BGC0000233: hedamycin biosynthetic gene cluster from Streptomyces griseoruber
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Location: 1 - 45,603 nt. (total: 45,603 nt).
This entry is originally from NCBI GenBank AY196994.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000233
Short description hedamycin biosynthetic gene cluster from Streptomyces griseoruber
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
AY196994.1
via
Compounds
  • hedamycin
Species Streptomyces griseoruber [taxonomy]
References
Chemical products information
hedamycin Evidence:
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C41H50N2O11
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAP85335.1
 1 - 6378 (-) type I PKS
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    • AAP85336.1
    		 6375 - 9332 (-) type I PKS
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      • AAP85337.1
      		 9388 - 10434 (-) putative 3-oxoacyl-ACP synthase
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        • AAP85338.1
        		 10511 - 11740 (-) cytochrome P450
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          • AAP85339.1
          		 11885 - 14167 (-) UvrA-like drug resistance protein
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            • AAP85340.1
            		 14164 - 14511 (-) anthrone oxygenase
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              • AAP85341.1
              		 14549 - 15991 (-) 2,3-hexose dehydratase
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                • AAP85342.1
                		 16172 - 16993 (-) putative hydroxylase
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                  • AAP85343.1
                  		 17084 - 18130 (+) transcription repressor
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                    • AAP85344.1
                    		 18085 - 18771 (-) ACP-phosphodiesterase
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                      • AAP85345.1
                      		 18843 - 19562 (-) putative N,N-dimethyltransferase
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                        • AAP85346.1
                        		 19783 - 20748 (+) diphospho-4-keto-2,3,6-trideoxyhexulose reductase
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                          • AAP85347.1
                          		 20750 - 21868 (+) aminotransferase
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                            • AAP85348.1
                            		 21967 - 23109 (-) glycosyltransferase
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                              • AAP85349.1
                              		 23172 - 23954 (-) ABC transporter
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                                • AAP85350.1
                                		 23972 - 24976 (-) ATP-binding protein
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                                  • AAP85351.1
                                  		 26379 - 27197 (-) putative regulatory protein
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                                    • AAP85352.1
                                    		 27493 - 28587 (-) hypothetical protein
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                                      • AAP85353.1
                                      		 28743 - 29423 (+) putative 3-5-epimerase
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                                        • AAP85354.1
                                        		 29467 - 30606 (+) glycosyltransferase
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                                          • AAP85355.1
                                          		 30644 - 31621 (+) probable dTDP-4-keto-6-deoxyhexose reductase
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                                            • AAP85356.1
                                            		 31640 - 32368 (-) N,N-dimethyltransferase
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                                              • AAP85357.1
                                              		 32374 - 33609 (-) putative monooxygenase
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                                                • AAP85358.1
                                                		 33606 - 35231 (-) putative secreted tripeptidylaminopeptidase
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                                                  • AAP85359.1
                                                  		 35293 - 36270 (+) putative acyltransferase
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                                                    • AAP85360.1
                                                    		 36538 - 37497 (+) putative bifunctional cyclase dehydratase and ACP fusion
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                                                      • AAP85361.1
                                                      		 37469 - 38734 (-) keto synthase beta
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                                                        • AAP85362.1
                                                        		 38731 - 39999 (-) putative keto synthase alpha
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                                                          • AAP85363.1
                                                          		 40439 - 41404 (+) cyclase
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                                                            • AAP85364.1
                                                            		 41609 - 42388 (+) keto reductase
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                                                              • AAP85365.1
                                                              		 43426 - 44094 (-) putative TetR-family regulatory protein
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                                                                • AAP85366.1
                                                                		 44086 - 45603 (+) membrane transport protein
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                                                                  Biosynthesis information
                                                                  Annotation changelog

                                                                  Entry version: 4

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2022-10-07
                                                                  Update chemical activity to schema version 2.11
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 3

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2022-09-15
                                                                  Updated bioactivity data
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 2

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2019-10-16
                                                                  Migrated from v1.4
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  2019-10-16
                                                                  Updated compound(s) information (NPAtlas curation)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 1

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2015-06-12
                                                                  Submitted
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  Detailed domain annotation
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