BGC0000154: stipitatic acid biosynthetic gene cluster from Talaromyces stipitatus ATCC 10500
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Location: 1,805,625 - 1,837,759 nt. (total: 32,135 nt).
This entry is originally from NCBI GenBank EQ962655.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
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General
Compounds
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Biosynthesis
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NRPS/PKS domains
KnownClusterBlast
Modifications
General information about the BGC
MIBiG accession BGC0000154
Short description stipitatic acid biosynthetic gene cluster from Talaromyces stipitatus ATCC 10500
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Iterative type I)
Loci
EQ962655.1
1805625 - 1837759
via Knock-out studies
Compounds
  • stipitatic acid
Species Talaromyces stipitatus ATCC 10500 [taxonomy]
References
Chemical products information
stipitatic acid Evidence:
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C8H6O5
Chemical database entries
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • TSTA_117720
  • EED17997.1
 1805891 - 1806943 (-) Decarboxylase
  • Tailoring
  • Knock-out
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  • TSTA_117730_rename1
  • EED17999.1
 1808583 - 1810016 (-) benzoate 4-monooxygenase cytochrome P450, putative
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    • TSTA_117730
    • EED17998.1
    		 1808583 - 1810480 (-) P450
    • Tailoring
    • Knock-out
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    • TSTA_117740
    • EED18000.1
    		 1811404 - 1812826 (-) FAD oxygenase
    • Tailoring
    • Knock-out
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    • TSTA_117750
    • EED18001.1
    		 1813486 - 1821545 (+) NR-PKS
    • Scaffold biosynthesis
    • Knock-out
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    • TSTA_117760_rename1
    • EED18003.1
    		 1821999 - 1822589 (-) dienelactone hydrolase, putative
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      • TSTA_117760
      • EED18002.1
      		 1821999 - 1822878 (-) Hydrolase
      • Tailoring
      • Knock-out
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      • TSTA_117770
      • EED18004.1
      		 1823515 - 1825170 (+) conserved hypothetical protein
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        • TSTA_117780
        • EED18005.1
        		 1825779 - 1826758 (-) Hydrolase
        • Tailoring
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        • TSTA_117790
        • EED18006.1
        		 1827468 - 1829056 (+) NAD oxidase
        • Tailoring
        • Knock-out
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        • TSTA_117800
        • EED18007.1
        		 1829681 - 1830851 (-) non-heme iron oxygenase
        • Tailoring
        • Knock-out
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        • TSTA_117810_rename1
        • EED18008.1
        		 1831612 - 1833588 (-) conserved hypothetical protein
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          • TSTA_117810
          • EED18009.1
          		 1831612 - 1833588 (-) conserved hypothetical protein
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            • TSTA_117820
            • EED18010.1
            		 1836019 - 1836925 (+) NAD oxidase
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            • Knock-out
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            Biosynthesis information
            Annotation changelog

            Entry version: 3

            Date
            Changes
            Submitters
            Reviewers
            2022-10-07
            Update chemical activity to schema version 2.11
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 2

            Date
            Changes
            Submitters
            Reviewers
            2019-10-16
            Migrated from v1.4
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2019-10-16
            Updated compound(s) information (NPAtlas curation)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 1

            Date
            Changes
            Submitters
            Reviewers
            2015-06-12
            Submitted
            • (ID: 3XTF2R3BHL5LPPSMGJ2QHJQC)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            Detailed domain annotation
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            Modifications to original record
            • renamed CDS with name TSTA_117730 at join{[1809737:1810016](-), [1809460:1809687](-), [1808961:1809400](-), [1808810:1808900](-), [1808582:1808699](-)} to TSTA_117730_rename1 to avoid duplicates
            • renamed CDS with name TSTA_117760 at join{[1822412:1822589](-), [1821998:1822364](-)} to TSTA_117760_rename1 to avoid duplicates
            • renamed CDS with name TSTA_117810 at join{[1833359:1833588](-), [1832967:1833244](-), [1832390:1832886](-), [1831611:1832334](-)} to TSTA_117810_rename1 to avoid duplicates