BGC0000154 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000154 (Talaromyces stipitatus ATCC 10500)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	32,135	ankaflavin / monascin / rubropunctatine / monascorubrin	Polyketide:Iterative type I	12%

BGC0000154 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 32,135 nt. (total: 32,135 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 32,136
Label		BGC0000154

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000154.1	1.00	Polyketide	stipitatic acid	Talaromyces stipitatus ATCC 10500
BGC0000099.1	0.39	Polyketide	monascorubrin	Talaromyces marneffei
BGC0000013.1	0.32	Polyketide	alternariol	Aspergillus nidulans FGSC A4
BGC0000161.1	0.29	Polyketide	isoterrein	Aspergillus terreus NIH2624
BGC0001280.1	0.28	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.28	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0000152.1	0.28	Polyketide	sterigmatocystin	Aspergillus nidulans
BGC0001068.1	0.27	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000168.1	0.26	Polyketide	viridicatumtoxin, previridicatumtoxin, 5-hydroxyanthrotainin, 8-O-desmethylanthrotainin	Penicillium aethiopicum
BGC0000046.1	0.26	Polyketide	depudecin	Alternaria brassicicola

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000154.1	1.00	Polyketide	stipitatic acid	Talaromyces stipitatus ATCC 10500
BGC0000099.1	0.71	Polyketide	monascorubrin	Talaromyces marneffei
BGC0000013.1	0.65	Polyketide	alternariol	Aspergillus nidulans FGSC A4
BGC0000161.1	0.62	Polyketide	isoterrein	Aspergillus terreus NIH2624
BGC0001280.1	0.62	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.62	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0000152.1	0.61	Polyketide	sterigmatocystin	Aspergillus nidulans
BGC0001068.1	0.61	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000168.1	0.59	Polyketide	viridicatumtoxin, previridicatumtoxin, 5-hydroxyanthrotainin, 8-O-desmethylanthrotainin	Penicillium aethiopicum
BGC0000046.1	0.59	Polyketide	depudecin	Alternaria brassicicola

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 32135:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

TSTA_117750

PKS_AT (901..1198): mal

ATSignature: Ethylmalonyl-CoA, Malonyl-CoA, Methylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 58.3%; Malonyl-CoA: 58.3%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 58.2
Methoxymalonyl-CoA: 57.6
Methylmalonyl-CoA: 52.2
inactive: 43.4
Ethylmalonyl-CoA: 29.2
Propionyl-CoA: 28.4
fatty_acid: 25.8
CHC-CoA: 24.3
Benzoyl-CoA: 22.5
trans-1,2-CPDA: 21.8
2-Methylbutyryl-CoA: 20.6
3-Methylbutyryl-CoA: 13.4
Isobutyryl-CoA: 12.8
Acetyl-CoA: 12.7