BGC0000218: doxorubicin biosynthetic gene cluster from Streptomyces peucetius
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Location: 1 - 8,737 nt. (total: 8,737 nt).
This entry is originally from NCBI GenBank L35560.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000218
Short description doxorubicin biosynthetic gene cluster from Streptomyces peucetius
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
L35560.1
via
Compounds
  • doxorubicin
Species Streptomyces peucetius [taxonomy]
References
Chemical products information
doxorubicin Evidence:
Copy SMILES
C27H29N1O11
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAA65202.1
  • dnrH
 28 - 783 (+) daunorubicin-doxorubicin polyketide synthase
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    • AAA65203.1
    • dpsF
    		 918 - 1865 (-) daunorubicin-doxorubicin polyketide synthase
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      • AAA65204.1
      • dpsE
      		 1895 - 2680 (-) daunorubicin-doxorubicin polyketide synthase
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        • AAA65205.1
        		 2872 - 3261 (+) anthraquinol monooxygenase
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          • AAA65206.1
          • dpsA
          		 3258 - 4517 (+) daunorubicin-doxorubicin polyketide synthase
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            • AAA65207.1
            • dpsB
            		 4523 - 5800 (+) daunorubicin-doxorubicin polyketide synthase
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              • AAA65208.1
              • dpsC
              		 5797 - 6858 (+) daunorubicin-doxorubicin polyketide synthase
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                • AAA65209.1
                • dpsD
                		 6869 - 7882 (+) daunorubicin-doxorubicin polyketide synthase
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                  • AAA65210.1
                  		 7860 - 8720 (-)
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                    Biosynthesis information
                    Annotation changelog

                    Entry version: 4

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-10-07
                    Update chemical activity to schema version 2.11
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 3

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-09-15
                    Updated bioactivity data
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 2

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2019-10-16
                    Migrated from v1.4
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 1

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2015-06-12
                    Submitted
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    Detailed domain annotation
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