryl-CoA: 113.3
Benzoyl-CoA: 106.8
2-Methylbutyryl-CoA: 99.9
Malonyl-CoA: 97.6
trans-1,2-CPDA: 92.8
Propionyl-CoA: 86.2
CHC-CoA: 73.4
Acetyl-CoA: 69.3
3-Methylbutyryl-CoA: 52.4
fatty_acid: 42.1
inactive: 28.8

stiB

PKS_AT (563..856): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 216.3
inactive: 162.9
Methylmalonyl-CoA: 83.0
Methoxymalonyl-CoA: 82.4
Propionyl-CoA: 63.2
Isobutyryl-CoA: 52.2
2-Methylbutyryl-CoA: 47.6
Ethylmalonyl-CoA: 45.5
Acetyl-CoA: 40.2
Benzoyl-CoA: 39.5
CHC-CoA: 29.8
trans-1,2-CPDA: 24.0
fatty_acid: 22.4
3-Methylbutyryl-CoA: 19.3

stiC

PKS_AT (557..853): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 200.5
inactive: 146.7
Methoxymalonyl-CoA: 61.5
Methylmalonyl-CoA: 56.4
Isobutyryl-CoA: 39.4
Propionyl-CoA: 37.6
Acetyl-CoA: 32.2
Benzoyl-CoA: 27.2
CHC-CoA: 23.1
2-Methylbutyryl-CoA: 19.9
Ethylmalonyl-CoA: 18.8
trans-1,2-CPDA: 18.4
3-Methylbutyryl-CoA: 13.9
fatty_acid: 12.9

stiD

PKS_AT (581..878): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 83.3%; Malonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 180.8
Ethylmalonyl-CoA: 169.0
Methoxymalonyl-CoA: 139.5
Malonyl-CoA: 108.3
2-Methylbutyryl-CoA: 93.3
Propionyl-CoA: 88.6
Isobutyryl-CoA: 87.8
Benzoyl-CoA: 77.9
trans-1,2-CPDA: 76.8
CHC-CoA: 70.3
Acetyl-CoA: 63.3
fatty_acid: 52.4
3-Methylbutyryl-CoA: 31.4
inactive: 27.9

stiE

PKS_AT (566..862): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Ethylmalonyl-CoA: 83.3%; Malonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 190.2
Ethylmalonyl-CoA: 172.2
Methoxymalonyl-CoA: 152.8
Isobutyryl-CoA: 124.5
Benzoyl-CoA: 109.7
Malonyl-CoA: 104.3
trans-1,2-CPDA: 99.0
2-Methylbutyryl-CoA: 98.7
Acetyl-CoA: 80.1
CHC-CoA: 79.7
Propionyl-CoA: 75.3
3-Methylbutyryl-CoA: 48.3
inactive: 45.0
fatty_acid: 38.8

stiF

PKS_AT (558..851): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 91.7%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 200.5
inactive: 156.1
Methylmalonyl-CoA: 59.5
Methoxymalonyl-CoA: 59.3
Isobutyryl-CoA: 40.7
Propionyl-CoA: 39.2
Benzoyl-CoA: 33.1
Acetyl-CoA: 20.4
Ethylmalonyl-CoA: 18.2
2-Methylbutyryl-CoA: 17.4
trans-1,2-CPDA: 16.8
CHC-CoA: 14.6
fatty_acid: 12.3
3-Methylbutyryl-CoA: 10.1

stiG

PKS_AT (578..875): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Ethylmalonyl-CoA: 83.3%; Malonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 185.2
Ethylmalonyl-CoA: 163.1
Methoxymalonyl-CoA: 145.5
Isobutyryl-CoA: 118.8
Malonyl-CoA: 106.3
trans-1,2-CPDA: 106.1
Benzoyl-CoA: 101.7
2-Methylbutyryl-CoA: 89.0
Propionyl-CoA: 74.8
Acetyl-CoA: 71.0
CHC-CoA: 68.5
3-Methylbutyryl-CoA: 53.2
fatty_acid: 33.5
inactive: 26.8

stiH

PKS_AT (570..867): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 91.7%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 205.0
inactive: 155.2
Methoxymalonyl-CoA: 73.0
Methylmalonyl-CoA: 72.0
Propionyl-CoA: 58.5
2-Methylbutyryl-CoA: 49.8
Ethylmalonyl-CoA: 49.6
Isobutyryl-CoA: 46.1
Benzoyl-CoA: 42.1
CHC-CoA: 29.0
fatty_acid: 28.5
Acetyl-CoA: 26.5
trans-1,2-CPDA: 22.1
3-Methylbutyryl-CoA: 10.5

stiJ

PKS_AT (565..861): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 91.7%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 200.0
inactive: 156.5
Methoxymalonyl-CoA: 74.4
Methylmalonyl-CoA: 70.0
Propionyl-CoA: 67.7
2-Methylbutyryl-CoA: 49.6
Ethylmalonyl-CoA: 41.5
Isobutyryl-CoA: 38.3
Benzoyl-CoA: 37.6
CHC-CoA: 32.4
trans-1,2-CPDA: 31.5
Acetyl-CoA: 21.5
fatty_acid: 19.2
3-Methylbutyryl-CoA: 11.1