BGC0000263 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000263 (Streptomyces ravidus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	32,801	High	ravidomycin	PKS

BGC0000263 - Region 1 - T2PKS

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Location: 1 - 32,801 nt. (total: 32,801 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 32,802
Label		BGC0000263

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxygenase

ravF: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

ravOI: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

ravOIII: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

ravOIV: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

ravRM: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

Transferases: acylase aminotransferase glycosyltransferase methyltransferase transferase

ravAMT: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

ravD: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

ravGT: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

ravMT: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

ravNMT: methyltransferase

smcogs: SMCOG1248: methyltransferase

ravP: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

ravQ: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Lyases: cyclase dehydratase

ravE: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

ravG: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

ravK: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

ravA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ravB: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000263.5	1.00	PKS	ravidomycin	Streptomyces ravidus
BGC0000231.5	0.65	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002154.2	0.62	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.62	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001723.5	0.61	PKS	oviedomycin	Streptomyces antibioticus
BGC0000272.3	0.59	PKS	spore pigment	Streptomyces collinus
BGC0002084.4	0.57	ribosomal	biarylitide YYH	Planomonospora sp. ID82291

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000263.5	1.00	PKS	ravidomycin	Streptomyces ravidus
BGC0000231.5	0.65	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002154.2	0.62	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.62	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001723.5	0.61	PKS	oviedomycin	Streptomyces antibioticus
BGC0000272.3	0.59	PKS	spore pigment	Streptomyces collinus
BGC0002084.4	0.57	ribosomal	biarylitide YYH	Planomonospora sp. ID82291

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

ravQ: mal

PKS_AT (9..302): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 57.2
Methylmalonyl-CoA: 28.9
Methoxymalonyl-CoA: 28.3
Ethylmalonyl-CoA: 19.6
fatty_acid: 15.0
Propionyl-CoA: 14.9
CHC-CoA: 12.5
trans-1,2-CPDA: 12.4
2-Methylbutyryl-CoA: 11.2
inactive: 10.7
Benzoyl-CoA: 9.6
Acetyl-CoA: 9.5
Isobutyryl-CoA: 8.8
3-Methylbutyryl-CoA: 0.0

ravP: mal

PKS_AT (6..297): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 70.2
Methylmalonyl-CoA: 38.5
Methoxymalonyl-CoA: 32.7
Propionyl-CoA: 22.1
inactive: 19.5
2-Methylbutyryl-CoA: 17.2
Isobutyryl-CoA: 13.7
CHC-CoA: 13.0
Ethylmalonyl-CoA: 12.9
Benzoyl-CoA: 11.4
trans-1,2-CPDA: 10.6
fatty_acid: 10.6
Acetyl-CoA: 9.3
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 0 to 32801
Starter unit(s):: propionyl-CoA (Score: 633.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 703.9; E-value: 1.2e-214)
Product class(es):: angucycline
Product molecular weight(s):: propionyl-CoA_8: 574 Da
propionyl-CoA_9: 616 Da

ravA: KS (Score: 782.8; E-value: 1.6e-238)
ravB: CLF 8|9 (Score: 703.9; E-value: 1.2e-214)
ravC: ACP (Score: 114.4; E-value: 4.2e-36)
ravC1: ACP (Score: 113.2; E-value: 1e-35)
ravF: KR C9 (Score: 470.5; E-value: 3e-144)
ravG: CYC C4-C17/C2-C19 (Score: 189.1; E-value: 1.8e-58)
ravGT: GT (Score: 381.4; E-value: 1.5e-116)
ravK: CYC C7-C12 (Score: 462.7; E-value: 1e-141)
ravMT: MET (Score: 314.3; E-value: 2.3e-96)
ravOI: OXY (Score: 563.6; E-value: 8.7e-172)
ravOIV: OXY (Score: 488.2; E-value: 6.3e-149)
ravQ: AT (Score: 384.2; E-value: 1.2e-117); AT CBH32803.1_Ravidomycin_propionyl-CoA (Score: 633.0; E-value: 0.0)