BGC0000248: α naphtocyclinoic acid biosynthetic gene cluster from Streptomyces arenae DSM 40737
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Location: 94,867 - 120,787 nt. (total: 25,921 nt).
This entry is originally from NCBI GenBank JAKQYH010000014.1.

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core biosynthetic genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000248
Short description α naphtocyclinoic acid biosynthetic gene cluster from Streptomyces arenae DSM 40737
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
JAKQYH010000014.1
94867 - 120787
via Heterologous expression
Compounds
  • α naphtocyclinoic acid
  • fogacin
Species Streptomyces arenae DSM 40737 [taxonomy]
References
Chemical products information
α naphtocyclinoic acid Evidence:
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C32H28O15
fogacin Evidence:
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C16H16O6
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • MB828_08060
 95425 - 95547 (+) histidine kinase dimerization/phosphoacceptor domain-containing protein
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    • MB828_08065
    • MCG7203797.1
    		 95998 - 96606 (-) response regulator transcription factor
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      • MB828_08070
      • MCG7203798.1
      		 96957 - 97889 (+) MBL fold metallo-hydrolase
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        • MB828_08075
        • MCG7203799.1
        		 97859 - 98371 (-) flavin reductase family protein
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          • MB828_08080
          • MCG7203800.1
          		 98658 - 100190 (+) acyl-CoA carboxylase subunit beta
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            • MB828_08085
            • MCG7203801.1
            		 100370 - 101179 (+) AfsR/SARP family transcriptional regulator
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              • MB828_08090
              • MCG7203802.1
              		 101409 - 101837 (-) nuclear transport factor 2 family protein
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                • MB828_08095
                • MCG7203803.1
                		 102086 - 102871 (+) 3-oxoacyl-ACP reductase
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                  • MB828_08100
                  • MCG7203804.1
                  		 102871 - 103608 (+) SDR family oxidoreductase
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                    • MB828_08105
                    • MCG7203805.1
                    		 103668 - 104702 (+) LLM class flavin-dependent oxidoreductase
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                      • MB828_08110
                      • MCG7203806.1
                      		 104906 - 105709 (+) prenaphthocyclinone oxidase
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                        • MB828_08115
                        • MCG7203807.1
                        		 105816 - 107033 (-) flavin-dependent monooxygenase
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                          • MB828_08120
                          • MCG7203808.1
                          		 107033 - 107443 (-) DoxX family protein
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                            • MB828_08125
                            • MCG7203809.1
                            		 107663 - 108541 (+) naphthocyclinone dimerase
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                              • MB828_08130
                              • MCG7203810.1
                              		 108553 - 109758 (+) acyltransferase
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                                • MB828_08135
                                • MCG7203811.1
                                		 109883 - 111379 (-) DHA2 family efflux MFS transporter permease subunit
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                                  • MB828_08140
                                  • MCG7203812.1
                                  		 111490 - 112284 (+) TetR family transcriptional regulator
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                                    • MB828_08145
                                    • MCG7203813.1
                                    		 112281 - 112712 (+) PPOX class F420-dependent oxidoreductase
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                                      • MB828_08150
                                      • MCG7203814.1
                                      		 112758 - 113702 (-) TIGR03619 family F420-dependent LLM class oxidoreductase
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                                        • MB828_08155
                                        • MCG7203815.1
                                        		 113954 - 114817 (+) SAM-dependent methyltransferase
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                                          • MB828_08160
                                          • MCG7203816.1
                                          		 114821 - 115381 (+) hypothetical protein
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                                            • MB828_08165
                                            • MCG7203817.1
                                            		 115539 - 116486 (-) aromatase/cyclase
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                                              • MB828_08170
                                              • MCG7203818.1
                                              		 116483 - 116743 (-) acyl carrier protein
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                                                • MB828_08175
                                                • MCG7203819.1
                                                		 116788 - 118077 (-) ketosynthase chain-length factor
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                                                  • MB828_08180
                                                  • MCG7203820.1
                                                  		 118074 - 119339 (-) beta-ketoacyl-[acyl-carrier-protein] synthase family protein
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                                                    • MB828_08185
                                                    • MCG7203821.1
                                                    		 119451 - 120395 (-) M56 family metallopeptidase
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                                                      • MB828_08190
                                                      • MCG7203822.1
                                                      		 120404 - 120787 (-) BlaI/MecI/CopY family transcriptional regulator
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                                                        Biosynthesis information

                                                        Biosynthetic paths

                                                        naphthocyclinone
                                                        Pathway: ncnA/ncnB/ncnC > ncnQ > ncnD > ncnE > ncnP > ncnG > ncnH/ncnT > ncnN > ncnM > ncmO > ncnL > ncnJ > ncnI [2]
                                                        Annotation changelog

                                                        Entry version: next

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2024-03-19
                                                        MIBiG v4 annotathon
                                                        • (ID: HSOJFFPY5IUT4HBQLSN7DGJX)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 4

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2022-10-07
                                                        Update chemical activity to schema version 2.11
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 3

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2022-09-15
                                                        Updated bioactivity data
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 2

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2019-10-16
                                                        Migrated from v1.4
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 1

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2015-06-12
                                                        Submitted
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        Detailed domain annotation
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