BGC0000159: tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus
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Location: 1 - 94,050 nt. (total: 94,050 nt).
This entry is originally from NCBI GenBank EF990140.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000159
Short description tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
EF990140.1
via Knock-out studies
Compounds
  • tautomycin
Species Streptomyces spiroverticillatus [taxonomy]
References
Chemical products information
tautomycin Evidence:
Copy SMILES
C41H66O13
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABW96537.1
 347 - 1027 (-) conserved hypothetical protein
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    • ABW96536.1
    		 1065 - 1427 (-) hypothetical protein
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      • ABW96535.1
      		 1316 - 1942 (-) hypothetical protein
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        • ABW96534.1
        		 2500 - 3213 (-) putative dehydrogenase
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          • ABW96533.1
          		 3409 - 5178 (+) putative MOSC ferredoxin--oxidoreductase
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            • ABW96532.1
            		 5384 - 6079 (+) hypothetical protein
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              • ABW96538.1
              • ttmF
              		 7322 - 8611 (+) putative regulatory protein
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                • ABW96539.1
                • ttmG
                		 8676 - 9206 (-) putative decarboxylase
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                  • ABW96540.1
                  • ttmH
                  		 9369 - 26681 (-) type I modular polyketide synthase
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                    • ABW96541.1
                    • ttmI
                    		 26694 - 43826 (-) type I modular polyketide synthase
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                      • ABW96542.1
                      • ttmJ
                      		 43846 - 76329 (-) type I modular polyketide synthase
                      • Scaffold biosynthesis
                      • Knock-out
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                      • ABW96543.1
                      • ttmK
                      		 76705 - 78075 (+) type B carboxylesterase
                      • Scaffold biosynthesis
                      • Knock-out
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                      • ABW96544.1
                      • ttmL
                      		 78092 - 78664 (-) conserved hypothetical protein
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                        • ABW96557.1
                        • ttmE
                        		 79404 - 80489 (-) phosphatase, methoxymalonyl-ACP biosynthesis protein
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                          • ABW96553.1
                          • ttmA
                          		 80486 - 81607 (-) acyl-CoA dehydrogenase
                          • Precursor biosynthesis
                          • Knock-out
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                          • ABW96556.1
                          • ttmD
                          		 81604 - 81858 (-) acyl-carrier protein
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                            • ABW96554.1
                            • ttmB
                            		 81855 - 82724 (-) 3-hydroxyacyl-CoA dehydrogenase
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                              • ABW96555.1
                              • ttmC
                              		 82892 - 83548 (-) O-methyl transferase
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                                • ABW96545.1
                                • ttmM
                                		 83662 - 84723 (-) hydroxylase
                                • Tailoring
                                • Knock-out
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                                • ABW96546.1
                                • ttmN
                                		 84758 - 85864 (-) conserved hypothetical protein
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                                  • ABW96547.1
                                  • ttmO
                                  		 85861 - 86805 (-) probable citrate lyase beta subunit
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                                    • ABW96548.1
                                    • ttmP
                                    		 86802 - 88025 (-) acyl-CoA transferases/carnitine
                                    • Scaffold biosynthesis
                                    • Knock-out
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                                    • ABW96549.1
                                    • ttmQ
                                    		 88381 - 89436 (+) predicted transcriptional regulator protein
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                                      • ABW96550.1
                                      • ttmR
                                      		 89450 - 90853 (-) MmgE/PrpD family protein
                                      • Scaffold biosynthesis
                                      • Knock-out
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                                      • ABW96551.1
                                      • ttmS
                                      		 90850 - 91674 (-) cyclase
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                                        • ABW96552.1
                                        • ttmT
                                        		 91736 - 92509 (-) probable thioesterase
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                                          • ABW96529.1
                                          		 92506 - 92778 (-) hypothetical protein
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                                            • ABW96530.1
                                            		 92966 - 93553 (+) hypothetical protein
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                                              • ABW96531.1
                                              		 93572 - 93961 (+) hypothetical protein
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                                                Biosynthesis information

                                                Biosynthetic modules

                                                Name
                                                0
                                                Type
                                                pks-modular-starter
                                                Genes
                                                ttmJ
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, carrier (ACP)
                                                Name
                                                1
                                                Type
                                                pks-modular
                                                Genes
                                                ttmJ
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                Name
                                                2
                                                Type
                                                pks-modular
                                                Genes
                                                ttmJ
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                Name
                                                3
                                                Type
                                                pks-modular
                                                Genes
                                                ttmJ
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                Name
                                                4
                                                Type
                                                pks-modular
                                                Genes
                                                ttmJ
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                Name
                                                5
                                                Type
                                                pks-modular
                                                Genes
                                                ttmJ
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                                                Name
                                                6
                                                Type
                                                pks-modular
                                                Genes
                                                ttmJ
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                Name
                                                7
                                                Type
                                                pks-modular
                                                Genes
                                                ttmI
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                                                Name
                                                8
                                                Type
                                                pks-modular
                                                Genes
                                                ttmI
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                Name
                                                9
                                                Type
                                                pks-modular
                                                Genes
                                                ttmI
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                                                Name
                                                10
                                                Type
                                                pks-modular
                                                Genes
                                                ttmH
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                Name
                                                11
                                                Type
                                                pks-modular
                                                Genes
                                                ttmH
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                                                Name
                                                12
                                                Type
                                                pks-modular
                                                Genes
                                                ttmH
                                                Substrates
                                                Integrated Monomers
                                                Domains
                                                acyltransferase, ketosynthase, acyltransferase, thioesterase, carrier (ACP)
                                                Annotation changelog

                                                Entry version: 4

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-10-07
                                                Update chemical activity to schema version 2.11
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 3

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-09-15
                                                Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2022-09-15
                                                Corrected gene identifiers
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2022-09-15
                                                Updated bioactivity data
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 2

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2019-10-16
                                                Migrated from v1.4
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 1

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2015-06-12
                                                Submitted
                                                • (ID: E2T2HCM4X7QXVS4LL4JVBPPK)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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