BGC0000154: stipitatic acid biosynthetic gene cluster from Talaromyces stipitatus ATCC 10500
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Location: 1,805,625 - 1,837,759 nt. (total: 32,135 nt).
This entry is originally from NCBI GenBank EQ962655.1, but has been modified (see Modifications tab for details).

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General
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Polyketide
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NRPS/PKS domains
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Modifications
General information about the BGC
MIBiG accession BGC0000154
Short description stipitatic acid biosynthetic gene cluster from Talaromyces stipitatus ATCC 10500
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: EQ962655.1
Compounds
  • stipitatic acid
Species Talaromyces stipitatus ATCC 10500 [taxonomy]
References
Chemical products information
stipitatic acid
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C8H6O5
Chemical database entries
PubCHEM
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List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • TSTA_117720
  • EED17997.1
 1805891 - 1806943 (-) Decarboxylase
  • Tailoring (Decarboxylation)
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  • TSTA_117730_rename1
  • EED17999.1
 1808583 - 1810016 (-) benzoate 4-monooxygenase cytochrome P450, putative
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  • TSTA_117730
  • EED17998.1
 1808583 - 1810480 (-) P450
  • Tailoring (Oxidation)
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  • TSTA_117740
  • EED18000.1
 1811404 - 1812826 (-) FAD oxygenase
  • Tailoring (Oxidation)
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  • TSTA_117750
  • EED18001.1
 1813486 - 1821545 (+) NR-PKS
  • Scaffold biosynthesis
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  • TSTA_117760_rename1
  • EED18003.1
 1821999 - 1822589 (-) dienelactone hydrolase, putative
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  • TSTA_117760
  • EED18002.1
 1821999 - 1822878 (-) Hydrolase
  • Tailoring (Hydrolysis)
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  • TSTA_117770
  • EED18004.1
 1823515 - 1825170 (+) conserved hypothetical protein
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  • TSTA_117780
  • EED18005.1
 1825779 - 1826758 (-) Hydrolase
  • Tailoring (Hydrolysis)
Sequence-based prediction
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  • TSTA_117790
  • EED18006.1
 1827468 - 1829056 (+) NAD oxidase
  • Tailoring (Oxidation)
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  • TSTA_117800
  • EED18007.1
 1829681 - 1830851 (-) non-heme iron oxygenase
  • Tailoring (Oxidation)
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  • TSTA_117810_rename1
  • EED18008.1
 1831612 - 1833588 (-) conserved hypothetical protein
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  • TSTA_117810
  • EED18009.1
 1831612 - 1833588 (-) conserved hypothetical protein
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  • TSTA_117820
  • EED18010.1
 1836019 - 1836925 (+) NAD oxidase
  • Tailoring (Oxidation)
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? yes
Release type
  • Reductive release
Polyketide-synthases
Genes Properties Modules
TSTA_117750 Synthase subclass: Iterative type I
Iterative PKS type: Non-reducing, C2-C7 first
Iteration counts: 3
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 3XTF2R3BHL5LPPSMGJ2QHJQC, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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Modifications to original record
  • renamed CDS with name TSTA_117730 at join{[1809737:1810016](-), [1809460:1809687](-), [1808961:1809400](-), [1808810:1808900](-), [1808582:1808699](-)} to TSTA_117730_rename1 to avoid duplicates
  • renamed CDS with name TSTA_117760 at join{[1822412:1822589](-), [1821998:1822364](-)} to TSTA_117760_rename1 to avoid duplicates
  • renamed CDS with name TSTA_117810 at join{[1833359:1833588](-), [1832967:1833244](-), [1832390:1832886](-), [1831611:1832334](-)} to TSTA_117810_rename1 to avoid duplicates