BGC0000163: tetronasin biosynthetic gene cluster from Streptomyces longisporoflavus
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Location: 1 - 169,690 nt. (total: 169,690 nt).
This entry is originally from NCBI GenBank FJ462704.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000163
Short description tetronasin biosynthetic gene cluster from Streptomyces longisporoflavus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
FJ462704.1
via
Compounds
  • tetronasin
Species Streptomyces longisporoflavus [taxonomy]
References
Chemical products information
tetronasin Evidence:
Copy SMILES
C35H54O8
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACR50750.1
 2 - 910 (+) putative ABC transporter permease protein
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    • ACR50751.1
    		 1020 - 1778 (+) putative ABC transporter permease protein
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      • ACR50752.1
      		 1838 - 3256 (-) conserved hypothetical protein
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        • ACR50753.1
        		 3427 - 4326 (-) putative sugar kinase
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          • ACR50754.1
          		 4383 - 5339 (-) zinc-binding dehydrogenase
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            • ACR50755.1
            		 5369 - 6286 (-) integral membrane sugar transport protein
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              • ACR50756.1
              		 6283 - 7269 (-) putative ABC transporter permease protein
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                • ACR50757.1
                		 7266 - 8585 (-) putative multiple sugar ABC transporter solute-binding protein
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                  • ACR50758.1
                  		 8767 - 9528 (-) DeoR family transcriptional regulator
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                    • ACR50759.1
                    		 10058 - 11776 (-) putative secreted protein
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                      • ACR50760.1
                      		 11993 - 13090 (-) hypothetical protein
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                        • ACR50761.1
                        		 13457 - 14896 (+) 6-phosphogluconate 1-dehydrogenase
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                          • ACR50762.1
                          		 15322 - 15675 (-) conserved hypothetical protein
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                            • ACR50763.1
                            		 15861 - 18077 (-) periplasmic beta-glucosidase
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                              • ACR50764.1
                              		 18327 - 18683 (-) hypothetical protein
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                                • ACR50765.1
                                		 18798 - 19616 (+) hypothetical protein
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                                  • ACR50766.1
                                  		 19520 - 20401 (-) putative phosphoesterase
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                                    • ACR50767.1
                                    		 20581 - 20994 (-) hypothetical protein
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                                      • ACR50768.1
                                      • tsn1
                                      		 21304 - 22122 (+) putative E2-like acyltransferase component of pyruvate/2-oxoglutarate dehydrogenase
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                                        • ACR50769.1
                                        • tsn2
                                        		 22160 - 23455 (-) E2 dihydrolipoyl acyltransferase
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                                          • ACR50770.1
                                          • tsn3
                                          		 23448 - 24464 (-) pyruvate dehydrogenase E1 beta subunit
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                                            • ACR50771.1
                                            • tsn4
                                            		 24443 - 25480 (-) pyruvate dehydrogenase E1 alpha subunit
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                                              • ACR50772.1
                                              • tsn5
                                              		 25477 - 25803 (-) acyl carrier protein
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                                                • ACR50773.1
                                                • tsnAII
                                                		 26101 - 41511 (+) polyketide synthase
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                                                  • ACR50774.1
                                                  • tsnAIII
                                                  		 41576 - 58468 (+) polyketide synthase
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                                                    • ACR50775.1
                                                    • tsnAIV
                                                    		 58540 - 76650 (+) polyketide synthase
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                                                      • ACR50776.1
                                                      • tsnB
                                                      		 76643 - 77062 (+) epoxide hydrolase
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                                                        • ACR50777.1
                                                        • tsn7
                                                        		 77059 - 78327 (+) putative major facilitator transporter
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                                                          • ACR50778.1
                                                          • tsn8
                                                          		 78441 - 79313 (-) methyltransferase
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                                                            • ACR50779.1
                                                            • tsn9
                                                            		 79594 - 80646 (+) putative 3-oxoacyl-ACP synthase III
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                                                              • ACR50780.1
                                                              • tsnC
                                                              		 80643 - 82076 (+) epoxidase
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                                                                • ACR50781.1
                                                                • tsn11
                                                                		 82195 - 83697 (-) putative FAD-dependent oxygenase
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                                                                  • ACR50782.1
                                                                  • tsnAV
                                                                  		 83714 - 88375 (-) polyketide synthase
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                                                                    • ACR50783.1
                                                                    • tsn12
                                                                    		 88582 - 89766 (-) P450 monooxygenase
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                                                                      • ACR50784.1
                                                                      • tsn13
                                                                      		 90030 - 91082 (+) putative 3-oxoacyl-ACP synthase III
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                                                                        • ACR50785.1
                                                                        • tsnAI
                                                                        		 91916 - 107005 (-) polyketide synthase
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                                                                          • ACR50786.1
                                                                          • tsn14
                                                                          		 107202 - 107738 (+) putative regulatory protein
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                                                                            • ACR50787.1
                                                                            • tsn15
                                                                            		 108020 - 109642 (-) putative ABC transporter, membrane spanning protein
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                                                                              • ACR50788.1
                                                                              • tsn16
                                                                              		 109639 - 110544 (-) putative ABC transporter, ATP binding component
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                                                                                • ACR50789.1
                                                                                • tsn17
                                                                                		 111072 - 111842 (+) putative pathway specific activator
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                                                                                  • ACR50790.1
                                                                                  • tsn18
                                                                                  		 112229 - 113113 (+) putative oxidoreductase
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                                                                                    • ACR50791.1
                                                                                    • tsnDIII
                                                                                    		 113739 - 120032 (+) putative polyketide synthase
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                                                                                      • ACR50792.1
                                                                                      • tsn19
                                                                                      		 120029 - 121591 (+) putative acyl-CoA synthase
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                                                                                        • ACR50793.1
                                                                                        • tsn20
                                                                                        		 121604 - 122875 (+) putative P450 monooxygenase
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                                                                                          • ACR50794.1
                                                                                          • tsn20a
                                                                                          		 123140 - 123907 (-) putative type II thioesterase
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                                                                                            • ACR50795.1
                                                                                            • tsnDII
                                                                                            		 123948 - 128456 (-) putative polyketide synthase
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                                                                                              • ACR50796.1
                                                                                              • tsnDI
                                                                                              		 128581 - 136011 (-) putative polyketide synthase
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                                                                                                • ACR50797.1
                                                                                                • tsn21
                                                                                                		 136385 - 138136 (+) acyltransferase
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                                                                                                  • ACR50798.1
                                                                                                  • tsn22
                                                                                                  		 138180 - 138929 (-) putative TetR-family transcriptional regulator
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                                                                                                    • ACR50799.1
                                                                                                    • tsn23
                                                                                                    		 138794 - 139933 (-) putative membrane protein
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                                                                                                      • ACR50800.1
                                                                                                      • tsn24
                                                                                                      		 140465 - 143221 (-) putative LuxR-family transcriptional regulator
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                                                                                                        • ACR50801.1
                                                                                                        • tsn25
                                                                                                        		 143949 - 144698 (-) putative methyltransferase
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                                                                                                          Biosynthesis information
                                                                                                          Annotation changelog

                                                                                                          Entry version: 4

                                                                                                          Date
                                                                                                          Changes
                                                                                                          Submitters
                                                                                                          Reviewers
                                                                                                          2022-10-07
                                                                                                          Update chemical activity to schema version 2.11
                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                          Entry version: 3

                                                                                                          Date
                                                                                                          Changes
                                                                                                          Submitters
                                                                                                          Reviewers
                                                                                                          2022-09-15
                                                                                                          Updated bioactivity data
                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                          Entry version: 2

                                                                                                          Date
                                                                                                          Changes
                                                                                                          Submitters
                                                                                                          Reviewers
                                                                                                          2019-10-16
                                                                                                          Migrated from v1.4
                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                          Entry version: 1

                                                                                                          Date
                                                                                                          Changes
                                                                                                          Submitters
                                                                                                          Reviewers
                                                                                                          2015-06-12
                                                                                                          Submitted
                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                          Detailed domain annotation
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