BGC0000159 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000159 (Streptomyces spiroverticillatus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	94,050	tautomycetin	Polyketide:Modular type I	61%

BGC0000159 - Region 1 - T1PKS

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Location: 1 - 94,050 nt. (total: 94,050 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 94,051
Label		BGC0000159

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000159.1	0.75	Polyketide	tautomycin	Streptomyces spiroverticillatus
BGC0000067.1	0.30	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000041.1	0.30	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001275.1	0.29	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.1	0.29	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001244.1	0.28	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001504.1	0.27	Polyketide	amycomicin	Amycolatopsis sp. AA4
BGC0000228.1	0.27	Polyketide	granaticin	Streptomyces violaceoruber
BGC0000068.1	0.26	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0001062.1	0.26	Polyketide	TLN-05220	Micromonospora echinospora subsp. challisensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000159.1	0.91	Polyketide	tautomycin	Streptomyces spiroverticillatus
BGC0000067.1	0.64	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000041.1	0.63	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001275.1	0.62	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.1	0.62	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001244.1	0.62	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001504.1	0.61	Polyketide	amycomicin	Amycolatopsis sp. AA4
BGC0000228.1	0.60	Polyketide	granaticin	Streptomyces violaceoruber
BGC0000068.1	0.60	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0001062.1	0.59	Polyketide	TLN-05220	Micromonospora echinospora subsp. challisensis

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 94050:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - pk - ohmal - Me-ccmal - ccmal - Me-redmal - Me-ohmal) + (redmal - ohmal - Me-redmal) + (ccmal - Me-redmal - ccmal)
Non-colinear ordering:: ttmJ + ttmI + ttmH

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ttmH

PKS_AT (570..858): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 214.1
inactive: 92.8
Methoxymalonyl-CoA: 62.8
Methylmalonyl-CoA: 55.0
Isobutyryl-CoA: 50.7
Propionyl-CoA: 37.9
fatty_acid: 23.1
2-Methylbutyryl-CoA: 22.8
Ethylmalonyl-CoA: 22.5
Acetyl-CoA: 20.5
Benzoyl-CoA: 20.3
CHC-CoA: 17.7
trans-1,2-CPDA: 15.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (2282..2576): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.2
Ethylmalonyl-CoA: 184.7
Methoxymalonyl-CoA: 164.9
2-Methylbutyryl-CoA: 138.6
Propionyl-CoA: 114.8
trans-1,2-CPDA: 112.8
Malonyl-CoA: 102.8
CHC-CoA: 99.9
Isobutyryl-CoA: 74.6
Benzoyl-CoA: 71.0
Acetyl-CoA: 53.5
inactive: 40.9
fatty_acid: 34.9
3-Methylbutyryl-CoA: 32.7

PKS_AT (4339..4629): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 66.7%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.6
inactive: 84.4
Methoxymalonyl-CoA: 66.2
Methylmalonyl-CoA: 51.9
Propionyl-CoA: 35.6
Isobutyryl-CoA: 33.8
Acetyl-CoA: 18.1
Benzoyl-CoA: 17.8
trans-1,2-CPDA: 15.3
fatty_acid: 15.2
CHC-CoA: 11.9
2-Methylbutyryl-CoA: 11.8
3-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -4.5

ttmI

PKS_AT (571..861): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 206.7
inactive: 86.7
Methoxymalonyl-CoA: 60.5
Methylmalonyl-CoA: 52.6
Propionyl-CoA: 42.4
Isobutyryl-CoA: 26.6
trans-1,2-CPDA: 23.9
2-Methylbutyryl-CoA: 23.5
Acetyl-CoA: 23.3
Ethylmalonyl-CoA: 20.9
Benzoyl-CoA: 19.8
fatty_acid: 19.5
CHC-CoA: 15.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2610..2898): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 213.9
inactive: 80.4
Methoxymalonyl-CoA: 64.1
Methylmalonyl-CoA: 51.2
Isobutyryl-CoA: 34.3
Propionyl-CoA: 33.3
Acetyl-CoA: 25.0
Benzoyl-CoA: 23.2
2-Methylbutyryl-CoA: 17.8
fatty_acid: 14.8
Ethylmalonyl-CoA: 13.3
CHC-CoA: 12.4
trans-1,2-CPDA: 12.2
3-Methylbutyryl-CoA: 0.0

PKS_AT (4128..4422): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 212.0
Ethylmalonyl-CoA: 204.6
Methoxymalonyl-CoA: 170.9
2-Methylbutyryl-CoA: 151.8
Propionyl-CoA: 127.7
trans-1,2-CPDA: 126.6
CHC-CoA: 114.5
Malonyl-CoA: 103.6
Isobutyryl-CoA: 70.6
Benzoyl-CoA: 70.0
Acetyl-CoA: 54.0
fatty_acid: 44.4
inactive: 30.8
3-Methylbutyryl-CoA: 29.4

ttmJ

PKS_AT (104..400): mmal

ATSignature: Isobutyryl-CoA

Top 3 matches:: Isobutyryl-CoA: 91.7%; Methylmalonyl-CoA: 79.2%; 2-Methylbutyryl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 163.4
Ethylmalonyl-CoA: 161.4
2-Methylbutyryl-CoA: 150.8
Methoxymalonyl-CoA: 129.0
Propionyl-CoA: 118.4
Malonyl-CoA: 97.9
trans-1,2-CPDA: 97.0
CHC-CoA: 95.5
Isobutyryl-CoA: 59.7
inactive: 39.7
Benzoyl-CoA: 37.2
Acetyl-CoA: 23.8
3-Methylbutyryl-CoA: 21.6
fatty_acid: 17.9

PKS_AT (1093..1393): pk

ATSignature: Methoxymalonyl-CoA

Top 3 matches:: Methoxymalonyl-CoA: 100.0%; Ethylmalonyl-CoA: 91.7%; Methylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 188.4
Ethylmalonyl-CoA: 187.9
Methoxymalonyl-CoA: 187.7
2-Methylbutyryl-CoA: 127.4
trans-1,2-CPDA: 104.7
CHC-CoA: 104.0
Propionyl-CoA: 101.1
Malonyl-CoA: 99.8
Isobutyryl-CoA: 66.2
Benzoyl-CoA: 51.6
Acetyl-CoA: 50.0
3-Methylbutyryl-CoA: 35.0
fatty_acid: 34.1
inactive: 19.1

PKS_AT (2815..3104): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 225.2
inactive: 91.5
Methoxymalonyl-CoA: 67.8
Methylmalonyl-CoA: 65.7
Propionyl-CoA: 42.2
Isobutyryl-CoA: 30.4
Benzoyl-CoA: 22.0
Ethylmalonyl-CoA: 20.5
Acetyl-CoA: 20.3
2-Methylbutyryl-CoA: 19.2
CHC-CoA: 17.6
trans-1,2-CPDA: 16.2
fatty_acid: 14.3
3-Methylbutyryl-CoA: 0.0

PKS_AT (4330..4622): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.2
Ethylmalonyl-CoA: 187.1
Methoxymalonyl-CoA: 168.3
2-Methylbutyryl-CoA: 153.0
Propionyl-CoA: 123.3
trans-1,2-CPDA: 113.5
CHC-CoA: 103.7
Malonyl-CoA: 98.6
Isobutyryl-CoA: 79.1
Benzoyl-CoA: 58.7
Acetyl-CoA: 55.1
inactive: 40.3
fatty_acid: 32.8
3-Methylbutyryl-CoA: 24.8

PKS_AT (6024..6314): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 203.6
inactive: 95.0
Methoxymalonyl-CoA: 66.5
Methylmalonyl-CoA: 55.3
Propionyl-CoA: 40.5
Isobutyryl-CoA: 33.5
Ethylmalonyl-CoA: 25.3
fatty_acid: 24.7
2-Methylbutyryl-CoA: 23.8
Acetyl-CoA: 21.1
Benzoyl-CoA: 20.3
CHC-CoA: 16.7
trans-1,2-CPDA: 14.4
3-Methylbutyryl-CoA: 0.0

PKS_AT (7744..8038): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 206.9
Ethylmalonyl-CoA: 200.4
Methoxymalonyl-CoA: 174.1
2-Methylbutyryl-CoA: 148.3
Propionyl-CoA: 123.5
trans-1,2-CPDA: 121.2
CHC-CoA: 113.9
Malonyl-CoA: 95.6
Isobutyryl-CoA: 78.7
Benzoyl-CoA: 76.2
Acetyl-CoA: 60.7
inactive: 38.9
3-Methylbutyryl-CoA: 38.9
fatty_acid: 38.7

PKS_AT (9816..10110): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 206.7
Ethylmalonyl-CoA: 198.2
Methoxymalonyl-CoA: 174.7
2-Methylbutyryl-CoA: 146.5
Propionyl-CoA: 122.1
trans-1,2-CPDA: 120.6
CHC-CoA: 114.8
Malonyl-CoA: 96.2
Isobutyryl-CoA: 77.0
Benzoyl-CoA: 76.2
Acetyl-CoA: 58.7
fatty_acid: 39.1
inactive: 36.5
3-Methylbutyryl-CoA: 36.4