BGC0000201: auricin biosynthetic gene cluster from Streptomyces aureofaciens
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Location: 58,195 - 86,722 nt. (total: 28,528 nt).
This entry is originally from NCBI GenBank KJ396772.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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General
Compounds
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Biosynthesis
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000201
Short description auricin biosynthetic gene cluster from Streptomyces aureofaciens
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "Auricin is stable in acid and unstable in neutral and alkaline pH. It undergoes methanolysis (addition of methanol to the aglycon) "
Biosynthetic class(es)
  • PKS (Unknown)
  • saccharide (hybrid/tailoring)
Loci
KJ396772.1
58195 - 86722
via Knock-out studies
Compounds
  • auricin
Species Streptomyces aureofaciens [taxonomy]
References
Chemical products information
auricin Evidence:
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C28H31N1O10
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADM72849.2
  • aur1PR3
 58195 - 59016 (+) SARP-family auricin specific regulator
  • Regulation
  • Knock-out
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  • ADM72850.2
  • aur1PR2
 59319 - 60140 (+) SARP family transcriptional regulator
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    • ADM72851.2
    		 60257 - 60526 (+) putative acyl carrier protein
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      • ADM72852.2
      		 60624 - 61589 (+) polyketide cyclase/dehydrase
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        • ADM72853.2
        • aur1R
        		 61873 - 62490 (-) auricin-specific repressor of TetR family
        • Regulation
        • Knock-out
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        • AAX57187.2
        • aur1P
        		 62718 - 63488 (+) auricin-specific activator
        • Regulation
        • Knock-out
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        • AAK59995.3
        • aur1O
        		 63561 - 64442 (+) putative regulatory protein
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          • AAX57188.2
          • aur1A
          		 64713 - 66179 (+) auricin polyketide oxiygenase
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            • AAX57189.1
            • aur1B
            		 66354 - 67001 (+) TetR family transcriptional regulator
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              • AAX57190.1
              • aur1C
              		 67084 - 67416 (+) auricin polyketide cyclase
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                • AAX57191.1
                • aur1D
                		 67454 - 68722 (+) auricin polyketide beta-ketoacyl synthase alpha subunit
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                  • AAX57192.2
                  • aur1E
                  		 68719 - 69936 (+) auricin polyketide beta-ketoacyl synthase beta subunit
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                    • AAX57193.2
                    • aur1F
                    		 70034 - 70318 (+) auricin polyketide acyl carrier protein
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                      • AAX57194.1
                      • aur1G
                      		 70411 - 71196 (+) auricin polyketide ketoreductase
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                        • AAX57195.1
                        • aur1H
                        		 71231 - 72193 (+) auricin polyketide cyclase/dehydratase
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                          • AAX57196.2
                          • aur1I
                          		 72196 - 74520 (+) auricin polyketide oxygenase-reductase
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                            • AAX57197.2
                            • aur1J
                            		 74668 - 76143 (+) major facilitator superfamily transporter
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                              • AAX57198.1
                              • aur1K
                              		 76209 - 76586 (+) hypothetical protein
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                                • AAX57199.2
                                • aur1L
                                		 76583 - 77410 (+) 4'-phosphopantetheinyl transferase
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                                  • AAX57200.2
                                  • aur1M
                                  		 77441 - 78391 (+) malonyl CoA-acyl carrier protein transacylase
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                                    • AAX57201.2
                                    • aur1N
                                    		 78422 - 79984 (+) methylmalonyl-CoA carboxyltransferase
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                                      • ACK77742.1
                                      • aur1X2
                                      		 80020 - 80256 (+) hypothetical protein
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                                        • ACK77743.1
                                        • aur1T
                                        		 80344 - 81357 (+) NDP-D-glucose 4,6-dehydratase
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                                          • ACK77744.1
                                          • aur1Q
                                          		 81354 - 82658 (+) NDP-D-glucose 3,4-dehydratase
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                                            • ACK77745.2
                                            • aur1S
                                            		 82655 - 84052 (+) NDP-D-glucose 2,3-dehydratase
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                                              • AIE41917.1
                                              • aur1V
                                              		 84052 - 85017 (+) NDP-D-glucose 3-ketoreductase
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                                                • ACK77747.1
                                                • aur1X
                                                		 85090 - 85587 (+) hypothetical protein
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                                                  • ACK77748.1
                                                  • aur1W
                                                  		 85595 - 85789 (+) hypothetical protein
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                                                    • ACK77749.1
                                                    • aur1U
                                                    		 85817 - 86722 (+) putative acetyltransferase
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                                                      Biosynthesis information
                                                      Annotation changelog

                                                      Entry version: 4

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2022-10-07
                                                      Update chemical activity to schema version 2.11
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 3

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2022-09-15
                                                      Remove negative ketide_length
                                                      • (ID: 3UOU7PODQJXIM6BEPUHHRRA5)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      2022-09-15
                                                      Removed polyketide annotations for missing genes
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      2022-09-15
                                                      Removed precursor synthesis genes from different locus
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      2022-09-15
                                                      Changed accession version
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 2

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2019-10-16
                                                      Migrated from v1.4
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      2019-10-16
                                                      Compound's structure information updated
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 1

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2015-06-12
                                                      Submitted
                                                      • (ID: NXKRPYNT3XZRYHGUED5OQBGH)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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