BGC0000274 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000274 (uncultured bacterium)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS,phenazine	1	34,510	High	tetarimycin A/tetarimycin B	PKS:Type II

BGC0000274 - Region 1 - T2PKS,phenazine

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Location: 1 - 34,510 nt. (total: 34,510 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)
phenazine: phzB

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 34,511
Label		BGC0000274

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

AFY23017.1: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

AFY23020.1: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

AFY23033.1: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

AFY23034.1: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

AFY23037.1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

AFY23045.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: methyltransferase

AFY23021.1: methyltransferase

smcogs: SMCOG1248: methyltransferase

AFY23025.1: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

AFY23046.1: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Hydrolases: hydrolase

AFY23028.1: isochorismatase

smcogs: SMCOG1027: isochorismatase

Lyases: cyclase dehydratase

AFY23016.1: L-carnitine dehydratase/bile acid-inducible

smcogs: SMCOG1189: L-carnitine dehydratase/bile acid-inducible

AFY23038.1: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

AFY23043.1: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

AFY23044.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000274.5	1.56	PKS	tetarimycin A, tetarimycin B	uncultured bacterium
BGC0000936.5	0.40	other (other)	pyocyanine	Pseudomonas aeruginosa PAO1
BGC0001302.5	0.40	other (other)	lomofungin	Streptomyces lomondensis
BGC0000272.3	0.39	PKS	spore pigment	Streptomyces collinus
BGC0002561.3	0.38	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0001221.5	0.34	other (phenazine)	marinophenazine A, phenaziterpene A	Streptomyces sp. CNQ-509
BGC0000275.4	0.34	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0001868.4	0.33	other (phenazine)	iodinin	Xenorhabdus szentirmaii DSM 16338
BGC0001723.5	0.33	PKS	oviedomycin	Streptomyces antibioticus
BGC0001869.4	0.32	NRPS, other (phenazine)	griseoluteic acid, demethoxygriseoluteic acid, phenaszentine A, phenaszentine C, phenaszenketide C, phenaszenketide D	Xenorhabdus szentirmaii DSM 16338

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000274.5	1.00	PKS	tetarimycin A, tetarimycin B	uncultured bacterium
BGC0000231.5	0.63	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000272.3	0.62	PKS	spore pigment	Streptomyces collinus
BGC0000234.5	0.60	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000275.4	0.56	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0002000.4	0.56	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0001513.3	0.56	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0001197.5	0.55	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001723.5	0.55	PKS	oviedomycin	Streptomyces antibioticus
BGC0000936.5	0.54	other (other)	pyocyanine	Pseudomonas aeruginosa PAO1

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 34510
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 691.3; E-value: 8e-211)
Product molecular weight(s):: acetyl-CoA_8: 397 Da
acetyl-CoA_9: 439 Da

AFY23025.1: MET (Score: 220.3; E-value: 8.6e-68)
AFY23033.1: OXY (Score: 19.2; E-value: 1.2e-06)
AFY23034.1: KR (Score: 153.4; E-value: 2.1e-47)
AFY23037.1: OXY (Score: 253.9; E-value: 7.9e-78)
AFY23038.1: CYC C9-C14 (Score: 133.4; E-value: 1.2e-41)
AFY23039.1: CYC C5-C14/C3-C16 (Score: 305.6; E-value: 6.6e-94)
AFY23042.1: ACP (Score: 88.4; E-value: 5.7e-28)
AFY23043.1: CLF 8|9 (Score: 691.3; E-value: 8e-211)
AFY23044.1: KS (Score: 789.6; E-value: 1.4e-240)
AFY23045.1: KR (Score: 169.6; E-value: 2.4e-52)
AFY23046.1: MET C6|C8 (Score: 520.9; E-value: 2.7e-159)