BGC0000203 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000203 (Amycolatopsis orientalis subsp. vinearia)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	48,405	High	BE-7585A	PKS

BGC0000203 - Region 1 - T2PKS

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Location: 1 - 48,405 nt. (total: 48,405 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 48,406
Label		BGC0000203

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

bexD: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

bexE: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

bexK: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

bexM: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

bexQ: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Transferases: aminotransferase carboxylase formyltransferase glycosyltransferase methyltransferase transferase

ADI71432.1: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

ADI71471.1: methionyl-tRNA formyltransferase

smcogs: SMCOG1228: methionyl-tRNA formyltransferase

bexG1: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

bexN: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

bexP: methyltransferase

smcogs: SMCOG1089: methyltransferase

bexT: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

bexU: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

Hydrolases: peptidase

ADI71470.1: gamma-glutamyltranspeptidase

smcogs: SMCOG1274: gamma-glutamyltranspeptidase

Lyases: cyclase dehydratase

bexF: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

bexL: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

bexS: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

bexA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

bexB: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000203.3	1.00	PKS	BE-7585A	Amycolatopsis orientalis subsp. vinearia
BGC0000231.5	0.82	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.79	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.77	PKS	oviedomycin	Streptomyces antibioticus
BGC0002672.2	0.60	PKS	saccharothrixin D, saccharothrixin E, saccharothrixin F, saccharothrixin G, saccharothrixin H, saccharothrixin I, saccharothrixin J, saccharothrixin K, saccharothrixin L, saccharothrixin M	Saccharothrix sp.
BGC0002070.3	0.60	PKS	SEK90, pentangumycin	Saccharothrix espanaensis DSM 44229
BGC0002047.2	0.59	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0002712.2	0.58	PKS	WS-5995 D, WS-5995 B, WS-5995 C, SEK 43	Streptomyces yanglinensis
BGC0002000.4	0.58	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0000235.5	0.58	PKS	kiamycin	Streptomyces sp. W007

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000203.3	1.00	PKS	BE-7585A	Amycolatopsis orientalis subsp. vinearia
BGC0000231.5	0.82	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.79	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.77	PKS	oviedomycin	Streptomyces antibioticus
BGC0002672.2	0.60	PKS	saccharothrixin D, saccharothrixin E, saccharothrixin F, saccharothrixin G, saccharothrixin H, saccharothrixin I, saccharothrixin J, saccharothrixin K, saccharothrixin L, saccharothrixin M	Saccharothrix sp.
BGC0002070.3	0.60	PKS	SEK90, pentangumycin	Saccharothrix espanaensis DSM 44229
BGC0002047.2	0.59	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0002712.2	0.58	PKS	WS-5995 D, WS-5995 B, WS-5995 C, SEK 43	Streptomyces yanglinensis
BGC0002000.4	0.58	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0000235.5	0.58	PKS	kiamycin	Streptomyces sp. W007

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 48405
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 683.9; E-value: 1.4e-208)
Product class(es):: angucycline
Product molecular weight(s):: acetyl-CoA_8: 561 Da
acetyl-CoA_9: 603 Da

bexA: KS (Score: 778.8; E-value: 2.6e-237)
bexB: CLF 8|9 (Score: 683.9; E-value: 1.4e-208)
bexC: ACP (Score: 111.5; E-value: 3.4e-35)
bexD: KR C9 (Score: 473.2; E-value: 4.6e-145)
bexE: OXY (Score: 603.6; E-value: 6.6e-184)
bexF: CYC C4-C17/C2-C19 (Score: 194.4; E-value: 4.3e-60)
bexG1: GT (Score: 428.7; E-value: 6.6e-131)
bexK: OXY (Score: 21.6; E-value: 2.2e-07)
bexL: CYC C7-C12 (Score: 476.0; E-value: 9.6e-146)
bexM: OXY (Score: 572.3; E-value: 2e-174)