Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000261.1:
Cluster 1Polyketide117200

BGC0000261, R1128 biosynthetic gene cluster from Streptomyces sp. R1128. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: R1128

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide synthase subclass:
Type II

Gene cluster description

R1128 (BGC0000261). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank AF293442. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

Literature references

1. Marti T et al. (2000) Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming mechanism. J Biol Chem 275(43):33443-8. doi: 10.1074/jbc.M006766200.