BGC0000209 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000209 (Kitasatospora aureofaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	41,528	High	chlortetracycline	PKS

BGC0000209 - Region 1 - T2PKS

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Location: 1 - 41,528 nt. (total: 41,528 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 41,529
Label		BGC0000209

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

ctcE: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

ctcG: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

ctcN: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

ctcQ: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

ctcX: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Transferases: aminotransferase halogenase methyltransferase

ctcK: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

ctcL: aminotransferase

smcogs: SMCOG1019: aminotransferase

ctcO: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

ctcP: flavin-dependent cycline orsellinic halogenase

halogenases: flavin-dependent cycline orsellinic halogenase
smcogs: SMCOG1119: halogenase

Hydrolases: back translocase hydrolase

ctcC: GTP-binding protein LepA

smcogs: SMCOG1190: GTP-binding protein LepA

ctcT: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: cyclase hydratase

ctc4: Nitrilase/cyanide hydratase and apolipoprotein

smcogs: SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

ctcF: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: ligase synthase

ctcI: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

ctcV: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

ctcW: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000209.5	0.99	PKS	chlortetracycline	Kitasatospora aureofaciens
BGC0000234.5	0.66	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000231.5	0.65	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000272.3	0.61	PKS	spore pigment	Streptomyces collinus
BGC0002276.2	0.61	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002274.2	0.60	NRPS	aspulvinone H, aspulvinone B1	Aspergillus terreus NIH2624
BGC0001249.5	0.59	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001197.5	0.56	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001723.5	0.53	PKS	oviedomycin	Streptomyces antibioticus
BGC0000235.5	0.53	PKS	kiamycin	Streptomyces sp. W007

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000209.5	0.99	PKS	chlortetracycline	Kitasatospora aureofaciens
BGC0000234.5	0.66	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000231.5	0.65	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000272.3	0.61	PKS	spore pigment	Streptomyces collinus
BGC0002276.2	0.61	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002274.2	0.60	NRPS	aspulvinone H, aspulvinone B1	Aspergillus terreus NIH2624
BGC0001249.5	0.59	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001197.5	0.56	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001723.5	0.53	PKS	oviedomycin	Streptomyces antibioticus
BGC0000235.5	0.53	PKS	kiamycin	Streptomyces sp. W007

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

ctcI: X

AMP-binding (30..420): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: SFMYLGGPSK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 0 to 41528
Starter unit(s):: malonamyl-CoA (Score: 2237.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 672.5; E-value: 4e-205)
Product class(es):: anthracycline
aureolic acid
tetracycline
Product molecular weight(s):: malonamyl-CoA_8: 473 Da
malonamyl-CoA_9: 515 Da

ctcD: CYC C5-C14/C3-C16 (Score: 435.9; E-value: 1.1e-133)
ctcE: OXY (Score: 433.8; E-value: 2e-132)
ctcF: CYC C7-C12 (Score: 439.0; E-value: 1.8e-134)
ctcG: KR C9 (Score: 445.3; E-value: 1.5e-136)
ctcH: CYC C1-C18|C2-C19 (Score: 230.8; E-value: 1.1e-71)
ctcI: LIG (Score: 764.1; E-value: 1.3e-232); LIG AEI98652.1_Chlortetracycline_malonamyl-CoA (Score: 1024.0; E-value: 0.0)
ctcK: MET C6|C8 (Score: 584.7; E-value: 1e-178)
ctcL: AMIN (Score: 618.7; E-value: 7e-189)
ctcN: OXY (Score: 475.7; E-value: 4.1e-145)
ctcO: MET C2O|C2N (Score: 608.8; E-value: 5.6e-186)
ctcP: HAL (Score: 740.5; E-value: 1.6e-225)
ctcT: AMID (Score: 1192.5; E-value: 0.0); AMID AEI98663.1_Chlortetracycline_malonamyl-CoA (Score: 1213.0; E-value: 0.0)
ctcU: ACP (Score: 110.7; E-value: 6e-35)
ctcV: CLF 8|9 (Score: 672.5; E-value: 4e-205)
ctcW: KS (Score: 745.5; E-value: 3.5e-227)
ctcX: OXY (Score: 208.2; E-value: 5.4e-64)