BGC0000222 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000222 (Streptomyces sp. TA-0256)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	43,026	High	FD-594	PKS

BGC0000222 - Region 1 - T2PKS

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Location: 1 - 43,026 nt. (total: 43,026 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 43,027
Label		BGC0000222

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

pnxG: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

pnxO1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

pnxO2: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

pnxO3: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

pnxO4: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

pnxO5: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

pnxO6: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

pnxO7: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

pnxS4: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

pnxW: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acylase glycosyltransferase transferase

pnxGT1: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

pnxGT2: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

pnxJ: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

pnxS1: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

Lyases: cyclase dehydratase

pnxD: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

pnxK: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

pnxS2: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

pnxS5: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

pnxA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

pnxB: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

pnxU: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000222.5	1.00	PKS	FD-594	Streptomyces sp. TA-0256
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0000275.4	0.64	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0000278.3	0.63	PKS	urdamycin	Streptomyces fradiae
BGC0001160.5	0.63	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001257.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002175.3	0.63	PKS	YWA1	Aspergillus oryzae RIB40
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001164.3	0.63	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001258.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000222.5	1.00	PKS	FD-594	Streptomyces sp. TA-0256
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0000275.4	0.64	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0000278.3	0.63	PKS	urdamycin	Streptomyces fradiae
BGC0001160.5	0.63	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001257.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002175.3	0.63	PKS	YWA1	Aspergillus oryzae RIB40
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001164.3	0.63	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001258.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

pnxJ: mal

PKS_AT (14..294): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 50.0
Methoxymalonyl-CoA: 36.4
Methylmalonyl-CoA: 34.1
inactive: 27.6
fatty_acid: 22.3
Isobutyryl-CoA: 13.3
Propionyl-CoA: 12.7
2-Methylbutyryl-CoA: 10.3
Ethylmalonyl-CoA: 9.8
Benzoyl-CoA: 8.3
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 0 to 43026
Starter unit(s):: butyryl-CoA (Score: 1302.0; E-value: 0)
Malonyl elongations:: 11|12 (Score: 689.6; E-value: 2.5e-210)
Product class(es):: pentangular polyphenol
Product molecular weight(s):: butyryl-CoA_11: 882 Da
butyryl-CoA_12: 924 Da

pnxA: KS (Score: 730.4; E-value: 1.3e-222)
pnxB: CLF 11|12 (Score: 689.6; E-value: 2.5e-210)
pnxC: ACP (Score: 114.9; E-value: 3e-36)
pnxD: CYC C9-C14 (Score: 246.5; E-value: 1.8e-76)
pnxG: KR C19 (Score: 433.5; E-value: 5.3e-133)
pnxGT1: GT (Score: 292.7; E-value: 1.3e-89)
pnxGT2: GT (Score: 407.3; E-value: 2e-124)
pnxJ: AT (Score: 413.6; E-value: 1.4e-126); AT BAJ52678.1_FD-594_butyryl-CoA (Score: 643.0; E-value: 0.0)
pnxK: CYC C4-C21/C2-C23|C2-C19 (Score: 170.9; E-value: 1.4e-53)
pnxL: CYC C5-C18 (Score: 225.3; E-value: 4.2e-70)
pnxMT1: MET (Score: 46.9; E-value: 4.6e-15)
pnxO1: KR (Score: 104.4; E-value: 1.8e-32)
pnxO4: OXY (Score: 296.4; E-value: 1e-90)
pnxO6: OXY (Score: 250.9; E-value: 6.3e-77)
pnxU: KSIII (Score: 427.6; E-value: 7.6e-131); KSIII BAJ52704.1_FD-594_butyryl-CoA (Score: 659.0; E-value: 0.0)
pnxV: ACP (Score: 73.1; E-value: 3.2e-23)
pnxW: KR C11 (Score: 423.8; E-value: 4.4e-130)