BGC0000232 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000232 (Streptomyces sp. 2238-SVT4)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	34,927	High	hatomarubigin A/hatomarubigin B/hatomarubigin C/hatomarubigin D	PKS

BGC0000232 - Region 1 - T2PKS

Download region GenBank file

Download region SVG

Location: 1 - 34,927 nt. (total: 34,927 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 34,928
Label		BGC0000232

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

hrbG: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

hrbH: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

hrbI: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

hrbL: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

hrbO: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

hrbR: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

hrbS: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

hrbV: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

hrbX: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

hrbY: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

hrbZ1: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

hrbZ2: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: PPTase kinase methyltransferase

BAJ07870.1: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

hrbQ: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

hrbU: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Lyases: cyclase

hrbB: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

hrbP: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

hrbC: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

hrbE: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000232.5	1.00	PKS	hatomarubigin A, hatomarubigin B, hatomarubigin C, hatomarubigin D	Streptomyces sp. 2238-SVT4
BGC0000231.5	0.74	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.70	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002276.2	0.58	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000272.3	0.56	PKS	spore pigment	Streptomyces collinus
BGC0001197.5	0.56	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001895.4	0.56	PKS	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0000271.5	0.56	PKS	spore pigment	Streptomyces avermitilis
BGC0001366.5	0.55	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0001513.3	0.54	PKS	anthrabenzoxocinone	Actinobacteria bacterium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000232.5	1.00	PKS	hatomarubigin A, hatomarubigin B, hatomarubigin C, hatomarubigin D	Streptomyces sp. 2238-SVT4
BGC0000231.5	0.74	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.70	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002276.2	0.58	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000272.3	0.56	PKS	spore pigment	Streptomyces collinus
BGC0001197.5	0.56	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001895.4	0.56	PKS	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0000271.5	0.56	PKS	spore pigment	Streptomyces avermitilis
BGC0001366.5	0.55	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0001513.3	0.54	PKS	anthrabenzoxocinone	Actinobacteria bacterium

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 34927
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 705.4; E-value: 4e-215)
Product class(es):: angucycline
Product molecular weight(s):: acetyl-CoA_8: 406 Da
acetyl-CoA_9: 448 Da

hrbB: CYC C4-C17/C2-C19 (Score: 183.0; E-value: 1.3e-56)
hrbC: KS (Score: 778.9; E-value: 2.5e-237)
hrbE: CLF 8|9 (Score: 705.4; E-value: 4e-215)
hrbG: OXY (Score: 609.3; E-value: 1.2e-185)
hrbI: KR (Score: 152.7; E-value: 3.4e-47)
hrbM: ACP (Score: 125.5; E-value: 1.4e-39)
hrbO: KR C9 (Score: 481.7; E-value: 1.1e-147)
hrbP: CYC C7-C12 (Score: 495.2; E-value: 1.3e-151)
hrbR: OXY (Score: 535.6; E-value: 2.8e-163)
hrbS: KR (Score: 127.5; E-value: 1.6e-39)
hrbU: MET (Score: 288.3; E-value: 1.8e-88)
hrbV: KR (Score: 110.0; E-value: 3.5e-34)
hrbW: KR (Score: 43.4; E-value: 7.3e-14)
hrbX: OXY (Score: 17.0; E-value: 5.5e-06)
hrbY: DIMER (Score: 404.0; E-value: 7.8e-124)
hrbZ2: KR (Score: 38.2; E-value: 2.9e-12)