Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000154.1:
Cluster 1Polyketide132135

BGC0000154, stipitatic acid biosynthetic gene cluster from Talaromyces stipitatus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: stipitatic acid
ChemSpider ID: 19955692
SMILES string: Copy to clipboard
Molecular formula:
Average molecular mass: Da
Molecular activity: Other
Molecular target: Unknown

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Iterative type I
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
TSTA_117750
Iterative PKS subtype:
Non-reducing
Number of iterations:
3
C2-C7 first
Thioesterase type:
Unknown
Release / cyclization type:
Reductive release

Gene cluster description

stipitatic acid (BGC0000154). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank EQ962655, positions 1790000-1845000. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Russell Cox (Leibniz Universitaet Hannover)

Literature references

1. Davison J et al. (2012) Genetic, molecular, and biochemical basis of fungal tropolone biosynthesis. Proc Natl Acad Sci U S A 109(20):7642-7. doi:
2. Cox RJ, Al-Fahad A. (2013) Chemical mechanisms involved during the biosynthesis of tropolones. Curr Opin Chem Biol 17(4):532-6. doi: 10.1016/j.cbpa.2013.06.029. Epub
3. al Fahad A et al. (2014) The biosynthesis and catabolism of the maleic anhydride moiety of stipitatonic acid. Angew Chem Int Ed Engl 53(29):7519-23. doi: 10.1002/anie.201403450.