BGC0000213: colabomycin E biosynthetic gene cluster from Streptomyces aureus
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Location: 1 - 46,538 nt. (total: 46,538 nt).
This entry is originally from NCBI GenBank KF850685.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000213
Short description colabomycin E biosynthetic gene cluster from Streptomyces aureus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type II)
Loci
KF850685.1
via Knock-out studies, Heterologous expression, Gene expression correlated with compound production
Compounds
  • colabomycin E
Species Streptomyces aureus [taxonomy]
References
Chemical products information
colabomycin E Evidence:
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C32H32N2O7
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AIL50152.1
 205 - 858 (+) hypothetical protein
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    • AIL50153.1
    		 855 - 2408 (+) hypothetical protein
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      • AIL50154.1
      		 2405 - 4351 (+) hypothetical protein
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        • AIL50156.1
        		 4424 - 5776 (+) putative dioxygenase
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          • AIL50155.1
          		 5782 - 7218 (+) putative glutamine synthetase
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            • AIL50157.1
            		 7235 - 8377 (+) putative oxidoreductase
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              • AIL50158.1
              		 8251 - 9963 (-) putative feruolyl esterase
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                • AIL50159.1
                		 10258 - 11232 (+) putative nitrate ABC transport substrate-binding protein
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                  • AIL50160.1
                  		 11246 - 12421 (-) putative cytochrome P450
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                    • AIL50161.1
                    		 12596 - 14581 (+) hypothetical protein
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                      • AIL50162.1
                      • colH1
                      		 14631 - 15533 (-) hypothetical protein
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                        • AIL50163.1
                        • colR5
                        		 15655 - 16407 (-) regulatory protein
                        • Regulation
                        • Knock-out Other in vivo study
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                        • AIL50164.1
                        • colC16
                        		 16644 - 17378 (-) DSBA oxido/reductase
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                          • AIL50165.1
                          • colC3
                          		 17366 - 18505 (-) hypothetical protein
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                            • AIL50166.1
                            • colC4
                            		 18502 - 19710 (-) putative beta-ketoacyl synthase
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                              • AIL50167.1
                              • colC5
                              		 19712 - 19966 (-) putative ACP
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                                • AIL50168.1
                                • colC10
                                		 20026 - 20766 (-) putative ketoreductase
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                                  • AIL50169.1
                                  • colC2
                                  		 20766 - 21623 (-) putative arylamine N-acetyltransferase
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                                    • AIL50170.1
                                    • colM1
                                    		 21914 - 23440 (-) putative transport protein
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                                      • AIL50171.1
                                      • colC15
                                      		 23534 - 24313 (-) putative type II thioesterase
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                                        • AIL50172.1
                                        • colC9
                                        		 24310 - 25113 (-) putative acyl dehydratase
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                                          • AIL50173.1
                                          • colC8
                                          		 25113 - 25547 (-) putative acyl dehydratase
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                                            • AIL50174.1
                                            • colA2
                                            		 25544 - 26953 (-) putative 3,4-AHBA carboxyl group adenylase
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                                              • AIL50175.1
                                              • colA1
                                              		 26971 - 28098 (-) putative 3,4-AHBA synthase
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                                                • AIL50176.1
                                                • colA3
                                                		 28393 - 29208 (+) putative 2-amino-4,5-dihydroxy-6-one-heptanoic acid-7-phosphate synthase
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                                                  • AIL50177.1
                                                  • colC11
                                                  		 29304 - 29582 (+) putative ACP
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                                                    • AIL50178.1
                                                    • colC12
                                                    		 29579 - 29860 (+) putative 3,4-AHBA ACP
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                                                      • AIL50179.1
                                                      • colC13
                                                      		 29850 - 31043 (+) putative type II PKS ketosynthase alpha subunit
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                                                        • AIL50180.1
                                                        • colC14
                                                        		 31098 - 31835 (+) putative beta-ketoacyl synthase beta subunit (CLF)
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                                                          • AIL50181.1
                                                          • colE3
                                                          		 31846 - 32970 (+) putative 4-hydroxyprotocolabomycin epoxidase
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                                                            • AIL50182.1
                                                            • colC7
                                                            		 33051 - 33755 (-) putative ketoreductase
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                                                              • AIL50183.1
                                                              • colE2
                                                              		 33854 - 34387 (-) putative flavin reductase
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                                                                • AIL50184.1
                                                                • colC6
                                                                		 34403 - 34858 (-) putative thioesterase
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                                                                  • AIL50187.1
                                                                  • colR2
                                                                  		 35095 - 35673 (-) putative TetR family transcriptional regulator
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                                                                    • AIL50186.1
                                                                    • colR1
                                                                    		 35716 - 36357 (-) putative transcriptional regulator
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                                                                      • AIL50185.1
                                                                      • colC1
                                                                      		 36419 - 37126 (-) putative phosphopantetheinyl transferase
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                                                                        • AIL50188.1
                                                                        • colE1
                                                                        		 37513 - 38730 (+) putative protocolabomycin 4-hydroxylase
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                                                                          • AIL50189.1
                                                                          • colD3
                                                                          		 38800 - 40341 (-) putative 5-aminolevulinate CoA-ligase
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                                                                            • AIL50190.1
                                                                            • colD2
                                                                            		 40417 - 41646 (-) putative 5-aminolevulinate synthase
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                                                                              • AIL50191.1
                                                                              • colD1
                                                                              		 41726 - 43279 (-) putative amide synthetase
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                                                                                • AIL50192.1
                                                                                • colR3
                                                                                		 43561 - 44136 (-) putative TetR family transcriptional regulator
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                                                                                  • AIL50193.1
                                                                                  		 44298 - 44936 (+) hypothetical protein
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                                                                                    • AIL50194.1
                                                                                    		 44985 - 45716 (-) hypothetical protein
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                                                                                      • AIL50195.1
                                                                                      		 46301 - >46538 (+) hypothetical protein
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                                                                                        Biosynthesis information

                                                                                        No biosynthesis information available for this record.

                                                                                        Annotation changelog

                                                                                        Entry version: 3

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2022-10-07
                                                                                        Update chemical activity to schema version 2.11
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                        Entry version: 2

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2019-10-16
                                                                                        Migrated from v1.4
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                        Entry version: 1

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2015-06-12
                                                                                        Submitted
                                                                                        • (ID: XHMATMYJAZTXOWXACEUS7VTO)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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