Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000201.1:
Cluster 1Polyketide / Saccharide128528

BGC0000201, auricin biosynthetic gene cluster from Streptomyces aureofaciens. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: auricin
Exact molecular mass: 542.2039 Da ([M+H]+)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
Polyketide / Saccharide
Polyketide subclass:
Angucycline (cyclic)
Polyketide synthase subclass:
Type II
Starter unit:
None
Polyketide synthase / ketosynthase-encoding genes:
61968692,662024112
Genes involved in folding/cyclization:
61968691, 61968695, 61968696

Gene cluster description

auricin (BGC0000201). Gene Cluster 1. Biosynthetic class = Polyketide/Saccharide. GenBank KJ396772, positions 16153-104444. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Comments:Auricin is stable in acid and unstable in neutral and alkaline pH. It undergoes methanolysis (addition of methanol to the aglycon)
Contact for this cluster:Jan Kormanec (Institute of Molecular Biology, Slovak Academy of Sciences)

Literature references

1. Novakova R et al. (2002) Cloning and characterization of a polyketide synthase gene cluster involved in biosynthesis of a proposed angucycline-like polyketide auricin in Streptomyces aureofaciens CCM 3239. Gene 297(1-2):197-208.
2. Novakova R et al. (2005) Characterization of a regulatory gene essential for the production of the angucycline-like polyketide antibiotic auricin in Streptomyces aureofaciens CCM 3239. Microbiology 151(Pt 8):2693-706. doi: 10.1099/mic.0.28019-0.
3. Novakova R et al. (2010) The role of the TetR-family transcriptional regulator Aur1R in negative regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239. Microbiology 156(Pt 8):2374-83. doi: 10.1099/mic.0.037895-0. Epub 2010
4. Novakova R et al. (2011) The role of two SARP family transcriptional regulators in regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239. Microbiology 157(Pt 6):1629-39. doi: 10.1099/mic.0.047795-0. Epub 2011
5. Kutas P et al. (2013) Strict control of auricin production in Streptomyces aureofaciens CCM 3239 involves a feedback mechanism. Appl Microbiol Biotechnol 97(6):2413-21. doi:
6. Novakova R et al. (2013) The gene cluster aur1 for the angucycline antibiotic auricin is located on a large linear plasmid pSA3239 in Streptomyces aureofaciens CCM 3239. FEMS Microbiol Lett 342(2):130-7. doi: 10.1111/1574-6968.12095. Epub
7. Rehakova A et al. (2013) A gene determining a new member of the SARP family contributes to transcription of genes for the synthesis of the angucycline polyketide auricin in Streptomyces aureofaciens CCM 3239. FEMS Microbiol Lett 346(1):45-55. doi: 10.1111/1574-6968.12200. Epub
8. Kormanec J et al. (2014) Intriguing properties of the angucycline antibiotic auricin and complex regulation of its biosynthesis. Appl Microbiol Biotechnol 98(1):45-60. doi: 10.1007/s00253-013-5373-0.
9. Mingyar E et al. (2015) A gamma-butyrolactone autoregulator-receptor system involved in the regulation of auricin production in Streptomyces aureofaciens CCM 3239. Appl Microbiol Biotechnol 99(1):309-25. doi: 10.1007/s00253-014-6057-0.