BGC0000252: nonactin biosynthetic gene cluster from Streptomyces griseus subsp. griseus
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Location: 1 - 15,559 nt. (total: 15,559 nt).
This entry is originally from NCBI GenBank AF074603.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
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Biosynthesis
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000252
Short description nonactin biosynthetic gene cluster from Streptomyces griseus subsp. griseus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
AF074603.2
via
Compounds
  • nonactin
Species Streptomyces griseus subsp. griseus [taxonomy]
References
Chemical products information
nonactin Evidence:
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C40H64O12
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAD37450.1
  • nonK
 249 - 1526 (+) NonK
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    • AAD37451.1
    • nonJ
    		 1516 - 2796 (+) NonJ
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      • AAD37452.1
      • nonM
      		 2793 - 4394 (+) putative ketoacyl reductase
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        • AAD37453.1
        • nonE
        		 4391 - 5206 (+) putative ketoacyl reductase
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          • AAC26133.1
          • nonD
          		 5206 - 6915 (+) putative diester hydrolase
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            • AAC26134.1
            • nonL
            		 6912 - 8579 (+) putative nonactic acid:CoASH ligase
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              • AAC26135.1
              • nonS
              		 8576 - 9469 (+) nonactate synthase
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                • AAD37454.1
                • nonR
                		 9705 - 10544 (+) tetranactin resistance protein
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                  • AAD37455.1
                  • nonB
                  		 10560 - 11066 (+) NonB
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                    • AAD37456.1
                    • nonC
                    		 11255 - 12208 (+) NonC
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                      • AAD37457.1
                      • nonF
                      		 12384 - 13088 (+) NonF
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                        • AAD37458.1
                        • nonI
                        		 13237 - 13599 (+) putative acetoacetate reductase
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                          • AAD37459.1
                          • nonG
                          		 13623 - 14351 (-) putative transcriptional repressor
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                            • AAD37460.1
                            • nonH
                            		 14440 - 15270 (+) putative flavoprotein reductase
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                              Biosynthesis information
                              Annotation changelog

                              Entry version: 4

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-10-07
                              Update chemical activity to schema version 2.11
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 3

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-09-15
                              Updated bioactivity data
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 2

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2019-10-16
                              Migrated from v1.4
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 1

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2015-06-12
                              Submitted
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              Detailed domain annotation
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