BGC0000219: elloramycin biosynthetic gene cluster from Streptomyces olivaceus
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Location: 1 - 24,201 nt. (total: 24,201 nt).
This entry is originally from NCBI GenBank AM900040.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000219
Short description elloramycin biosynthetic gene cluster from Streptomyces olivaceus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "Elloramycin is a hybrid compound comprising a tetracenomycin scaffold and a sugar moiety. A second genomic loci comprises the Rha cluster - accession number: AM889123, Responsible for saccharide biosynthesis. Biosynthesis is discussed in PubMed ID: 18310024."
Biosynthetic class(es)
  • PKS (Type II)
  • saccharide (hybrid/tailoring)
Loci
AM900040.1
via Knock-out studies, Heterologous expression
Compounds
  • elloramycin
Species Streptomyces olivaceus [taxonomy]
References
Chemical products information
elloramycin Evidence:
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C32H36O15
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAP12590.1
 3 - 404 (+) dehydrogenase
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    • CAP12591.1
    		 414 - 1085 (+) phosphatase
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      • CAP12592.1
      		 1169 - 1720 (+) membrane protein
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        • CAP12593.1
        • elmD
        		 1920 - 2807 (+) C12a O-methyltransferase
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          • CAP12594.1
          • elmE
          		 3099 - 4658 (+) elloramycin permease
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            • CAP12595.1
            • elmF
            		 4676 - 5875 (+) ElmF protein
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              • CAP12596.1
              • elmG
              		 6162 - 7781 (+) TcmB2 oxygenase
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                • CAP12597.1
                • elmH
                		 7813 - 8142 (+) TcmF1 monooxygenase
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                  • CAP12598.1
                  • elmI
                  		 8169 - 8459 (+) TcmF2 cyclase
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                    • CAP12599.1
                    • elmJ
                    		 8471 - 8902 (+) third ring cyclase
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                      • CAP12600.1
                      • elmK
                      		 8899 - 10170 (+) ketoacyl synthase alpha
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                        • CAP12601.1
                        • elmL
                        		 10167 - 11402 (+) ketoacyl synthase beta
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                          • CAP12602.1
                          • elmM
                          		 11429 - 11680 (+) acyl carrier protein
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                            • CAP12603.1
                            • elmNI
                            		 11677 - 12135 (+) aromatase
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                              • CAP12604.1
                              • elmNII
                              		 12132 - 13181 (+) C3 O-methyltransferase
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                                • CAP12605.1
                                • elmP
                                		 13178 - 14008 (+) carboxyl O-methyltransferase
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                                  • CAP12606.1
                                  • elmMI
                                  		 14028 - 15164 (+) rhamnose C2'-methyltransferase
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                                    • CAP12607.1
                                    • elmGT
                                    		 15166 - 16314 (+) glycosyltransferase
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                                      • CAP12608.1
                                      • elmMII
                                      		 16311 - 17483 (+) rhamnose C3'-methyltransferase
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                                        • CAP12609.1
                                        • elmMIII
                                        		 17510 - 18295 (+) rhamnose C4'-methyltransferase
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                                          • CAP12610.1
                                          		 18668 - 19450 (+) dehydrogenase
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                                            • CAP12611.1
                                            		 19447 - 20376 (+) lipase
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                                              • CAP12612.1
                                              		 20417 - 21655 (-) solute binding protein
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                                                • CAP12613.1
                                                		 21952 - 23718 (-) VanW-like protein
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                                                  • CAP12614.1
                                                  		 23835 - >24201 (+) IclR-family regulator
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                                                    Biosynthesis information
                                                    Annotation changelog

                                                    Entry version: 3

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2022-10-07
                                                    Update chemical activity to schema version 2.11
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 2

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2019-10-16
                                                    Migrated from v1.4
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 1

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2015-06-12
                                                    Submitted
                                                    • (ID: IROSGRAECON7XFWB774QFHDN)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    Detailed domain annotation
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