BGC0000253: oviedomycin biosynthetic gene cluster from Streptomyces antibioticus
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Location: 1 - 24,720 nt. (total: 24,720 nt).
This entry is originally from NCBI GenBank AJ632203.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000253
Short description oviedomycin biosynthetic gene cluster from Streptomyces antibioticus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type II)
Loci
AJ632203.2
via Knock-out studies, Heterologous expression
Compounds
  • oviedomycin
Species Streptomyces antibioticus [taxonomy]
References
Chemical products information
oviedomycin Evidence:
Copy SMILES
C19H10O7
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAG14955.2
 2 - 1219 (+) tRNA-synthetase class I
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    • CAG14956.1
    		 1226 - 1861 (-) putative pyridoxine 5-phosphate oxidase
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      • CAG14957.1
      		 1862 - 2224 (-) ArsR regulator
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        • CAG14958.1
        • ovmE
        		 2389 - 3627 (+) putative transmembrane efflux protein from the major facilitator superfamily
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          • CAG14959.1
          • ovmX
          		 3855 - 4688 (+) putative nucleotide-diphosphate-sugar epimerase
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            • CAG14960.1
            • ovmY
            		 4685 - 5332 (+) TetR-family transcriptional repressor
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              • CAG14961.1
              • ovmZ
              		 5534 - 6259 (-) ovmZ protein
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                • CAG14962.1
                • ovmR
                		 6760 - 7527 (+) IclR-family regulator
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                  • CAG14963.1
                  • ovmOI
                  		 7963 - 9447 (+) oxygenase
                  • Tailoring
                  • Other in vivo study
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                  • CAG14964.1
                  • ovmC
                  		 9556 - 9888 (+) cyclase
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                    • CAG14965.1
                    • ovmP
                    		 9885 - 11009 (+) keto-acyl synthase alpha
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                      • CAG14966.1
                      • ovmK
                      		 11006 - 12229 (+) keto-acyl synthase beta
                      • Scaffold biosynthesis
                      • Knock-out
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                      • CAG14967.1
                      • ovmS
                      		 12310 - 12582 (+) acyl carrier protein
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                        • CAG14968.1
                        • ovmT
                        		 12706 - 13488 (+) ketoreductase
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                          • CAG14969.1
                          • ovmA
                          		 13516 - 14463 (+) aromatase
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                            • CAG14970.1
                            • ovmOII
                            		 14453 - 15925 (+) oxygenase
                            • Tailoring
                            • Other in vivo study
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                            • CAG14971.1
                            • ovmOIII
                            		 15945 - 17465 (+) oxygenase
                            • Tailoring
                            • Other in vivo study
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                            • CAG14972.1
                            • ovmF
                            		 17521 - 18402 (+) 4'-phosphopantetheinyl transferase
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                              • CAG14973.1
                              • ovmG
                              		 18386 - 19930 (+) acetyl-CoA carboxylase complex, beta-chain
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                                • CAG14974.1
                                • ovmH
                                		 20498 - 22216 (+) acetyl-CoA carboxylase complex, alpha-chain
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                                  • CAG14975.1
                                  		 22247 - 22765 (-) putative MarR-family repressor
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                                    • CAG14976.1
                                    		 22849 - 23652 (+) putative 3-keto-acyl carrier protein reductase
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                                      • CAG14977.1
                                      		 23903 - 24418 (+) hypothetical protein
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                                        • CAG14978.1
                                        		 24415 - >24720 (+) hypothetical protein
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                                          Biosynthesis information
                                          Annotation changelog

                                          Entry version: 3

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2022-10-07
                                          Update chemical activity to schema version 2.11
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 2

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2019-10-16
                                          Migrated from v1.4
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          2019-10-16
                                          Updated compound(s) information (NPAtlas curation)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 1

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2015-06-12
                                          Submitted
                                          • (ID: QGSJT55NWIBPAZQIATLZ7G55)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          Detailed domain annotation
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