BGC0000245: medermycin biosynthetic gene cluster from Streptomyces sp. AM-7161
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Location: 1 - 36,202 nt. (total: 36,202 nt).
This entry is originally from NCBI GenBank AB103463.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000245
Short description medermycin biosynthetic gene cluster from Streptomyces sp. AM-7161
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
AB103463.1
via
Compounds
  • medermycin
Species Streptomyces sp. AM-7161 [taxonomy]
References
Chemical products information
medermycin Evidence:
Copy SMILES
C24H27N1O7
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAC79013.1
  • ORF_P
 1 - 651 (-) sulfate adenylyltransferase
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    • BAC79014.1
    • ORF_Q
    		 648 - 1181 (-) adenylylsulfate kinase
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      • BAC79015.1
      • ORF_R
      		 1211 - 1918 (-) phosphoadenosine phosphosulfate reductase
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        • BAC79016.1
        • ORF_X
        		 2091 - 3785 (-) nitrite/sulphite reductase
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          • BAC79017.1
          • ORF_Y
          		 4149 - 4718 (-) acetyltransferase
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            • BAC79018.1
            • med-ORF30
            		 5000 - 5680 (+) repressor-response regulator
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              • BAC79019.1
              • med-ORF26
              		 5738 - 6358 (-) putative disulphide-forming protein
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                • BAC79020.1
                • med-ORF25
                		 6374 - 7951 (-) transmembrane transport protein
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                  • BAC79021.1
                  • med-ORF29
                  		 7948 - 8973 (-) enoyl reductase
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                    • BAC79022.1
                    • med-ORF28
                    		 9056 - 9697 (+) Tet-R family transcriptional regulator
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                      • BAC79023.1
                      • med-ORF27
                      		 9739 - 10785 (-) unknown
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                        • BAC79024.1
                        • med-ORF23
                        		 11211 - 11486 (+) acyl carrier protein (ACP)
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                          • BAC79025.1
                          • med-ORF24
                          		 11536 - 12252 (+) phosphopantetheinyl transferase
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                            • BAC79026.1
                            • med-ORF22
                            		 12287 - 13903 (+) decarboxylase
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                              • BAC79027.1
                              • med-ORF19
                              		 13942 - 14898 (+) first ring aromatase (ARO)
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                                • BAC79028.1
                                • med-ORF20
                                		 14936 - 16066 (+) NDP-deoxyhexose 3-aminotransferase
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                                  • BAC79029.1
                                  • med-ORF18
                                  		 16063 - 17127 (+) NDP-1-glucose synthase
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                                    • BAC79030.1
                                    • med-ORF17
                                    		 17124 - 18125 (+) NDP-glucose-4,6-dehydratase
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                                      • BAC79031.1
                                      • med-ORF16
                                      		 18122 - 19561 (+) NDP-deoxyglucose-2,3-dehydratase
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                                        • BAC79032.1
                                        • med-ORF15
                                        		 19612 - 20334 (+) N-methyl transferase
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                                          • BAC79033.1
                                          • med-ORF14
                                          		 20331 - 21308 (+) NDP-4-keto-6-deoxyhexose reductase
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                                            • BAC79034.1
                                            • med-ORF21
                                            		 21350 - 22366 (+) putative carbohydrate kinase
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                                              • BAC79035.1
                                              • med-ORF13
                                              		 22425 - 22928 (-) NADH:FMN oxidoreductase
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                                                • BAC79036.1
                                                • med-ORF12
                                                		 22972 - 23946 (-) stereospecific keto reductase
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                                                  • BAC79037.1
                                                  • med-ORF11
                                                  		 24129 - 24905 (+) pathway-specific transcriptional activator (SARP)
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                                                    • BAC79038.1
                                                    • med-ORF10
                                                    		 24919 - 25359 (+) unknown (ActVI-A homologue)
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                                                      • BAC79039.1
                                                      • med-ORF9
                                                      		 25400 - 26419 (+) enoyl reductase
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                                                        • BAC79040.1
                                                        • med-ORF8
                                                        		 26416 - 27546 (+) C-glycosyl transferase
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                                                          • BAC79041.1
                                                          • med-ORF5
                                                          		 27628 - 28272 (-) pyran ring cyclase/possible exporter (ActVI-3 homologue)
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                                                            • BAC79042.1
                                                            • med-ORF6
                                                            		 28556 - 29341 (+) keto reductase (KR)
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                                                              • BAC79043.1
                                                              • med-ORF7
                                                              		 29375 - 30514 (+) oxygenase/hydroxylase
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                                                                • BAC79044.1
                                                                • med-ORF1
                                                                		 30657 - 31925 (+) ketosynthase (KS) alpha subunit
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                                                                  • BAC79045.1
                                                                  • med-ORF2
                                                                  		 31922 - 33148 (+) ketosynthase (KS) beta subunit
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                                                                    • BAC79046.1
                                                                    • med-ORF3
                                                                    		 33141 - 34049 (+) second ring cyclase (CYC)
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                                                                      • BAC79047.1
                                                                      • med-ORF4
                                                                      		 34145 - 35374 (-) putative secreted chitosanase
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                                                                        • BAC79048.1
                                                                        • ORF_Z
                                                                        		 35704 - >36201 (-) putative regulatory protein
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                                                                          Biosynthesis information
                                                                          Annotation changelog

                                                                          Entry version: 4

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2022-10-07
                                                                          Update chemical activity to schema version 2.11
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 3

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2022-09-15
                                                                          Updated bioactivity data
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 2

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2019-10-16
                                                                          Migrated from v1.4
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 1

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2015-06-12
                                                                          Submitted
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          Detailed domain annotation
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