BGC0000256 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000256 (Actinomadura hibisca)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	37,100	High	pradimicin-A	PKS

BGC0000256 - Region 1 - T2PKS

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Location: 1 - 37,100 nt. (total: 37,100 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 37,101
Label		BGC0000256

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

pdmG: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

pdmJ: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

pdmV: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

pdmW: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: aminotransferase carboxylase glycosyltransferase methyltransferase transferase

pdmF: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

pdmO: methyltransferase

smcogs: SMCOG1248: methyltransferase

pdmP1: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

pdmQ: glycosyltransferase

smcogs: SMCOG1102: glycosyltransferase

pdmS: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

pdmT: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

pdmU: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

pdmX: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

Hydrolases: hydrolase

pdmN: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: cyclase dehydratase

pdmD: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

pdmK: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

pdmY: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

pdmA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

pdmB: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000256.3	1.00	PKS	pradimicin-A	Actinomadura hibisca
BGC0000231.5	0.71	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000272.3	0.62	PKS	spore pigment	Streptomyces collinus
BGC0001197.5	0.61	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001723.5	0.61	PKS	oviedomycin	Streptomyces antibioticus
BGC0000275.4	0.60	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0000234.5	0.58	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000215.5	0.57	PKS	curamycin	Streptomyces cyaneus
BGC0001513.3	0.57	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0000898.5	0.57	saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000256.3	1.00	PKS	pradimicin-A	Actinomadura hibisca
BGC0000231.5	0.71	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000272.3	0.62	PKS	spore pigment	Streptomyces collinus
BGC0001197.5	0.61	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001723.5	0.61	PKS	oviedomycin	Streptomyces antibioticus
BGC0000275.4	0.60	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0000234.5	0.58	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000215.5	0.57	PKS	curamycin	Streptomyces cyaneus
BGC0001513.3	0.57	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0000898.5	0.57	saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 37100
Starter unit(s):: malonamyl-CoA (Score: 625.0; E-value: 0)
Malonyl elongations:: 11|12 (Score: 679.7; E-value: 2.6e-207)
Product class(es):: pentangular polyphenol
Product molecular weight(s):: malonamyl-CoA_11: 876 Da
malonamyl-CoA_12: 918 Da

pdmA: KS (Score: 775.5; E-value: 2.7e-236)
pdmB: CLF 11|12 (Score: 679.7; E-value: 2.6e-207)
pdmC: ACP (Score: 102.7; E-value: 2e-32)
pdmD: CYC C9-C14 (Score: 246.2; E-value: 2.3e-76)
pdmF: MET C11O (Score: 527.4; E-value: 3e-161)
pdmG: KR C19 (Score: 387.1; E-value: 7.8e-119)
pdmK: CYC C4-C21/C2-C23|C2-C19 (Score: 136.6; E-value: 6.8e-43)
pdmL: CYC C5-C18 (Score: 219.9; E-value: 2e-68)
pdmN: AMID (Score: 844.6; E-value: 8.7e-257); AMID ADE34521.1_SF2575_malonamyl-CoA (Score: 625.0; E-value: 0.0)
pdmQ: GT (Score: 239.5; E-value: 1.9e-73)
pdmS: GT (Score: 299.2; E-value: 1.4e-91)
pdmT: MET C13O|C17O (Score: 503.5; E-value: 5.2e-154)