BGC0000201: auricin biosynthetic gene cluster from Streptomyces aureofaciens
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Location: 58,195 - 86,722 nt. (total: 28,528 nt).
This entry is originally from NCBI GenBank KJ396772.1.

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core biosynthetic genes
additional biosynthetic genes
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General
Compounds
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Polyketide
Saccharide
History
NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0000201
Short description auricin biosynthetic gene cluster from Streptomyces aureofaciens
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "Auricin is stable in acid and unstable in neutral and alkaline pH. It undergoes methanolysis (addition of methanol to the aglycon) "
Biosynthetic class(es)
  • Polyketide (Angucycline)
  • Saccharide (hybrid/tailoring)
Loci NCBI GenBank: KJ396772.1
Compounds
  • auricin
Species Streptomyces aureofaciens [taxonomy]
References
Chemical products information
auricin
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C28H31N1O10
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADM72849.2
  • aur1PR3
 58195 - 59016 (+) SARP-family auricin specific regulator
  • Regulation
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  • ADM72850.2
  • aur1PR2
 59319 - 60140 (+) SARP family transcriptional regulator
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  • ADM72851.2
 60257 - 60526 (+) putative acyl carrier protein
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  • ADM72852.2
 60624 - 61589 (+) polyketide cyclase/dehydrase
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  • ADM72853.2
  • aur1R
 61873 - 62490 (-) auricin-specific repressor of TetR family
  • Regulation
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  • AAX57187.2
  • aur1P
 62718 - 63488 (+) auricin-specific activator
  • Regulation
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  • AAK59995.3
  • aur1O
 63561 - 64442 (+) putative regulatory protein
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  • AAX57188.2
  • aur1A
 64713 - 66179 (+) auricin polyketide oxiygenase
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  • AAX57189.1
  • aur1B
 66354 - 67001 (+) TetR family transcriptional regulator
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  • AAX57190.1
  • aur1C
 67084 - 67416 (+) auricin polyketide cyclase
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  • AAX57191.1
  • aur1D
 67454 - 68722 (+) auricin polyketide beta-ketoacyl synthase alpha subunit
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  • AAX57192.2
  • aur1E
 68719 - 69936 (+) auricin polyketide beta-ketoacyl synthase beta subunit
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  • AAX57193.2
  • aur1F
 70034 - 70318 (+) auricin polyketide acyl carrier protein
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  • AAX57194.1
  • aur1G
 70411 - 71196 (+) auricin polyketide ketoreductase
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  • AAX57195.1
  • aur1H
 71231 - 72193 (+) auricin polyketide cyclase/dehydratase
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  • AAX57196.2
  • aur1I
 72196 - 74520 (+) auricin polyketide oxygenase-reductase
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  • AAX57197.2
  • aur1J
 74668 - 76143 (+) major facilitator superfamily transporter
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  • AAX57198.1
  • aur1K
 76209 - 76586 (+) hypothetical protein
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  • AAX57199.2
  • aur1L
 76583 - 77410 (+) 4'-phosphopantetheinyl transferase
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  • AAX57200.2
  • aur1M
 77441 - 78391 (+) malonyl CoA-acyl carrier protein transacylase
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  • AAX57201.2
  • aur1N
 78422 - 79984 (+) methylmalonyl-CoA carboxyltransferase
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  • ACK77742.1
  • aur1X2
 80020 - 80256 (+) hypothetical protein
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  • ACK77743.1
  • aur1T
 80344 - 81357 (+) NDP-D-glucose 4,6-dehydratase
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  • ACK77744.1
  • aur1Q
 81354 - 82658 (+) NDP-D-glucose 3,4-dehydratase
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  • ACK77745.2
  • aur1S
 82655 - 84052 (+) NDP-D-glucose 2,3-dehydratase
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  • AIE41917.1
  • aur1V
 84052 - 85017 (+) NDP-D-glucose 3-ketoreductase
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  • ACK77747.1
  • aur1X
 85090 - 85587 (+) hypothetical protein
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  • ACK77748.1
  • aur1W
 85595 - 85789 (+) hypothetical protein
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  • ACK77749.1
  • aur1U
 85817 - 86722 (+) putative acetyltransferase
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Polyketide-specific information
Subclass Angucycline
Cyclic? yes
Saccharide-specific information
Subclass hybrid/tailoring
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: NXKRPYNT3XZRYHGUED5OQBGH, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Compound's structure information updated
3.0
  • Hidden contributor (ID: 3UOU7PODQJXIM6BEPUHHRRA5, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Remove negative ketide_length
  • Removed polyketide annotations for missing genes
  • Removed precursor synthesis genes from different locus
  • Changed accession version
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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