BGC0000237 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000237 (Streptomyces sanglieri)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS	1	12,707	lactonamycin Z	PKS	100%

BGC0000237 - Region 1 - T2PKS

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Location: 1 - 12,707 nt. (total: 12,707 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 12,708
Label		BGC0000237

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000237	1.00	Polyketide	lactonamycin Z	Streptomyces sanglieri
BGC0001925	0.28	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0000231	0.28	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000272	0.28	Polyketide	spore pigment	Streptomyces collinus
BGC0000196	0.28	Polyketide	AQ-256, AQ-270a, AQ-284a	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000238	0.27	Polyketide	lactonamycin	Streptomyces rishiriensis
BGC0000275	0.27	Polyketide	tetracenomycin C	Streptomyces glaucescens
BGC0000265	0.26	Polyketide	rhodomycin	Streptomyces purpurascens
BGC0001723	0.25	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000234	0.25	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000237	1.00	Polyketide	lactonamycin Z	Streptomyces sanglieri
BGC0001925	0.62	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0000231	0.62	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000272	0.61	Polyketide	spore pigment	Streptomyces collinus
BGC0000196	0.61	Polyketide	AQ-256, AQ-270a, AQ-284a	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000238	0.61	Polyketide	lactonamycin	Streptomyces rishiriensis
BGC0000275	0.60	Polyketide	tetracenomycin C	Streptomyces glaucescens
BGC0000265	0.59	Polyketide	rhodomycin	Streptomyces purpurascens
BGC0001723	0.58	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000234	0.58	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

lcz28

Search NORINE for peptide: strict or relaxed

AMP-binding (11..419): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DLFFLCLLSK
Nearest Stachelhaus code(s):: Gly DLFFLCLLSK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

Type II PKS gene cluster prediction details

Cluster section:: 0 to 12707
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 657.9; E-value: 1.1e-200)
Product class(es):: tetracenomycin
Product molecular weight(s):: acetyl-CoA_8: 525 Da
acetyl-CoA_9: 567 Da

lcz24: ACP (Score: 108.9; E-value: 2.2e-34)
lcz25: MET C11O (Score: 532.7; E-value: 7.6e-163)
lcz26: ACP (Score: 32.0; E-value: 2.1e-10)
lcz27: CYC C9-C14 (Score: 237.3; E-value: 1.2e-73)
lcz29: CYC C4-C21/C2-C23|C2-C19 (Score: 142.1; E-value: 1.3e-44)
lcz30: CYC C5-C18 (Score: 191.0; E-value: 1.6e-59)
lcz31: KS (Score: 709.5; E-value: 2.9e-216)
lcz32: CLF 8|9 (Score: 657.9; E-value: 1.1e-200)
lcz35: MET C13O|C17O (Score: 520.6; E-value: 3.3e-159)
lcz36: GT (Score: 468.4; E-value: 5.7e-143)