BGC0000237 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000237 (Streptomyces sanglieri)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	12,707	High	lactonamycin Z	PKS

BGC0000237 - Region 1 - T2PKS

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Location: 1 - 12,707 nt. (total: 12,707 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 12,708
Label		BGC0000237

Tailoring functions

Transferases: glycosyltransferase methyltransferase

lcz25: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

lcz35: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

lcz36: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

Hydrolases: esterase

lcz34: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: cyclase

lcz27: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

lcz29: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

Ligases: ligase synthase

lcz28: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

lcz31: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

lcz32: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000237.5	0.98	PKS	lactonamycin Z	Streptomyces sanglieri
BGC0000231.5	0.62	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001641.4	0.61	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000272.3	0.61	PKS	spore pigment	Streptomyces collinus
BGC0000275.4	0.60	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae
BGC0001240.4	0.60	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001261.3	0.60	NRPS	AM-toxin	Alternaria alternata
BGC0000357.5	0.59	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001250.4	0.59	NRPS	epichloenin A	Epichloe festucae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000237.5	0.98	PKS	lactonamycin Z	Streptomyces sanglieri
BGC0000231.5	0.62	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001641.4	0.61	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000272.3	0.61	PKS	spore pigment	Streptomyces collinus
BGC0000275.4	0.60	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae
BGC0001240.4	0.60	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001261.3	0.60	NRPS	AM-toxin	Alternaria alternata
BGC0000357.5	0.59	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001250.4	0.59	NRPS	epichloenin A	Epichloe festucae

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

lcz28: Gly

Search NORINE for peptide: strict or relaxed

AMP-binding (11..419): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DLFFLCLLSK
Nearest Stachelhaus code(s):: Gly DLFFLCLLSK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 0 to 12707
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 657.9; E-value: 1.1e-200)
Product class(es):: tetracenomycin
Product molecular weight(s):: acetyl-CoA_8: 525 Da
acetyl-CoA_9: 567 Da

lcz24: ACP (Score: 108.9; E-value: 2.2e-34)
lcz25: MET C11O (Score: 532.7; E-value: 7.6e-163)
lcz26: ACP (Score: 32.0; E-value: 2.1e-10)
lcz27: CYC C9-C14 (Score: 237.3; E-value: 1.2e-73)
lcz29: CYC C4-C21/C2-C23|C2-C19 (Score: 142.1; E-value: 1.3e-44)
lcz30: CYC C5-C18 (Score: 191.0; E-value: 1.6e-59)
lcz31: KS (Score: 709.5; E-value: 2.9e-216)
lcz32: CLF 8|9 (Score: 657.9; E-value: 1.1e-200)
lcz35: MET C13O|C17O (Score: 520.6; E-value: 3.3e-159)
lcz36: GT (Score: 468.4; E-value: 5.7e-143)