BGC0000273: steffimycin D biosynthetic gene cluster from Streptomyces steffisburgensis
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Location: 1 - 42,877 nt. (total: 42,877 nt).
This entry is originally from NCBI GenBank AM156932.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000273
Short description steffimycin D biosynthetic gene cluster from Streptomyces steffisburgensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type II)
  • saccharide (hybrid/tailoring)
Loci
AM156932.1
via Knock-out studies, Heterologous expression
Compounds
  • steffimycin D
Species Streptomyces steffisburgensis [taxonomy]
References
Chemical products information
steffimycin D Evidence:
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C28H32O12
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAJ42313.1
 51 - 1502 (-) putative inosine monophosphate dehydrogenase
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    • CAJ42314.1
    		 1602 - 1955 (-) hypothetical protein
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      • CAJ42315.1
      		 1980 - 3023 (-) putative transcriptional regulator
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        • CAJ42316.1
        		 3102 - 3788 (-) putative ribulose-phosphate 3-epimerase
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          • CAJ42317.1
          • sfrA
          		 3953 - 6091 (+) putative membrane protein
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            • CAJ42318.1
            • stfS
            		 6118 - 6378 (-) acyl carrier protein
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              • CAJ42319.1
              • stfK
              		 6391 - 7611 (-) chain length factor
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                • CAJ42320.1
                • stfP
                		 7620 - 8888 (-) ketoacyl synthase
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                  • CAJ42321.1
                  • stfOI
                  		 8890 - 9225 (-) monooxygenase
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                    • CAJ42322.1
                    • stfT
                    		 9351 - 10175 (-) ketoreductase
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                      • CAJ42323.1
                      • stfX
                      		 10200 - 10640 (-) cyclase
                      • Scaffold biosynthesis
                      • Knock-out
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                      • CAJ42324.1
                      • stfY
                      		 10818 - 11597 (+) cyclase
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                        • CAJ42325.1
                        • stfRI
                        		 11796 - 12668 (+) SARP family regulator
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                          • CAJ42326.1
                          • stfRII
                          		 12711 - 13301 (-) transcriptional regulator
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                            • CAJ42327.1
                            • stfQ
                            		 13694 - 14623 (+) aromatase
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                              • CAJ42328.1
                              • stfMI
                              		 14616 - 15293 (+) O-methyl transferase
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                                • CAJ42329.1
                                • stfC
                                		 15424 - 15987 (-) SWIM Zn-finger
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                                  • CAJ42330.1
                                  • stfD
                                  		 15984 - 17840 (-) SNF2 related domain
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                                    • CAJ42331.1
                                    • sfrB
                                    		 17833 - 19341 (-) putative transmembrane efflux protein
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                                      • CAJ42332.1
                                      • stfRIII
                                      		 19419 - 19919 (+) putative transcriptional regulator
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                                        • CAJ42333.1
                                        • stfPI
                                        		 19995 - 21203 (+) cytochrome P450
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                                          • CAJ42334.1
                                          • stfE
                                          		 21249 - 22829 (+) dehydrogenase
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                                            • CAJ42335.1
                                            • stfOII
                                            		 22887 - 24050 (-) putative oxygenase
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                                              • CAJ42336.1
                                              • stfMII
                                              		 24068 - 25243 (-) O-methyl transferase
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                                                • CAJ42337.1
                                                • stfF
                                                		 25233 - 25574 (-) putative 5-chloromuconolactone dehalogenase
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                                                  • CAJ42338.1
                                                  • stfG
                                                  		 25654 - 26916 (-) glycosyltransferase
                                                  • Tailoring
                                                  • Knock-out
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                                                  • CAJ42339.1
                                                  • stfPII
                                                  		 26977 - 28077 (-) cytochrome P450-like
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                                                    • CAJ42340.1
                                                    • stfMIII
                                                    		 28239 - 29417 (+) O-methyl transferase
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                                                      • CAJ42341.1
                                                      		 29583 - 33797 (-) hypothetical protein
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                                                        • CAJ42342.1
                                                        		 33847 - 34971 (-) hypothetical protein
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                                                          • CAJ42343.1
                                                          		 34976 - 36010 (-) putative trypsin-like serine protease
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                                                            • CAJ42344.1
                                                            		 36061 - 37308 (-) hypothetical protein
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                                                              • CAJ42345.1
                                                              		 37796 - 39223 (-) hypothetical Sun-family protein
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                                                                • CAJ42346.1
                                                                		 39673 - 40605 (-) putative methionyl-tRNA formyltransferase
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                                                                  • CAJ42347.1
                                                                  		 40935 - 41486 (+) hypothetical protein
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                                                                    • CAJ42348.1
                                                                    		 41608 - >42876 (-) putative primosomal protein N'
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                                                                      Biosynthesis information
                                                                      Annotation changelog

                                                                      Entry version: 4

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2022-10-07
                                                                      Update chemical activity to schema version 2.11
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                      Entry version: 3

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2022-09-15
                                                                      Updated bioactivity data
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                      Entry version: 2

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2019-10-16
                                                                      Migrated from v1.4
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      2019-10-16
                                                                      Updated compound(s) information (NPAtlas curation)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                      Entry version: 1

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2015-06-12
                                                                      Submitted
                                                                      • (ID: IROSGRAECON7XFWB774QFHDN)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      Detailed domain annotation
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